Division of Neuropathology

Faculty, Staff & Students

Olga Pletnikova, MD Olga Pletnikova, M.D.
  • Primary Appointment in Pathology

My research activities focus on the neuropathology of normal aging and the pathology of neurodegenerative disorders, such as Alzheimer's, Frontotemporal Dementia, Parkinson's and Lewy body disease and Huntington's disease. I am also the manager of the JHU Brain Resource Center, a large repository of well-characterized postmortem brain samples available to researchers at Hopkins and the research community at large. My experience and activities also include forensic neuropathology.


  1. Pletnikova O, West N, Lee MK, Rudow G, Skolasky RL, Dawson TM, Marsh L, Troncoso JC: Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiology of Aging 26: 1183-92, 2005
  2. Rudnicki DD, Pletnikova O, Vonsattel JP, Ross CA, Margolis RL. A comparison of huntington disease and huntington disease-like 2 neuropathology.J Neuropathol Exp Neurol. 67(4):366-74, 2008.
  3. Johnson MW, Stoll L, Rubio A, Troncoso J, Pletnikova O, Fowler DR, Li L. Axonal Injury in Young Pediatric Head Trauma: A Comparison Study of β-amyloid Precursor Protein (β-APP) Immunohistochemical Staining in Traumatic and Nontraumatic Deaths.* J Forensic Sci. 2011; 56(5): 1198-205. doi:10.1111/j.1556-4029.2011.01814.x. PMID: 21595698.
  4. Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ.Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.Hum Mol Genet. 2012 Jun 1;21(11):2420-31. Epub 2012 Feb 21. PMCID: PMC 3349422
  5. Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK. Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci. 2012; 32(10):3306-20. PMCID: PMC3461828
  6. Majounie E, Abramzon Y, Renton AE, Perry R, Bassett SS, Pletnikova O, Troncoso JC, Hardy J, Singleton AB, Traynor BJ. Hexanucleotide Repeat Expansion in the C9ORF72 gene in Alzheimer's Disease. New England Journal of Medicine. 2012 Jan 19:366(3): 283-4.Epub 2012 Jan 4.
  7. Guo Z, Rudow G, Pletnikova O, Codispoti KE, Orr BA, Crain B, Duan W, Margolis RL, Rosenblatt A, Ross CA, MD, Troncoso JC. Striatal neuronal loss correlates with motor impairment in Huntington's disease. Movement Disorder, 2012