Dorothy L. Rosenthal, M.D.
Professor of Pathology, Oncology and Gynecology and Obstetrics.
Director of Cytopathology, The Sidney Kimmel Comprehensive Cancer
Center At Johns Hopkins University
M.D., University of Kansas Medical Center, Lawrence, KS
Post-Sophomore Fellow in Pathology, University of Kansas, Lawrence,
Intern in Pathology, University of Illinois, IL
Resident in Pathology, Milwaukee County General, Milwaukee, WI
National Board of Medical Examiners, Kansas, Wisconsin, California,
New York, Maryland American Board of Pathology Anatomic and Clinical
Pathology, American Board of Pathology added qulification in
Cervical Cancer Screening, Breast Cancer, Thyroid Tumors
clinically-oriented cytopathologist, my research efforts are
directed at answering diagnostic questions which are difficult or
impossible when relying solely on morphologic features. Cervico-vaginal
specimens (Pap smears) are perhaps the most challenging samples
facing the cytologist. I have devoted much of my career to seeking
ways to augment light microscopic diagnoses via computers. Neural
networks combined with traditional image processing techniques have
shown promise for automated scanning of slides. The ability of such
systems to detect rare abnormal cells for human verification is
being validated, still, but they promise to reduce the error rate of
Pap Test interpretation. Our cytologists continue to be involved in
the development of these devices. Determination of molecular
changes, currently telomerase activity in neoplasms of the thyroid
and breast, utilizing routinely acquired cell samples is the next
challenge for me in collaboration with my clinical and research
Automation and the Endangered Future of the Pap Test (invited
Commentary), JNCI 90:738-749, 1998.
LSIL. Rosenthal DL, member of Pathology QC Group. Interobserver
Reproducibility of Cervical Cytologic and Histologic
Interpretations. Realistic Estimates from the ASCUS-LSIL Triage
Study. JAMA 285(11):1500-1505, 2001.
E, Dooley WC, Umbricht CB, Rosenthal DL, Sacchi N, Gabrielson E,
Soito AB, Hung DT, Ljung BM, Davidson NE, Sukumar S. Detection of
Breast Cancer Cells in Ductal Lavage Fluid by Methylation Specific
PCR. Lancet 357:1335-1336, 2001.
LSIL. Rosenthal DL, member of Pathology QC Group. Comparison of
Three Management Strategies for Patients with Atypical Squamous
Cells of Undetermined Significance: Baseline Results from a
Randomized Trial. JNCI 93(4):293-299, 2001.