Keerti Shah, M.D., Dr. PH.
Johns Hopkins University
School of Medicine
MBBS, Univ. of Poona,
India, 1951; MPH, Johns Hopkins School of Public Health, 1957; DrPH,
Johns Hopkins School of Public Health, 1963
615 North Wolfe Street,
Baltimore, MD 21205
Our virus laboratory
investigates human diseases associated with papillomaviruses and
polyomaviruses, in close collaboration with Dr. Maura Gillison
(Oncology) and Dr Patti Gravitt (Epidemiology)
Human papillomaviruses (HPVs)
are small DNA viruses that naturally fall into cutaneous and mucosal
types. About 40 mucosal HPVs inhabit the genital tract. We
participated in research that established that infection with any
one of a subset of these HPVs is the primary and necessary event
that eventually leads to invasive cervical cancer. There are about
500,000 cases of cervical cancer, annually, worldwide.
Our current research in
HPVs is centered around the following topics. The genital tract HPVs
that cause cervical cancer also seem to be etiologically linked to
about one half of cancers of the oropharynx. We are examining the
virologic and clinical characteristics of these cancers and also how
alcohol and tobacco use may interact with HPV infections in the
development of these cancers. We are planning to test if patients
with these cancers will benefit from HPV-based therapeutic vaccines
that are being developed for the treatment of cervical cancer. In a
second area, we have projects in collaboration with investigators in
India which are aimed at comparing HPV-based and other screening
strategies (including Pap smears) for detection of pre-invasive
cervical disease and in identifying cellular and viral biomarkers
which might be predictive of progression to high grade pre-invasive
or to invasive cervical cancer. We are also studying an HPV-caused
disease in children, juvenile-onset recurrent respiratory
papillomatosis (JORRP), in which benign papillomas, most often
located on the vocal cords, may result in life-threatening
respiratory obstruction. The HPV types that cause JORRP are
transmitted from an infected mother to the child at the time of
birth. We are investigating if cesarean delivery would prevent JORRP
and if the risk of transmission varies with the infecting virus
We are investigating the
pathogenic potential of human polyomaviruses BKV and JCV, and the
rhesus polyomavirus SV40.Some recent reports imply that SV40, which
was an inadvertent contaminant of polio vaccines administered in the
late 1950's is now established as a human infection, and that it
contributes to the development of a number of human cancers. We are
investigating this possibility by studying cancer patients and
controls for virological and serological markers of SV40 infection,
and by examination of cancer tissues for SV40 sequences. Our results
to date do not indicate that SV40 is a human carcinogen.
and Immunology, human papillomaviruses, cervical cancer,
Castellsague X, Bosch
FX, Munoz N, Meijer CJLM, Shah KV, de Sanjose S, Eluf-Neto J,
Ngelangel C, Chichareon S, Smith J, Herrero R, Franceschi S for the
IARC Multicentric Cervical Cancer Study Group: Male circumcision,
penile human papillomavirus infection and cervical cancer. N Engl J
Med 346:1105-12, 2002.
Bosch FX, Lorincz A,
Munoz N, Meijer CJ, Shah KV. The causal relation between human
papillomavirus and cervical cancer. J Clin Pathol 55:244-265, 2002.
Engels AE, Sarkar C,
Daniel RW, Gravitt PE, Verma K, Quezado M, Shah KV: Absence of Simian Virus 40 in
human brain tumors from Northern India. Int J Cancer 101: 348-352, 2002.
The International SV40
Working Group (KV Shah, member): A multicenter evaluation of assays
for detection of SV40 DNA and results in masked mesothelioma
specimens. Cancer Epidemiol Biomarkers Prev 10: 523-532, 2001.
Shah KV: Does SV40
infection contribute to the development of human cancers? Rev Med Virol 10: 31-43,
Gillison ML, Koch WM,
Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M,
Symer DE, Shah KV, Sidransky D: Evidence for a causal association between
human papillomavirus and a subset of head and neck cancers.
JNCI 92: 709-720, 2000.
Walboomers JMM, Jacobs
MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJF, Peto J,
Meijer CJLM and Muñoz N: Human papillomavirus is a necessary cause
of invasive cervical cancer worldwide. J Pathol 189:12-19, 1999.