Patti Gravitt, Ph.D.

Co-Investigator of Project 1 and

Career Development Program

Assistant Professor,

Bloomberg School of Public Health,

Johns Hopkins University


Academic Degrees
M.S. UNC-Charlotte, 1991;

Ph.D. Johns Hopkins University (BSPH), 2002

Departmental Affiliation
Epidemiology

Joint Departmental Affiliations
Molecular Microbiology and Immunology

Departmental Address
615 N. Wolfe St., Room E6014
Baltimore, MD 21205

Email:
pgravitt@jhsph.edu
Phone: 443-287-6179
Fax: 410-955-1393


Research


Dr. Gravitt's research interests are primarily focused on the molecular epidemiology and detection/screening for human papillomaviruses and cervical cancer. She has developed and validated gold standard PCR-based methods for the detection and quantitation of human papillomaviruses. Recent work has been dedicated to understanding the role of HPV viral load in the progression of cervical neoplasia and understanding other biologic and environmental factors that influence detectable viral load in women without evidence of cervical disease.

Dr. Gravitt's current research agenda includes evaluation of cervical cancer screening strategies in rural India, evaluation of inflammatory biomarkers in STI clinic populations, and methodologic issues of misclassification of laboratory derived exposure measures.


Keywords


Epidemiology,human papillomavirus; cervical cancer; molecular epidemiology; misclassification; viral etiology of cancer; pcr

Selected Publications


1.
Kreimer AR, Alberg AJ, Daniel R, Gravitt PE, Viscidi R, Garrett ES, Shah KV, Gillison ML. Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J Infect Dis 2003;189:686-98.

2. Burk RD, Terai M, Gravitt PE, Brinton LA, Kurman RJ, Barnes WA, Greenberg MD, Hadjimichael OC, Fu L, McGowan L, Mortel R, Schwartz PE, Hildesheim A. Distribution of human papillomavirus types 16 and 18 variants in squamous cell carcinomas and adenocarcinomas of the cervix. Cancer Res 2003;63:7215-20.

3. Sherman ME, Wang SS, Wheeler CM, Rich L, Gravitt PE, Tarone R, Schiffman M. Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions. Cancer Epidemiol Biomarkers Prev. 2003;12:1038-44.

4. Gravitt PE, Peyton C, Wheeler C, Apple R, Higuchi R, Shah KV. Reproducibility of HPV 16 and HPV 18 viral load quantitation using TaqMan real-time PCR assays. J Virol Methods 2003;112:23-33.

5. Lacey JV Jr, Swanson CA, Brinton LA, Altekruse SF, Barnes WA, Gravitt PE, Greenberg MD, Hadjimichael OC, McGowan L, Mortel R, Schwartz PE, Kurman RJ, Hildesheim A. Obesity as a potential risk factor for adenocarcinoma and squamous cell carcinomas of the cervix. Cancer 2003;98:814-21.

6. Gravitt P, Hildesheim A, Lorincz AT, Burk RD, Sherman ME, Herrero R, Bratti MC, Rodriguez AC, Schiffman M. A comparison between real-time PCR and Hybrid Capture 2 for HPV DNA quantitation. Cancer Epidemiol Biomarkers Prev. 2003;12:477-84.

7. Gravitt PE, Hildesheim A, Herrero R, Schiffman M, Sherman ME, Bratti C, Rodriguez AC, Morera LA, Cardenas F, Bowman FP, Shah KV, Crowley-Nowick PA. Correlates of IL-10 and IL-12 concentrations in cervical secretions and association with HPV infection status. J Clin Immunol 2003;23:175-83.

8. Altekruse SF, Lacey JV Jr, Brinton LA, Gravitt PE, Silverberg SG, Barnes WA Jr, Greenberg MD, Hadjimichael OC, McGowan L, Mortel R, Schwartz PE, Hildesheim A. Comparison of HPV genotypes, sexual, and reproductive risk factors of cervical adenocarcinoma and squamous cell carcinoma: northeastern United States. Am J Obstet Gynecol 2003; 188:657-63.

9. Tran-Thanh D, Provencher D, Koushik A, Duarte-Franco E, Kessous A, Drouin P, Wheeler CM, Dubuc-Lissoir J, Gauthier P, Allaire G, Vauclair R, Dipaolo JA, Gravitt P, Franco E, Coutlee F. Herpes simplex virus type II is not a cofactor to human papillomavirus in cancer of the uterine cervix. Am J Obstet Gynecol. 2003; 188:129-34.

10. Gravitt PE, Peyton CL, Wheeler CM, Apple RJ, Higuchi R, Shah KV. Reproducibility of HPV 16 and HPV 18 viral load quantitation using Taqman real-time PCR assays with normalization to single-copy human gene. J Virol Methods 2003;112:23-33.

11. Engels EA, Sarkar C, Daniel RW, Gravitt PE, Verma K, Quezado M, Shah KV. Absence of simian virus 40 in human brain tumors from northern India. Int J Cancer. 2002; 101(4):348-52.

12. Lorincz AT, Castle PE, Sherman ME, Scott DR, Glass AG, Wacholder S, Rush BB, Gravitt PE, Schussler JE, Schiffman M. High viral load of a group of thirteen carcinogenic human papillomavirus types does not predict future risk of CIN3 or cervical cancer. Lancet 2002;360(9328):228-9.

13. Gravitt PE, Kamath AM, Gaffikin L, Womack S, Chirenje ZM, Shah KV. HPV genotype prevalence in HSIL and colposcopically normal women in Zimbabwe. Int J Cancer 2002;100(6):729-32.

14. Castle PE, Schiffman M, Gravitt PE, Kendall H, Fishman S, Hildesheim A, Herrero R, Bratti MC, Sherman ME, Lorincz A, Schussler JE, Burk RD. Comparisons of HPV DNA detection by MY09/11 PCR methods. J Med Virol 2002; 68:417-423.

15. Coutlee F, Gravitt P, Kornegay J, Hankins C, Richardson H, Lapointe N, Voyer H, The Canadian Women’s HIV Study Group, Franco E. Use of PGMY primers in L1 consensus PCR improves detection of human papillomavirus DNA in genital samples. J Clin Microbiol 2002;40:902-7.

16. Peyton CL, Gravitt PE, Hunt WC, Hundley RS, Zhao M, Apple RJ, Wheeler CM. Determinants of genital human papillomavirus detection in a US population. J Infect Dis 2001;183:1554-64.

17. Gravitt PE, Castle PE. Chlamydia trachomatis and cervical squamous cell carcinoma (letter). JAMA 2001;285:1703-4.

18. Lacey JV Jr, Frisch M, Brinton LA, Abbas FM, Barnes WA, Gravitt PE, Greenberg MD, Greene SM, Hadjimichael OC, McGowan L, Mortel R, Schwartz PE, Zaino RJ, Hildesheim A. Associations between smoking and adenocarcinomas and squamous cell carcinomas of the uterine cervix (United States). Cancer Causes Control 2001;12:153-61.

19. Liaw KL, Hildesheim A, Burk RD, Gravitt P, Wacholder S, Manos MM, Scott DR, Sherman ME, Kurman RJ, Glass AG, Anderson SM, Schiffman M. A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types. J Infect Dis 2001;183:8-15.

20. Gravitt PE, Lacey JV Jr, Brinton LA, Barnes WA, Kornegay JR, Greenberg MD, Greene SM, Hadjimichael OC, McGowan L, Mortel R, Schwartz PE, Zaino R, Hildesheim A. Evaluation of self-collected cervicovaginal cell samples for human papillomavirus testing by polymerase chain reaction. Cancer Epidemiol Biomarkers Prev 2001;10:95-100.


Honors and Awards


2000-02

Cancer Research Training Award Pre-Doctoral Fellowship, EEB, DCEG, NCI, NIH

2002-03

Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention

 

 

 

 

 

Project 1

 

Investigators

 

Keerti Shah

Patti Gravitt

Dorothy Rosenthal

Sudha Sivaram

Richard Daniel

Kathleen Cho

 

Personnel

 

Joy Mays

 

 

 

 

 

 

Copyright © 2004 The Johns Hopkins University. All rights reserved.