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Alzheimer's Disease Research - Alena Savonenko, M.D., Ph.D.

Monoclonal Antibodies for Alzheimer's Immunotherapy

Through a grant provided by MAPP Biopharmaceutical, Inc., Dr. Savonenko will study the behavioral and histological effects of different anti-Aβ antibodies produced by transgenic plants for passive immunization in Alzheimer's mouse models at different stages of a disease progression.

Up to five anti-amyloid peptide monoclonal antibodies for the prevention or treatment of Alzheimer's disease (AD) will be provided by Mapp Biopharmaceutical, Inc. They will be evaluated at JHU under the supervision of Dr. Alena Savonenko and Dr. Juan Troncoso. The evaluation will consist of injecting the APPswe/PS1ΔE9 transgenic mouse model of AD in acute regimens at high doses followed by a variety of tasks to assess effects on cognitive function. These will consist of place discrimination, repeated reversals, radial water maze and visual discrimination tasks. In addition, free and deposited brain peptide will be measured as well as the extent and severity of brain microhemorrhages.