Anatomic Pathology Consult Page


Supplementary Table: Gleason Score 3+4 vs. 4+3: Correlation of Biopsy and Radical Prostatectomy Grade

Biopsy Grade RP Grade No. of Cases Author Years of Study
3+4=7
4+3=7		 26.7% upgraded
53.3% downgraded		 217
60		 Burdick13 1996-2005
3+4=7
4+3=7		 35% upgraded
49% downgraded		 148
57		 Grober14 1997-2001
3+4=7
4+3=7		 29% upgraded
51% downgraded		 201
78		 Kang15 1988-2005
3+4=7
4+3=7		 33% upgraded
33% downgraded		 52
27		 Fanning16 2003-2008
3+4=7
4+3=7		 28% upgraded
33% downgraded		 112
3		 D'Amico21 1988-1997
3+4=7
4+3=7		 44% upgraded
48% downgraded		 25
25		 King20 2000-2003
3+4=7 25% upgraded 216 Freedland17 1996-2005
3+4=7
4+3=7		 27% upgraded
36% downgraded		 734
226		 Moussa18 2000-2007
3+4=7 55% upgraded 181 Tilki19 2004-2007
3+4=7
4+3=7		 26% upgraded
40% downgraded		 1267
524		 Current 2004-2010

Relation of Radical Prostatectomy Tumor Volume to Post-Operative Progression

Institution(yr) No. Cases Yrs of Study Mean f.u. mos. Totally embedded T. vol parameter Mean t.vol. cc.(median) Independent predictor
U.Miami(2003) 692 1992-2002 52 Yes Percent (estimate)   Yes
U.Innsbruck(2006) 102 1988-2005   Yes Volume (planimetry) 1.27 Yes
Vanderbilt(2006) 431 2000-2002 25.4 Yes Volume (planimetry) 3.28 Yes
Vivantes Hospitals(2007) 528 1996+2003 48.8 (46.4) Yes Volume (planimetry) 4 Yes
U.Heidelberg(2007) 506 1999-2006 37.3   Volume (?Technique) 3.58(no prog) 3.3(prog) Yes
U.Hamburg(2007) 780 1996-2003 46.7 (43.4) No Volume (planimetry) 6.6 Yes
Keio U.(2009) 164     Yes Volume MTD 3.9 Yes
Stanford(2009) 739 1984-2004 (91.7) Yes Volume (planimetry) (2.4) Yes
U. of Tokyo(2010) 364 2000-2009 (37.4) Yes MTD   Yes
Duke U.(2010) 3057 1988-2008   Yes Percent Volume (estimated)   No
Indiana U.(2005) 364   (12) No MTD 2.5 Yes
Indiana U.(2005) 459   44.3 No Percent (Visual Estimate) 24%(no prog) 36%(prog) No
Henri Mondor Hospital(2003) 200 1992-1998 64 Yes Volume (planimetry) 1.35 No
Baylor(2004) 1302 1983-2000 (46) Yes Volume (planimetry) (2.16 Pre '95) (1.25 Post '95) No
Brigham & Women's(2005) 781 1986-2002 65 No MTD   No
Nijmegen(2008) 542 1992-2005 (39.5) Yes Volume (planimetry) MTD (2.0) No
UCSF(2009) 856 1998-2007 24(no prog) Yes Volume (estimate) (1.5) No
U.Western Australia(2010) 2385 1998-2007 32.3 (no prog) Yes Volume (planimetry) 3.4 No
U.Campinas(2010) 305 1997-2008 30.2 Yes Volume (point count)   No
Erasmus(2010) 305 1993-2000 96 (98) Yes Volume (planimetry) 1.05
(0.6)		 No

Multivariate Analyses Predicting Progression Following Radical Prostatectomy

Institution Tumor Volume,
Gleason Score,
PSA		 EPE,
Margins,
Age		 SVI, LN
U.Miami Tumor volume p=0.017-0.001
Gleason score p=NS - 0.018**
PSA (>10) p=0.005		 EPE p<0.0001
Margins p=NS
Age p=0.02-.005		 SVI p=0.021
LN p=NS
Innsbruck Tumor volume p<0.001
Gleason score p<0.05		 pStage p<0.001
Margins p<0.045		 SVI p<0.05
Vanderbilt Tumor volume p=0.04
Gleason score p=0.005
PSA p=NS		 pStage p=NS
Margins p=0.008		 LN p=0.04
Vivantes Tumor volume p=NS
Gleason score p<0.001		 pStage p=NS
Margins p=NS		 LN p=0.008
Hamburg Tumor volume p=0.002
Gleason score p<0.001=
PSA p=0.023		 EPE p<0.001
Margins p=NS		 SVI p=NS
LN p=0.042
Keio Tumor volume p=0.015
Gleason score p=0.013		 pStage p=NS
Margins p=0.005		  
Stanford Tumor volume p=0.01
Gleason score p<0.001
PSA p=NS		 EPE p<0.001
Margins p<0.001		 SVI p=NS
LN p<0.001
Duke Tumor volume p=0.031
Gleason score p<0.001
PSA p<0.001		 pStage=0.05
Margins p<0.001		 SVI p<0.001
Indiana Tumor volume p=0.011
Gleason score p<0.0001		 pStage p=NS
Margins p=NS		 SVI p=NS
Tokyo Tumor volume p=0.037
Gleason score p=0.019		 pStage p=0.003
Margins p<0.001		  
Mondor Tumor volume p=NS
Gleason score p=0.04		 pStage p=0.0002
Margins p=NS		  
Baylor Tumor volume p=NS
Gleason score p<0.001		 EPE p<0.001
Margins p=NS		 SVI p<0.001
LN p<0.001
Brigham & Women's Tumor volume p=NS
Gleason score p<0.0001
PSA p<0.0001		 EPE p=NS
Margins p=0.0004		 SVI p<0.0001
Nigmegen Tumor volume p=NS
Gleason score p<0.05*		 pStage p<0.05*
Margins p<0.05		  
UCSF Tumor volume p=NS
Gleason score p=0.001
PSA (>10) p=0.02-0.001		 EPE p=0.004
Margins p=0.042		 SVI p=0.034
LN p=NS
U.Western Australia Tumor volume p=NS
Gleason score p<0.001
PSA p=0.001		 EPE p<0.001
Margins p<0.001		 SVI p<0.001
Campinas Tumor volume p=NS
Gleason score p=0.01		 pStage p=0.03
Margins p<0.01		  
Erasmus Tumor volume p=NS
Gleason score p<0.0001
 pStage p=NS
Margins p<0.0001
Age p=0.008		 SVI p=NS

** Range of p values for various outcomes relative to reference value
* Only p values greater or less than 0.05 were reported