Dorothy L. Rosenthal, M.D.

Co-Investigator,Project 1

Professor of Pathology, Oncology and Gynecology and Obstetrics.

Director of Cytopathology, The Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins University 




M.D., University of Kansas Medical Center, Lawrence, KS



Postgraduate Training:

Post-Sophomore Fellow in Pathology, University of Kansas, Lawrence, KS
Intern in Pathology, University of Illinois, IL
Resident in Pathology, Milwaukee County General, Milwaukee, WI



Board Certifications:

National Board of Medical Examiners, Kansas, Wisconsin, California, New York, Maryland American Board of Pathology Anatomic and Clinical Pathology, American Board of Pathology added qulification in Cytopathology

Appointments: (410) 955-3520

Clinical Interests:

Cervical Cancer Screening, Breast Cancer, Thyroid Tumors


As a clinically-oriented cytopathologist, my research efforts are directed at answering diagnostic questions which are difficult or impossible when relying solely on morphologic features. Cervico-vaginal specimens (Pap smears) are perhaps the most challenging samples facing the cytologist. I have devoted much of my career to seeking ways to augment light microscopic diagnoses via computers. Neural networks combined with traditional image processing techniques have shown promise for automated scanning of slides. The ability of such systems to detect rare abnormal cells for human verification is being validated, still, but they promise to reduce the error rate of Pap Test interpretation. Our cytologists continue to be involved in the development of these devices. Determination of molecular changes, currently telomerase activity in neoplasms of the thyroid and breast, utilizing routinely acquired cell samples is the next challenge for me in collaboration with my clinical and research colleagues.


Selected Publications

Rosenthal DL: Automation and the Endangered Future of the Pap Test (invited Commentary), JNCI 90:738-749, 1998.

ALTS-Triage of LSIL. Rosenthal DL, member of Pathology QC Group. Interobserver Reproducibility of Cervical Cytologic and Histologic Interpretations. Realistic Estimates from the ASCUS-LSIL Triage Study. JAMA 285(11):1500-1505, 2001.

Evron E, Dooley WC, Umbricht CB, Rosenthal DL, Sacchi N, Gabrielson E, Soito AB, Hung DT, Ljung BM, Davidson NE, Sukumar S. Detection of Breast Cancer Cells in Ductal Lavage Fluid by Methylation Specific PCR. Lancet 357:1335-1336, 2001.

ALTS-Triage of LSIL. Rosenthal DL, member of Pathology QC Group. Comparison of Three Management Strategies for Patients with Atypical Squamous Cells of Undetermined Significance: Baseline Results from a Randomized Trial. JNCI 93(4):293-299, 2001.





Project 1




Keerti Shah

Patti Gravitt

Dorothy Rosenthal

Sudha Sivaram

Richard Daniel

Kathleen Cho




Joy Mays







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