Berman Lab
Selected Publications
1. Andersson S, Berman DM, Jenkins EP, Russell DW. Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism (1991). Nature 1991;354:159-161. PubMed
2. Berman DM, Russell DW (1993). Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes. Proc Natl Acad Sci USA; 90:9359-9363. PubMed
3. Berman DM, Tian H, Russell DW (1995). Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat. Mol. Endocrinol; 9:1561-1570. PubMed
4. Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. (2002) Medulloblastoma growth inhibition by Hedgehog pathway blockade. Science; 297:1559-1561. PubMed
5. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, and Baylin SB. (2003) Hedgehog signalling within airway epithelial progenitors and in small cell lung cancer. Nature; 422:313-317. PubMed
6. Watkins DN, Berman DM, Baylin SB (2003). Hedgehog signaling: progenitor phenotype in small-cell lung cancer. Cell Cycle; 2:196-198. PubMed
7. Berman DM, Karhadkar SS, Maitra AM, Montes de Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, and Beachy PA. (2003)Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425:846-851. PubMed
8. Berman DM, Desai N, Wang X, Karhadkar SS, Reynon M, Abate-Shen C, Beachy PA, and Shen MM. Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. (2004) Developmental Biology 7:387-398. PubMed
9. Beachy PA, Karhadkar SS, and Berman DM. Mending and Malignancy. (2004) Nature. 431:402. PubMed
10. Karhadkar SS, Bova GB, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, and Beachy PA. (2004) Hedgehog Signaling in prostate regeneration, neoplasia and metastasis. Nature. 431:707-712. PubMed
11. Beachy PA, Karhadkar SS. & Berman DM. (2004) Tissue repair and stem cell renewal in carcinogenesis. Nature 432:324-331. PubMed
12. Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. (2007) A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nature Genetics; 39:237-42. PubMed
13. Duelli DM, Padilla-Nash HM, Berman D, Murphy KM, Ried TM, Lazebnik Y. A (2007) virus causes cancer by inducing massive chromosomal instability through cell fusion. Current Biology; 17:431-7. PubMed
14. Kleeberger W, Bova GS, Nielsen ME, Herawi M, Chuang AY, Epstein JI, Berman DM (2007). Roles for the stem cell associated intermediate filament nestin in prostate cancer migration and metastasis. Cancer Research; 67:9199-206. PubMed
15. Schaeffer EM, Marchionni L, Huang Z, Simons B, Blackman A, Yu W, Parmigiani G, Berman DM.(2008). Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. Oncogene; 27:7180-91. PubMed
16. Xiaobing He, Luigi Marchionni, Donna E. Hansel, Wayne Yu, Akshay Sood, Jie Yang, Giovanni Parmigiani, William Matsui, David M. Berman (2009). Differentiation of a Highly Tumorigenic Basal Cell Compartment in Urothelial Carcinoma. Stem Cells; 27:1487-95. PubMed