Anatomic Pathology Consult Page

Urologic Pathology

The Urologic Pathology Laboratory is a nationally recognized center for the study of urologic disorders. We are known in particular for our vast expertise in the study and diagnosis of the pathology of prostate cancer. We consult with pathologists and clinicians throughout the United States as well as overseas, reviewing as many as 15,000 cases a year. Because of this extensive experience, we can provide accurate diagnoses and second opinions as well as sound recommendations for treatment management.

Lab Hours

5:30 a.m. to 4:30 p.m., Monday through Friday.

Johns Hopkins Medical Institutions
Anatomic Pathology Consultation Service

1620 McElderry Street
Reed Hall, Room 315
Baltimore, MD 21205
Phone 410-955-5043
Fax 443-287-3818


The Urological Pathology Consult Division was established in the mid-1980s when Dr. Jonathan Epstein joined the staff at The Johns Hopkins Hospital. In addition to our unparalleled volume of consult work with prostate needle biopsies, division staff sees more than 1000 radical prostatectomies yearly. Our experience in evaluating these specimens helps physicians predict patient prognosis following radical prostatectomy.

We also provide valuable support to pathologists and physicians in the form of second opinions. Our expert evaluation can provide a more accurate grading of malignancies, enabling clinicians to treat their patients more effectively. A recent study demonstrates the utility of second opinion -- despite confidence in the initial diagnosis: For 1% of men coming to Hopkins for radical prostatectomies, our second opinion review reversed the diagnosis of cancer made outside this hospital and saved these men from major surgery.

Indicative of Dr. Epstein's interest and expertise in all aspects of urologic pathology are his books on Prostate Biopsy Interpretation and Bladder Biopsy Interpretation. He is also an editor of the World Health Organization (WHO) book on WHO Classification of Tumours : Pathology and Genetics. Tumours of the Urinary and Male Reproductive System. Dr. Epstein was the leading author on The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma and The World Health Organization/International Society of Urological Pathology Consensus Classification of Urothelial (Transitional Cell) Neoplasms of the Urinary Bladder.

Dr. Netto's strong interest and expertise in urologic pathology is reflected by his over 15 years experience in the histologic interpretation of surgical pathology specimens from the various urologic and male genital organs. Together with Dr. Epstein, He is the coauthor of the fourth edition of "Prostate Biopsy Interpretation", one of the most widely distributed books in the field. Dr. Netto's background in Molecular Diagnostics has been applied to his active research in the investigation of molecular biomarkers for the tumors of the Urinary and Male Reproductive System that could serve as new prognosticators and potential targets of future therapies.


Expert Consultation
Dr. Jonathan Epstein, a recognized leader in the field of urological pathology, is the division's primary consultant. He was one of the first investigators to develop a methodical approach to diagnosing limited adenocarcinoma of the prostate on needle biopsy. He lectures widely in the United States and overseas on urological pathology, with emphasis on prostatic and bladder disease, and has written several books and more than 700 articles.

In addition to his expertise in pathology, Dr. Epstein is knowledgeable about various treatment options for prostatic disease. He consults frequently with pathologists, referring physicians and patients about treatment management options.

Dr. George Netto is the second consultant in the division. He enjoys a rising recognition in the field of genito-urinary pathology and had lectured in several national and international meetings on the diagnostic and molecular aspects of urologic pathology. Dr. Netto's diagnostic experience stems from rendering consultations on thousands of genito-urologic second opinion cases sent to Hopkins from national and international practitioners and patients.

Special capabilities and services
We perform stains off paraffin blocks as well as by destaining the H&E section and staining a portion of the H&E slide.

Timely Results

Written reports of results are faxed to contributors within 24 to 48 hours. When requested, Drs. Epstein and Netto talk to physicians and patients to discuss the results and recommendations for treatment management.


Dr. Jonathan Epstein

Jonathan I. Epstein, M.D.

Phone: 410-614-6330
Fax: 443-287-3818

Education and Training

Professional Interests
Prostatic intraepithelial neoplasia; adenosis; diagnosis of limited adenocarcinoma on needle biopsy; prediction of disease progression following radical prostatectomy.

Notable Accomplishments
Recipient of the Arthur Purdy Stout Surgical Pathology Award in 1996 and American Cancer Society Clinical Oncology Career Development Award.

Major Professional Leadership

Dr. George Netto

George J. Netto, M.D.

Phone: 410-955-5082
Fax: 443-287-3818

Education and Training

Professional Interests
Prostatic intraepithelial neoplasia; Secondary tumors of the GU system; Prognostic and Targeted Therapy
Biomarkers discovery in Tumors of bladder and kidney

Major Professional Leadership

Dr. Tamara Lotan

Tamara L. Lotan, M.D.

Phone: 410-614-9196
Fax: 410-502-9911

Education and Training

Professional Interests

Prostate carcinoma and its variants (ductal adenocarcinoma, small cell carcinoma); micropapillary carcinoma and adenocarcinoma of the bladder

Notable accomplishments


To order, call Customer Service at 1-800-997-5475 between 8:00 a.m. and 11:00 p.m.

Interpretations of urological pathology specimens are provided by experienced specialists

Standard Specimen Processing
The laboratory provides expert evaluation of urological pathology specimens, using light microscopy with immunohistochemistry and/or electron microscopy as appropriate for each case. Studies can be done on tissue or on blocks of slides prepared elsewhere.


Light microscopy (LM)

Immunohistochemistry - Triple cocktail stain for HMWCK/p63/AMACR, others as needed

Turnaround time is routinely 24 to 48 hours. Slides sent for consultation are returned automatically to contributors within two weeks.

Special Ordering Instructions

Forward slides by courier or express mail to:
Johns Hopkins Medical Laboratories
1620 McElderry Street
Reed Hall Rm 315
Baltimore, MD 21205
Phone 410-955-2405
Fax 410-367-2404