Division of Neuropathology

Publications

Recent

  1. Ames HM, Yuan M, Vizcaíno MA, Yu W, Rodriguez FJ. MicroRNA profiling of low-grade glial and glioneuronal tumors shows an independent role for cluster 14q32.31 member miR-487b. Mod Pathol. 2017 Feb;30(2):204-16.
  2. Lee JK, Wang B, Reyes M, Armstrong JS, Kulikowicz E, Lee J-H, Koehler RC Martin LJ. Hypothermia and rewarming activate a macroglial unfolded protein response independent of hypoxic-ischemic brain injury in neonatal piglets. Dev Neurosci 2016;38(4):277-94.
  3. Ames H, Halushka MK, Rodriguez FJ. miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Application. J Neuropathol Exp Neurol. 2017 Apr 1;76(4):246-54.
  4. Barresi V, Barns D, Grundmeyer Rd R, Rodriguez FJ. Cystic endosalpingiosis of lumbar nerve root: a unique presentation. Clin Neuropathol. 2017 May/Jun;36 (2017)(3):108-13.
  5. Chang Q, Martin LJ. Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS. Neurobiol Dis 2016 Sep;93:78-95.
  6. Eberhart C. Multiple cilia suppress tumour formation. Nat Cell Biol. 2016 Mar 30;18(4):368-9.
  7. Fayzullina S, Martin LJ. DNA Damage response and DNA repair in skeletal Myocytes from a mouse model of spinal muscular atrophy. J Neuropathol Exp Neurol 2016 Sep;75(9):889-902.
  8. Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dancik V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees M, Shamji AF, Schreiber SL, Fraenkel E, Pomeroy SL, Mesirov JP, Tamayo P, Eberhart CG, Raabe EH. DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets. Clin Cancer Res. 2016 Aug 1;22(15):3903-14.
  9. Kaur H, Ali SZ, Huey L, Hütt-Cabezas M, Taylor I, Mao XG, Weingart M, Chu Q, Rodriguez FJ, Eberhart CG*, Raabe EH. The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma. Cancer Lett. 2016 Jul 10;377(1):55-64. (corresponding author)
  10. LaClair KD, Donde A, Ling JP, Jeong YH, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque Β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol 2016 Dec;132(6):859-73.
  11. Li T, Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C, Wong PC. Tau repeat domain facilitates pathological conversion of tau through the neuritic plaque in Alzheimer's mice. Nature Communications 2016 July;7: article # 12082 (open access journal)
  12. Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC. PTBP1 and PTBP2 repress nonconserved cryptic exons. Cell Rep 2016 Sep 27;17(1):104-13.
  13. Martin LJ, Wong M. Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration. Mech Ageing Dev 2017 Jan;161(Pt A):149-62.
  14. Melnikova T, Park D, Becker L, Lee D, Cho E, Sayyida N, Tian J, Bandeen-Roche K, Borchelt DR, Savonenko AV. Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease. Neurobiol Dis 2016 Dec;96:171-85.
  15. Mori S, Kageyama Y, Hou Z, Aggarwal M, Patel J, Brown T, Miller MI, Wu D, Troncoso JC. Elucidation of white matter tracts of the human amygdala by detailed comparison between high-resolution postmortem magnetic resonance imaging and histology. Front Neuroanat 2017 Mar 14;11:16.
  16. Natsumeda M, Maitani K, Liu Y, Miyahara H, Kaur H, Chu Q, Zhang H, D Kahlert U, Eberhart CG. Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres. Brain Pathol. 2016 Nov;26(6):713-23.
  17. Nauen D. Extra-central nervous system target for assessment and treatment in refractory anti-N-methyl-d-aspartate receptor encephalitis. J Critical Care 2017 Feb;37:234-6.
  18. Rodriguez EF, Blakeley J, Langmead S, Olivi A, Tufaro A, Tabbarah A, Berkenblit G, Sacks JM, Newsome SD, Montgomery E, Rodriguez FJ. Low grade Schwann cell neoplasms with leptomeningeal dissemination: clinicopathologic and autopsy findings. Hum Pathol 2017 Feb;60:121.
  19. Rodriguez FJ, Vizcaino MA, Blakeley J, Heaphy CM. Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas. Acta Neuropathol 2016 Nov;132(5):761-3.
  20. Rodriguez FJ, Vizcaino MA, Lin MT. Recent Advances on the Molecular Pathology of Glial Neoplasms in Children and Adults. J Mol Diagn 2016 Sep;18(5):620-34.
  21. Sun M, Bell W, LaClair KD, Ling JP, Han H, Kageyama Y, Pletnikova O, Troncoso JC, Wong PC, Chen LL. Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43. Acta Neuropathol. 2017 Jun;133(6):923-31.
  22. Tabbarah AZ, Robert Bell W, Sun M, Gelwan E, Pletnikova O, Hillis AE, Troncoso JC, Lin MT, Chen L. A rapidly progressive dementia case with pathological diagnosis of FTLD-UPS. Acta Neuropathol. 2016 Aug;132(2):309-11.
  23. Vizcaíno MA, Bishop J, Sharma R, Refaey K, Quiñones-Hinojosa A, Rodriguez FJ. Intracranial solitary fibrous tumor/ hemangiopericytoma with osteoclast-like multinucleated giant cells: comparison with giant cell-rich solitary fibrous tumor. Clin Neuropathol. 2016 Jul-Aug;35(4):171-7.

2016

  1. Pinto AL*, Chen L*, Friedman R, Grant PE, Poduri A, Takeoka M, Prabhu SP, Sahin M. Sturge-Weber syndrome: brain magnetic resonance imaging and neuropathology findings. Pediatr Neurol 2016 May;58:25-30. *Co-first author
  2. Rodriguez O, Schaefer ML, Wester B, Lee YC, Boggs N, Conner HA, Merkle AC, Fricke ST, Albanese C, Koliatsos VE. Manganese-Enhanced Magnetic Resonance Imaging as a Diagnostic and Dispositional Tool after Mild-Moderate Blast Traumatic Brain Injury. J Neurotrauma. 2016 Apr 1;33(7):662-71.
  3. Suarez MJ, Rivera-Michlig R, Dubovy S, Rodriguez FJ. Clinicopathologic Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum. Ocul Oncol Pathol Apr-June 2016;2:112-21.
  4. Asch-Kendrick RJ, Burton E, Chen L, Nauen D. A 74-year-old man with a jugular foramen mass. Brain Pathol 2016 Jan;26(1):124-5.
  5. Eberhart C. Multiple cilia suppress tumour formation. Nat Cell Biol. 2016 Mar 30;18(4):368-9.
  6. Kahlert UD, Cheng M, Koch K, Marchionni L, Fan X, Raabe EH, Maciaczyk J, Glunde K, Eberhart C. Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells. Int J Cancer 2016 Mar ;138(5):1246-55.
  7. Nauen D, Haley L, Lin MT, Perry A, Giannini C, Burger PC, Rodriguez FJ. Molecular analysis of pediatric oligodendrogliomas highlights genetic differences with adult counterparts and other pediatric gliomas. Brain Pathol 2016 Mar;26(2):206-14.
  8. Rodriguez FJ. N for nucleus in neurofibromin: new role for an old tumor suppressor? J Neurochem 2016 Jan;136(1):11-2.

2015

  1. Brandt WD, Schreck KC, Bar EE, Taylor I, Marchionni L, Raabe E, Eberhart CG, Rodriguez FJ. Notch signaling activation in pediatric low-grade astrocytoma. J Neuropathol Exp Neurol 2015 Feb;74(2):121-31.
  2. Eberhart CG, Orr BA. Molecular pathways: not a simple tube-the many functions of blood vessels. Clin Cancer Res 2015 Jan;21(1):18-23.
  3. Ho CY, Mobley BC, Gordish-Dressman H, VandenBussche CJ, Mason GE, Bornhorst M, Esbenshade AJ, Tehrani M, Orr BA, LaFrance DR, Devaney JM, Meltzer BW, Hofherr SE, Burger PC, Packer RJ, Rodriguez FJ. A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation. Acta Neuropathol. 2015 Oct;130(4):575-85.
  4. Ho CY, Mosier S, Safneck J, Salomao DR, Miller NR, Eberhart CG, Gocke CD, Batista DA, Rodriguez FJ. Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma. Brain Pathol 2015 Mar;25(2):193-201.
  5. Iacono D, Zandi P, Gross M, Markesbery WR, Pletnikova O, Rudow G, Troncoso JC. APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study. Oncotarget. 2015 Jun 10;6(16):14082-91.
  6. Kahlert UD, Suwala AK, Koch K, Natsumeda M, Orr BA, Hayashi M, Maciaczyk J, Eberhart CG. Pharmacologic Wnt inhibition reduces proliferation, survival, and clonogenicity of glioblastoma cells. J Neuropathol Exp Neurol. 2015 Sep;74(9):889-900.
  7. Kahlert UD, Suwala AK, Raabe EH, Siebzehnrubl FA, Suarez MJ, Orr BA, Bar EE, Maciaczyk J, Eberhart CG. ZEB1 promotes invasion in human fetal neural stem cells and hypoxic glioma neurospheres. Brain Pathol 2015 Nov;25(6):724-32.
  8. Lauterbach MD, Notarangelo PL, Lane KS, Koliatsos VE. Treatment of traumatic brain injury-induced dyskinesia with tetrabenazine: a case report. Psychosomatics 2015 Sep-Oct;56(5):567-71.
  9. Lim KJ, Brandt WD, Heth JA, Muraszko KM, Fan X, Bar EE, Eberhart CG. Lateral inhibition of Notch signaling in neoplastic cells. Oncotarget 2015 Jan 30;6(3):1666-77.
  10. Ling JP, Pletnikova O, Troncoso JC, Wong PC. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science 2015 Aug 7;349(6248):650-5.
  11. Pletnikova O, Rudow GL, Hyde TM, Kleinman JE, Ali SZ, Bharadwaj R, Gangadeen S, Crain BJ, Fowler DR, Rubio AI, Troncoso JC. Alzheimer lesions in the autopsied brains of people 30 to 50 years of age. Cogn Behav Neurol. 2015 Sep;28(3):144-52.
  12. Rodriguez FJ, Schniederjan MJ, Nicolaides T, Tihan T, Burger PC, Perry A. High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). Acta Neuropathol 2015 Apr;129(4):609-10.
  13. Savonenko AV, Melnikova T, Wang Y, Ravert H, Gao Y, Koppel J, Lee D, Pletnikova O, Cho E, Sayyida N, Hiatt A, Troncoso J, Davies P, Dannals RF, Pomper MG, Horti AG. Cannabinoid CB2 receptors in a mouse nodel of Αβ amyloidosis: immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation. PLoS One. 2015 Jun 18;10(6):e0129618.
  14. Shyam R, Ren Y, Lee J, Braunstein KE, Mao HQ, Wong PC. Intraventricular delivery of siRNA nanoparticles to the central nervous system. Mol Ther Nucleic Acids 2015 May 12;4:e242.
  15. Sun M, Oulabi I, Chen L. CRISPR/Cas9 genome editing system in Drosophila. Adv Tech Biol Med 2015 Sept;S1:003.
  16. Sun M, Chen L. Studying tauopathies in Drosophila: a fruitful model. Exp Neurol. 2015 Dec;274(Pt A):52-7.
  17. Vizcaíno MA, Shah S, Eberhart CG, Rodriguez FJ. Clinicopathologic implications of NF1 gene alterations in diffuse gliomas. Hum Pathol 2015 Sep;46(9):1323-30.
  18. Xu L. Animal model of repetitive mild traumatic brain injury for human traumatic axonal injury and chronic traumatic encephalopathy. Neural Regen Res 2015 Dec;10(11):1731-2