Graduate Program in Pathobiology

Support the Program

Faculty and Administration

Baxley Professor and Director, Department of Pathology Ralph H. Hruban, M.D.
Program Director, Pathobiology Lee J. Martin, Ph.D.
Program Co-Director, Pathobiology Tamara Lotan, M.D.
Admissions Committee Chair Karen Sfanos, Ph.D.
Curriculum Committee Chairs Lee Martin, Ph.D.
Tamara Lotan, M.D.
Journal Club Committee Chairs Saraswati Sukumar, Ph.D.
Harry (Ben) Larman, Ph.D.
Ombudsmen James Eshleman, M.D., Ph.D.
Saraswati Sukumar, Ph.D.
Program Coordinator

Fields of Study and Research

The Graduate Program in Pathobiology provides students with opportunities to probe the mechanisms and origins of human disease through an integrative approach emphasizing systemic processes and their molecular and cellular pathologic underpinnings. Students are prepared for academic research, teaching, and biotechnology careers in one of seven programmatic areas: Cellular & Molecular Pathology; Immunopathology; Microbiology & Infectious Disease; Neoplasia; Neuropathology; and Cardiovascular Disease.


Faculty in the program have diverse interests united by a focus upon human disease.

Faculty and their Research InterestsCritical Publications
Richard Ambinder, M.D., Ph.D. Richard Ambinder, M.D., Ph.D.
Professor, Oncology

Lymphoma; Viral Carcinogenesis
Robert A. Anders, M.D., Ph.D. Robert A. Anders, M.D., Ph.D.
Associate Professor, Pathology - GI/Liver Pathology

Liver Biology; Growth Control and Immunology
Stephen B. Baylin, M.D. Stephen B. Baylin, M.D.
Professor, Oncology

Cancer; Genetics
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Buhu S, Slamon DJ, Wolchok JD, Pardoll DM, Beckmann MW, Zahnow CA, Mergoub T, Chan TA, Baylin SB, Strick R. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell 162, 974-986 2015.

Jones PA, Issa J-P J, Baylin SB. Targeting the cancer epigenome for therapy. Nat Rev Genet. 2016 Sept15;17(10):630-41.
William Bishai, M.D., Ph.D. William Bishai, M.D., Ph.D.
Professor, Dept. of Medicine, Infectious Disease Co-Director, Center for Tuberculosis Research

Molecular pathogenesis of tuberculosis
Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR. A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis. Nat Med. 2015;21:401-6. PMID: 25730264.

Rifat D, Prideaux B, Savic RM, Urbanowski ME, Parsons TL, Luna B, Marzinke MA, Ordonez AA, DeMarco VP, Jain SK, Dartois V, Bishai WR, Dooley KE. Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data. Sci Transl Med. 2018;10: eaai7786. PMID: 29618565.
Shyam Biswal, M.S., Ph.D. Shyam Biswal, M.S., Ph.D. - Research Lab
Professor, Environmental Health Sciences & Medicine

Nrf2-Keap1 stress response pathway in lung cancer and COPD; Host immune response
Fred Bunz, M.D., Ph.D. Fred Bunz, M.D., Ph.D.
Associate Professor, Radiation Oncology, Oncology

DNA damage signaling and the roles of p53 in tumor suppression
J. Miciak, F. Bunz. Long story short: p3 mediates innate immunity. Biochimica et Biophysica Acta 1865 (2016) 220-227.

J. H. Chung, A. R. Larsen, E. Chen, and F. Bunz. A PTCH1 Homolog Transcriptionally Activated by p53 Suppresses Hedgehog Signaling. The Journal of Biological Chemistry, Vol. 289, No. 47, pp. 33020-33031, Nov. 21, 2014.
Irina Burd, M.D., Ph.D. Irina Burd, M.D., Ph.D.
Associate Professor of Gynecology and Obstetrics and Neurology; Director of Research, Maternal Fetal Medicine

Fetal Medicine; Fetal Neurology; Reproductive Biology
Patrizio Caturegli, M.D. Patrizio Caturegli, M.D. - Autoimmune Disease website
Professor and Director, Immunopathology

Immunopathology; Autoimmunity; Thyroiditis
Daniela Čiháková, M.D., Ph.D. Daniela Čiháková, M.D., Ph.D. - Research Lab
Associate Professor, Immunology

Cardiac immunology - myocarditis, myocardial infarction, cardiac transplant; autoimmune diseases-Sjogrens's syndrome
Wu L, Ong S, Talor MV, Jobert G. Barin JG, Baldeviano GC, Kass DA, Bedja D, Zhang H, Sheikh A, Margolick JB, Iwakura5 Y, Rose NR, and Čiháková D*. Cardiac Fibroblasts Mediate IL-17A-Driven Inflammatory Dilated Cardiomyopathy. Journal of Experimental Medicine. 2014; 211(7):1449-64. PMID: 24935258.

Diny NL, Baldeviano GC, Talor MV, Barin JG, Ong S, Bedja D, Hays GH, Gilotra NA, Coppens I, Rose NR, and Čiháková D. Eosinophil-derived IL4 drives progression of myocarditis to inflammatory dilated cardiomyopathy. Journal of Experimental Medicine, 2017; 214(4):943-957
Isabelle Coppens, Ph.D. Isabelle Coppens, Ph.D.
Professor, Molecular Microbiology and Immunology, School of Public Health

Intracellular Parasitism; Apicomplexa-mammalian Cell Interactions
Coppens, I. Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies. Nat. Rev. Microbiol. (2013)11:823-835.

Lige B, Sampels, V and Coppens, I. Characterization of a second sterol-esterifying enzyme Toxoplasma highlights the importance of cholesterol storage pathways for the parasite. Mol. Microbiol. (2013) 87:951-967.
Angelo DeMarzo, M.D., Ph.D. Angelo DeMarzo, M.D., Ph.D. - Research Lab
Professor of Pathology

Cancer Biology; Prostate Cancer
Charles Drake, M.D., Ph.D. Charles Drake, M.D., Ph.D.
Director, GU Oncology, Columbia University Medical Center

Tumor Immunology; GU Cancer; Melanoma
Drake, C. "Consultation corner. Prostate cancer vaccine offers new direction.." Johns Hopkins Med Lett Health After 50

Getnet, D., Grosso, J. F., Goldberg, M. V., Harris, T. J., Yen, H. R., Bruno, T. C., Durham, N. M., Hipkiss, E. L., Pyle, K. J., Wada, S., Pan, F., Pardoll, D. M., Drake, C. G. "A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.." Mol Immunol
Charles G. Eberhart, M.D., Ph.D. Charles G. Eberhart, M.D., Ph.D.
Professor of Pathology, Ophthalmology and Oncology

Biology of brain and eye tumors
Asnaghi L, Tripathy A, Yang Q, Kaur H, Hanaford A, Yu W, Eberhart CG. Targeting Notch signaling as a novel therapy for retinoblastoma. Oncotarget 2016; 7(43):70028-70044

Lim KJ, Brandt WD, Heth JA, Muraszko KM, Fan X, Bar EE, Eberhart CG. Lateral inhibition of Notch signaling in neoplastic cells. Oncotarget 2015 Jan 30;6(3):1666-77. PMID: 25557173
James R. Eshleman, M.D., Ph.D. James R. Eshleman, M.D., Ph.D.
Ralph H. Hruban, M.D. Professor in Pancreatic Cancer Research, GI/Liver Pathology
Professor, Pathology - GI/Liver Pathology

Pancreatic cancer; early detection; familial predisposition; novel molecular tools
Norris AL, Kamiyama H, Makohon-Moore A, Pallavajjala A, Morsberger LA, Lee K, Batista D, Iacobuzio-Donahue CA, Lin MT, Klein AP, Hruban RH, Wheelan SJ, Eshleman JR. TransFlip mutations produce deletions in pancreatic cancer. Genes, Chromosomes and Cancer. August, 2015, 54: 472-481.

Norris AL, Workman RE, Fan Y, Eshleman JR*, Timp W*. [*Co-Senior authors] Nanopore sequencing detects structural variants in cancer. Cancer Biol Ther. 2016 Mar; 17:246-53.
Susan H. Eshleman, M.D., Ph.D. Susan H. Eshleman, M.D., Ph.D.
Professor, Pathology - Transfusion Medicine

Virology; HIV
Coates TJ, Kulich M, Zelaya CE, Celantano DD, Chariyalertsak S, Chingono A, Gray G, Mbwambo JKK, Morin FS, Richter L, Sweat M, van Rooven H, McGrath N, Fiamma A, Laeyendecker O, Piwowar-Manning E, Szerekes G, Donnell D, and Eshleman SH. Effect of community-based voluntary counselling and testing on HIV incidence and social and behavioural outcomes (NIMH Project Accept; HPTN 043): a cluster-randomised trial. Lancet Global Health. 2014. 2:e267-e277.

Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour M, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto J, Godbole SV, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Cottle L, Zhang XC, Makhema J, Mills LA, Panchia R, Faesen S, Eron J, Gallant J, Havlir D, Swindells S, Elharrar V, Burns D, Taha TE, Nielse-Saines K, Celentano DD, Essex M, Hudelson SE, Redd AD, and Fleming TR. Antiretroviral treatment for prevention of HIV transmission: The final results of the HIV Prevention Trials Network (HPTN) 052 trial. New Eng J Med. 9/2016; 375:830-9.
Mohamed H. Farah, Ph.D. Mohamed H. Farah, Ph.D.
Associate Professor, Departments of Neurology and Neuroscience

Peripheral Nerve Regeneration
Tallon C, Russell KA, Sakhalkar S, Andrapallayal A, Farah MH. Length-dependent axo-terminal degeneration at the neuromuscular synapses of type II muscle in SOD1 mice. Neuroscience. 2016 Jan 15;312:179-89. Epub 2015 Nov 18.

Tallon C, Rockenstein E, Masliah E, Farah MH. Increased BACE1 activity inhibits peripheral nerve regeneration after injury. Neurobiol Dis. 2017 Jul 5;106:147-157. doi: 10.1016/j.nbd.2017.07.003.
Alan D. Friedman, M.D. Alan D. Friedman, M.D.
Professor, Oncology

Transcriptional control of hematopoiesis; stem cells; leukemic transformation; immunotherapy
Leong WJ, Guo H, Ma O, Huang H, Cantor AB, Friedman AD. Runx1 phosphorylation by Src increases trans-activation via augmented stability, reduced HDAC binding, and increased DNA affinity, and activated Runx1 favors granulopoiesis. J. Biol. Chem., 2016; 291:826-36.

Guo H, Cooper C, Friedman AD. In vivo deletion of the Cebpa +37 kb enhancer markedly reduces Cebpa mRNA in myeloid progenitors but not in non-hematopoietic tissues to impair granulopoiesis. PLoS One 2016; 11(3):e0150809.
Edward W. Gabrielson, M.D. Edward W. Gabrielson, M.D.
Professor, Pathology

Cancer biology; genomics
Kathleen L. Gabrielson, D.V.M., Ph.D. Kathleen L. Gabrielson, D.V.M., Ph.D.
Associate Professor, Molecular and Comparative Pathology

Cancer Therapy; Signal Transduction
Lucio Gama, Ph.D. Lucio Gama, Ph.D.
Assistant Professor, Molecular and Comparative Pathology

Similarities between simian and human immunodeficiency virus (SIV and HIV) and monocytes in infectious diseases
Luis Garza, M.D., Ph.D. Luis Garza, M.D., Ph.D.
Associate Professor, Dermatology

Wound Healing, Regeneration
Nelson AM, Reddy SK, Ratliff TS, Hossain MZ, Katseff AS, Zhu AS, Chang E, Resnik SR, Page C, Kim D, Whittam AJ, Miller LS, Garza LA. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration. Cell Stem Cell. 2015 Aug 6;17(2):139-51. doi: 10.1016/j.stem.2015.07.008. PMID: 26253200

Kim D, Hossain MZ, Nieves A, Gu L, Ratliff TS, Mi Oh S, Park A, Han S, Yang NB, Qi J, Taube JM, Kang S, Garza LA. To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease. Am J Pathol. 2016 May;186(5):1140-50. doi: 0.1016/j.ajpath.2015.12.030. PMID: 27105735
Michael Goggins, M.D. Michael Goggins, M.D.
Sol Goldman Professor of Pancreatic Cancer Research; Pathology - GI/Liver Pathology

Biology and Genetics of Pancreatic Cancer
Shindo K, Yu J, Suenaga M, Fesharakizadeh S, Cho C, Macgregor-Das A, Siddiqui A, Witmer PD, Tamura K, Song TJ, Navarro Almario JA, Brant A, Borges M, Ford M, Barkley T, He J, Weiss MJ, Wolfgang CL, Roberts NJ, Hruban RH, Klein AP, Goggins M. Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2017, 35:3382-90.

Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, MacGregor-Das A, Borges M, Wolfgang CL, Weiss MJ, He J, Canto MI, Petersen GM, Gallinger S, Syngal S, Brand R, Rustgi A, Olson S, Stoffel E, Cote ML, Zogopoulos G, Potash J, Goes FS, McCombie RW, Zandi PP, Pirooznia M, Kramer M, Parla J, Eshleman JR, Roberts NJ, Hruban RH, Klein AP, Goggins M. Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer PNAS 2018: epub 4/18/2018.
Marc Halushka, M.D., Ph.D. Marc Halushka, M.D., Ph.D. - Research Lab
Professor, Pathology

Diabetic Vascular Disease
McCall MN, Kim MS, Adil M, Patil AH, Lu Y, Mitchell CJ, Leal-Rojas P, Xu J, Kumar M, Dawson VL, Dawson TM, Baras AS, Rosenberg AZ, Arking DE, Burns KH, Pandey A, Halushka MK. Toward the human cellular microRNAome. Genome Res. 2017 Oct;27(10):1769-1781.

Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria. Cardiovasc Pathol. 2016 May-Jun;25(3):247-57. doi: 10.1016/j.carpath.2016.03.002. Epub 2016 Mar 12. Review. PMID: 27031798
Abdel Rahim A. Hamad, D.V.M., Ph.D. Abdel Rahim A. Hamad, D.V.M., Ph.D. - Research Lab
Associate Professor, Pathology - Immunopathology

Immunology; T cell activation
G Fousteri, E Ippolito, R Ahmed, ARA Hamad. Beta-cell specific autoantibodies: Are they just an indicator of type 1 diabetes? Current diabetes reviews 13 (3), 322-329.

A Saxena, H Yagita, TW Donner, ARA Hamad. Expansion of FasL-Expressing CD5+ B Cells in Type 1 Diabetes Patients. Frontiers in Immunology 8.
Gary S. Hayward, Ph.D. Gary S. Hayward, Ph.D.
Professor, Oncology

Virology; CMV; herpes viruses
Ahmet Höke, M.D., Ph.D. Ahmet Höke, M.D., Ph.D.
Professor, Neurology and Neuroscience

Mechanisms of peripheral neuropathies; developing treatments for nerve regeneration and neuroprotection
Jing Zhu, Valentina Alda Carozzi, Nicole Reed, Ruifa Mi, Paola Marmiroli, Guido Cavaletti & Ahmet Höke. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016 Jun 28;6:28861. doi: 10.1038/srep28861

Zhu J, Chen W, Mi R, Zhou C, Reed N, Höke A. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74(6):893-904. doi: 10.1002/ana.24004
Robert Ivkov, M.Sc., Ph.D. Robert Ivkov, M.Sc., Ph.D.
Associate Professor, Radiation Oncology and Molecular Radiation Sciences

Development, characterization, and use of nanomaterials to target cancer; Selective heating with magnetic nanoparticles
Sanjay Jain, M.D. Sanjay Jain, M.D.
Professor, Pediatrics and International Health

TB Pathogenesis, Molecular Imaging for Infectious Diseases; Childhood TB
Aaron James, M.D., Ph.D. Aaron James, M.D., Ph.D. - Research Lab
Professor, Surgical Pathology

Bone biology; Osteogenesis; Skeletal repair; Mesenchymal stem cells; Osteosarcoma
James AW, Zara JN, Zhang X, Askarinam A, Goyal R, Chiang M, Yuan W, Chang L, Corselli M, Shen J, Pang S, Stoker D, Ting K, Peault B, Soo C. Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Transl Med, Jun 2012; 1(6): 510-9. PMCID: PMC3659717

James AW, Zara JN, Corselli M, Askarinam A, Zhou AM, Hourfar A, Nguyen A, Megerdichian S, Asatrian G, Pang S, Stoker D, Zhang X, Wu B, Ting K, Peault B, Soo C. An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Transl Med, Sep 2012; 1(9): 673-84. PMCID: PMC3659737
Richard J. Jones, M.D. Richard J. Jones, M.D.
Professor, Oncology

Cancer lymphoma; bone marrow transplantation
Petros Karakousis, M.D. Petros Karakousis, M.D.
Professor of Medicine, Infectious Diseases

Mycobacterium tuberculosis latency and reactivation; TB diagnostics; TB chemotherapy;
Dutta NK, He R, Pinn ML, He Y, Burrows F, Zhang Z-Y, Karakousis PC. Mycobacterial protein tyrosine phosphatases A and B inhibitors augment the bactericidal activity of standard anti-TB regimen. ACS Infect Dis. 2016;2:231-239.

Chuang YM, Dutta NK, Hung CF, Wu TC, Rubin H, Karakousis PC. The stringent response factors PPX1 and PPK2 play an important role in Mycobacterium tuberculosis metabolism, biofilm formation, and sensitivity to isoniazid in vivo. Antimicrob Agents Chemother. 2016; 60:6460-6470. PMCID: PMC5075050.
David A. Kass, M.D. David A. Kass, M.D. - Research Lab
Professor, Medicine - Cardiology

Molecular pathophysiology of heart failure; new treatment modalities; cardiac muscle mechanics
Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA. Pacemaker-induced transient asynchrony suppresses heart failure progression. Sci Transl Med. 2015 Dec 23;7(319):319ra207.

Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA. Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature. 2015 Mar 26;519(7544):472-6.
Scott E. Kern, M.D. Scott E. Kern, M.D.
Professor, Oncology

Cancer; pancreatic cancer genetics
Kwang Sik Kim, M.D. Kwang Sik Kim, M.D.
Professor, Pediatrics - Infectious Diseases

Microbiology; genetics of bacterial pathogenesis blood-brain barrier
Wang X, Maruvada R, Morris AJ, Liu JO, Wolfgang MJ, Baek DJ, Bittman R, Kim KS. Sphingosine 1-phosphate activation of EGFR as a novel target for meningitic Escherichia coli penetration of the bloodÔÇôbrain barrier. PLoS Pathog. 12:e1005926, 2016. PMID: 27711202. PMC5053521

Zhao WD, Liu DX, Wei JY, Miao ZW, Zhang K, Su ZK, Zhang XW, Li Q, Fang WG, Qin XX, Shang DS, Li B, Li QC, Cao L, Kim KS, and Chen YH. Caspr1 is a host receptor for meningitis-causing Escherichia coli. Nat Commun 2018 (in press)
Vassilis E. Koliatsos, M.D. Vassilis E. Koliatsos, M.D. - Research Lab
Professor, Pathology - Neuropathology

Neuropathology; neurodegenerative disease; stroke
Xu L, Nguyen JV, Lehar M, Menon A, Rha E, Arena J, Ryu J, Marsh-Armstrong N, Marmarou CR, Koliatsos VE. Repetitive mild traumatic brain injury with impact acceleration in the mouse: Multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system. Exp Neurol. 2016 Jan;275 Pt 3:436-49. doi: 10.1016/j.expneurol.2014.11.004. Epub 2014 Nov 20.

Ryu J, Horkayne-Szakaly I, Xu L, Pletnikova O, Leri F, Eberhart C, Troncoso JC, Koliatsos VE. The problem of axonal injury in the brains of veterans with histories of blast exposure. Acta Neuropathol Commun. 2014 Nov 25;2:153. doi: 10.1186/s40478-014-0153-3.
Abraham Kupfer, Ph.D. Abraham Kupfer, Ph.D. - Institute for Basic Biomedical Sciences
Professor, Cell Biology

Immunology; CD4 T Cell activation and tolerance; imaging cellular immune interactions
Marikki Laiho, M.D., Ph.D. Marikki Laiho, M.D., Ph.D.
Professor, Radiation Oncology

DNA damage response; cancer biology
Peltonen K, Colis L, Liu H, Trivedi R, Moubarek MS, Moore HM, Bai B, Rudek MA, Bieberich CJ, Laiho, M. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 25(1):77-90, 2014. PMCID: PMC3930145.

Peltonen P, Colis C, Liu H, Jäämaa S, Zhang Z, af Hällström T, Moore HM, Sirajuddin P, Laiho M. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Molecular Cancer Therapeutics 13(11):2537-2546, 2014. PMCID: PMC4221476
Gyanu Lamichhane, Ph.D. Gyanu Lamichhane, Ph.D. - Research Lab
Associate Professor, Medicine

Fundamental biochemical and genetic mechanism in bacterial biology
Kumar P, Kaushik A, Lloyd EP, Li SG, Mattoo R, Perryman AL, Ekins S, Ginell SL, Townsend CA, Freundlich JS, Lamichhane G. New antibacterials targeting non-classical transpeptidases. Nature Chemical Biology. 2017. 13; 54-61. PMID 27820797.

Schoonmaker MK, Bishai WR, Lamichhane G. Non-classical cross-linking of the peptidoglycan of Mycobacterium tuberculosis is required for cell morphology, virulence and resistance to β-lactams and glycopeptides. Journal of Bacteriology. 2014; 196 (7), 1394-402.PMID 24464457
(Ben) Harry B. Larman, Ph.D. Harry (Ben) Larman, Ph.D. - Research Lab
Assistant Professor, Immunopathology

Profiling human immune responses; multiplexed RNA analyses
George J. Xu, Tomasz Kula, Qikai Xu, Mamie Z. Li, Suzanne D. Vernon, Thumbi Ndung', Kiat Ruxrungtham, Jorge Sanchez, Christian Brander, Raymond Chung, Kevin C. O'Connor, Bruce Walker, H. Benjamin Larman, & Stephen J. Elledge, "Comprehensive serological profiling of human populations using a synthetic human virome," Science. 384(6239):aaa0698-1-9, 2015. PMID: 26045439

Joel J. Credle, Christopher Y. Itoh, Tiezheng Yuan, Rajni Sharma, Erick R. Scott, Rachael E. Workman, Yunfan Fan, Franck Housseau, Nicolas J. Llosa, W. Robert Bell, Heather Miller, Sean X. Zhang, Winston Timp and H. Benjamin Larman, "Multiplexed analysis of fixed tissue RNA using Ligation in situ Hybridization", Nucleic Acids Research, June;1-9. 2017. PMID: 28854731
John J. Laterra, M.D., Ph.D. John J. Laterra, M.D., Ph.D.
Professor, Neurology

Brain malignancy, cancer stem cells, oncogenic signaling
Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, Xia S, Trageser D, Guerrero-Cázares H, Eberhart CG, Quiñones Hinojosa A, Scheffler B, Laterra J. c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A. 108:9951-6, 2011. PMID: 21628563. PMCID: PMC3116406.

Lopez-Bertoni H, Lal B, Michelson H, Guerrero-Cázares H, Quiñones-Hinojosa A, Li Y, Laterra J. Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells. Oncogene, 2016 Feb 22. doi: 10.1038/onc.2016.22. [Epub ahead of print].
Anne Le, M.D. Anne Le, M.D. - Research Lab
Associate Professor, Pathology and Oncology

Metabolomics technologies, cancer metabolism and metabolic aspects of other diseases
Amira Elgogary, Qingguo Xu, Brad Poore, Jesse Alt, Sarah C. Zimmermann, Liang Zhao, Jie Fu, Baiwei Chen, Shiyu Xia, Yanfei Liu, Marc Neisser, Christopher Nguyen, Ramon Lee, Joshua K. Park, Juvenal Reyes, Thomas Hartung, Camilo Rojas, Rana Rais, Takashi Tsukamoto, Gregg L. Semenza, Justin Hanes, Barbara S. Slusher, and Anne Le. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. E5328-E5336 | PNAS Published online August 24, 2016

Anne Le, Andrew N. Lane, Max Hamaker, Sminu Bose, Arvin Gouw, Joseph Barbi, Takashi Tsukamoto, Camilio J. Rojas, Barbara S. Slusher, Haixia Zhang, Lisa J. Zimmerman, Daniel C. Liebler, Robbert J.C. Slebos, Pawel K. Lorkiewicz, Richard M. Higashi, Teresa W.M. Fan, and Chi V. Dang. Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells. Cell Metabolism 15, 110-121, January 4, 2012.
Gabsang Lee, Ph.D. Gabsang Lee, Ph.D. - Research Lab
Associate Professor, Neurology and Neuroscience

Neural crest cell biology; Peripheral nerves disease; Congenital Insensitivity of Pain and Anhidrosis; Familial Dysautonomia; Charcot-Marie-Tooth 1A; Skeletal muscle; Duchenne muscular dystrophy; Facioscapulohumeral muscular dystrophy
Oh YH, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C, Lee G. Functional coupling with cardiac muscle promotes maturation of hPSC-derived sympathetic neurons. Cell Stem Cell 2016 PMID: 27320040

Oh Y, Zhang F, Wang Y, Lee EM, Choi IY, Lim H, Mirakhori F, Li R, Huang L, Xu T, Wu H, Li C, Qin C-F, Wen Z, Wu Q-F, Tang H, Xu Z, Jin P, Song H, Ming G-L, Lee G. Zika virus directly infects human peripheral neurons and induces cell death. Nature Neuroscience. 2017 20:1209-1212. PMID: 28758997
Jennifer Lee-Summers, M.D. Jennifer Lee-Summers, M.D.
Associate Professor, Dept. of Anesthesiology and Critical Care Medicine, Division of Pediatric Anesthesia and Critical Care Medicine

Hypothermia; moyamoya; neonatal; cerebrovascular; anesthesia; pediatrics
Thomas E. Lloyd, M.D., Ph.D. Thomas E. Lloyd, M.D., Ph.D.
Associate Professor, Neurology and Neuroscience

Neurodegenerative disorders (ALS, CMT Disease, Inclusion Body Myositis); axonal transport and organelle trafficking in neurons
Machamer JB, Collins SE, Lloyd TE; The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction. Human Molecular Genetics. 2014; 23(14)3810-22.

Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd T*, Rothstein J*; The C9ORF72 repeat expansion disrupts nucleocytoplasmic transport. Article. Nature 2015; 525: 56-61.
Tamara Lotan, M.D. Tamara Lotan, M.D.
Professor, Pathology - Kidney/GU Pathology; Co-Director, Graduate Program in Pathobiology

Role of oncogenic signaling pathways in prostate and mammary epithelial migration and polarity
Tan H, Sood A, Rahimi HA, Wang W, Gupta N, Hicks J, Mosier S, Gocke CD, Epstein JI, Netto GJ, Liu W, Isaacs WB, De Marzo AM, Lotan TL. Rb Loss is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma. Clinical Cancer Research. 2014; 20(4):890-903. PMID: 24323898.

Ahearn TU, Pettersson A, Ebot EM, Gerke T, Graff RE, Morais CL, Hicks JL, Wilson KM, Rider JR, Sesso HD, Fiorentino M, Flavin R, Finn S, Giovannucci EL, Loda M, Stampfer MJ, De Marzo AM, Mucci LA, Lotan TL. A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer. Journal of the National Cancer Institute. 2016; 108(2). PMID: 26615022
Jun Luo, Ph.D. Jun Luo, Ph.D.
Professor, Department of Urology
James Buchanan Brady Urological Institute

Prostate cancer; Androgen receptor splice variants; Sequencing technologies; Liquid biopsies; Specimen and measurement sciences pertaining to molecular diagnosis
Antonarakis ES, Lu C, Luber B, Wang H, Chen Y, Silberstein J, Taylor M, Maughan B, Denmeade SR, Pienta K, Paller C, Carducci MA, Eisenberger MA, Luo J. Clinical significance of AR-V7 mRNA detection in CTCs of men with metastatic castration-resistant prostate cancer treated with first- and second-line abiraterone and enzalutamide. Journal of Clinical Oncology 2017; 35: 2149-2156. PMCID: PMC5493048.

Zhu Y, Sharp A, Anderson CM, Silberstein JL, Taylor M, Lu C, Zhao P, De Marzo AM, Antonarakis ES, Wang M, Wu X, Luo Y, Su N, Nava Rodrigues D, Figueiredo I, Welti J, Park E, Ma XJ, Coleman I, Morrissey C, Plymate SR, Nelson PS, de Bono JS, Luo J. Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer. Eur Urol. 2018;73(5):727-35. Epub 2017/09/04. doi: 10.1016/j.eururo.2017.08.009. PMID: 28866255. PMC in process.
Leo Luznik, M.D. Leo Luznik, M.D.
Professor, Oncology; Division of Hematologic Malignancies

Pathogenesis of GVHD, tolerance induction and immunotherapy
Joseph L. Mankowski, D.V.M., Ph.D. Joseph L. Mankowski, D.V.M., Ph.D.
Professor and Director, Molecular and Comparative Pathobiology

Virology; HIV; pathogenesis of CNS lesions
Knight AC, Brill SA, Queen SE, Tarwater PM, Mankowski JL. Increased Microglial CSF1R Expression in the SIV/Macaque Model of HIV CNS Disease. J Neuropathol Exp Neurol. 2018 Mar 1;77(3):199-206. doi: 10.1093/jnen/nlx115. PMID: 29319809

Mangus LM, Beck SE, Queen SE, Brill SA, Shirk EN, Metcalf Pate KA, Muth DC, Adams RJ, Gama L, Clements JE, Mankowski JL. Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy. Am J Pathol. 2018 Jan;188(1):125-134. doi: 10.1016/j.ajpath.2017.08.035. Epub 2017 Dec 8. PMID: 29229308
Nicholas J. Maragakis, M.D. Nicholas J. Maragakis, M.D.
Professor, Neurology and Neuromuscular Diseases

Stem cell-derived motor neurons and glia; Amyotrophic Lateral Sclerosis (ALS)
Akshata A. Almad, Arpitha Doreswamy, Sarah K. Gross, Jean-Philippe Richard, Yuqing Huo, Norman Haughey, and Nicholas J. Maragakis. Connexin 43 in Astrocytes Contributes to Motor Neuron Toxicity in Amyotrophic Lateral Sclerosis. GLIA 2016;64:1154-1169.

Amanda M. Haidet-Phillips, Laurent Roybon, Sarah K. Gross, Alisha Tuteja, Christopher J. Donnelly, Jean-Philippe Richard, Myungsung Ko, Alex Sherman, Kevin Eggan, Christopher E. Henderson, Nicholas J., Maragakis. Gene Profiling of Human Induced Pluripotent Stem Cell-Derived Astrocyte Progenitors Following Spinal Cord Engraftment. Stem Cells Translational Medicine 2014;3:1-12.
Lee J. Martin, Ph.D. Lee J. Martin, Ph.D.
Professor, Pathology - Neuropathology
Program Director, Graduate Program in Pathobiology

Cell death; motor neuron diseases; Parkinson's disease
Alan K. Meeker, Ph.D. Alan K. Meeker, Ph.D.
Assistant Professor, Pathology - Kidney/GU Pathology

Cancer biology; telomeres
Mollie K. Meffert, M.D., Ph.D. Mollie K. Meffert, M.D., Ph.D.
Associate Professor, Biological Chemistry and Neuroscience

Gene expression; neuronal plasticity; learning and memory; cognitive dysfunction
Stephen J. Meltzer, M.D. Stephen J. Meltzer, M.D.
Professor, Gastroenterology

Barrett's esophagus; esophageal carcinoma
Xie J-J, Jiang Y-Y, Xu L-Y, Li C-Q, Fullwood M, Chee L-M, Ann O, Yang H, Mayakonda A, Ding L-W, Long L, Sun C, Lin L-H, Wu J-Y, Wu Z-Y, Cao Q, Fant W-K, Li E-M, Meltzer SJ, Lin D-C, Koeffler HP. Increased expression of the long non-coding RNA LINC01503, regulated by TP63, in squamous cell carcinoma and effects on oncogenic activities of cancer cell lines. Gastroenterol. 2018 Feb 15. Pii: S0016-5085(18)3023-0. Doi:10. 1053/j.gastro.2018.02.018 [Epub]. PMID: 29454790

Ke X, Yan R, Sun Z, Cheng Y, Meltzer A, Lu NH, Shu X, Wang Z, Huang B, Liu X, Wang Z, Song JH, Ibrahim S, Abraham JM, Shin EJ, He S, Meltzer SJ. Esophageal adenocarcinoma-derived extracellular vesicle microRNAs induce a neoplastic phenotype in benign gastric organoids. Neoplasia 2017 Sep 29;19(11):941-949. Doi: 10.1016/j.neo.2017.06.007 [Epub]. PMID: 28968550.
Lloyd S. Miller, M.D., Ph.D. Lloyd S. Miller, M.D., Ph.D.
Vice Chair for Research, Dermatology; Professor, Departments of Dermatology; Medicine, Division of Infectious Diseases; Orthopaedic Surgery

Staphylococcus aureus infections, cutaneous host defense, skin microbiome, inflammatory skin diseases and biofilm-related infections
Liu, H, Archer, NK, Dillen, CA, Wang, Y, Ashbaugh, AG, Ortines, RV, Kao, T, Lee, SK, Cai, SS, Miller, RJ, Marchitto, MC, Zhang, E, Riggins, DP, Plaut, RD, Stibitz, S, Geha, RS, Miller, LS. 2017. Staphylococcus aureus epicutaneous exposure drives skin inflammation via IL-36-mediated T cell responses. Cell Host Microbe 22: 653ÔÇô666. PMCID: PMC5774218.

Dillen CA, Pinsker BL, Marusina AI, Merleev AA, Farber ON, Liu H, Archer NK, Lee DB, Wang Y, Ortines RV, Lee SK, Marchitto MC, Cai SS, Ashbaugh AG, May LS, Holland SK, Freeman AF, Miller LG, Yeaman MR, Simon SI, Milner JD, Maverakis E, Miller LS. 2018. Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection. J Clin Invest 128(3):1026-1042. PMCID: PMC5824877.
Guo-li Ming, M.D., Ph.D. Guo-li Ming, M.D., Ph.D.
Professor of Neurology and Neuroscience, Institute for Cell Engineering

Neuronal navigation - fetal and adult; neurological diseases and mental disorders
Zhexing Wen, Ha Nam Nguyen, Ziyuan Guo4, Matthew A. Lalli, Xinyuan Wang, Yijing Su, Nam-Shik Kim, Ki-Jun Yoon, Jaehoon Shin, Ce Zhang, Georgia Makri, David Nauen, Huimei Yu, Elmer Guzman, Cheng-Hsuan Chiang, Nadine Yoritomo, Kozo Kaibuchi, Jizhong Zou, Kimberly M. Christian, Linzhao Cheng, Christopher A. Ross, Russell L. Margolis, Gong Chen, Kenneth S. Kosik, Hongjun Song & Guo-li Ming. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature 515, 414-418(20 November 2014) doi:10.1038/nature13716. Received 23 February 2014; Accepted 28 July 2014; Published online 17 August 2014.

Xuyu Qian, Ha Nam Nguyen, Mingxi M. Song, Hengli Tang, Hongjun Song, Guo-li Ming. Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Qian et al., 2016, Cell 165, 1-17; May 19, 2016: 2016 Elsevier Inc. (
Monica R. Mugnier, Ph.D. Monica R. Mugnier, Ph.D.
Assistant Professor, Dept. of Molecular Microbiology and Immunology

Antigenetic variation; T. brucel; kinetoplastid; host-pathogen interactions; bioniformatics; genomics
Monica R. Mugnier, George A. M. Cross, F. Nina Papavasiliou. (2015) The in vivo dynamics of antigenic variation in Trypansoma brucei. Science. 347(6229): 1470-1473.

Monica R. Mugnier, C. Erec Stebbins, and F. Nina Papavasiliou. (2016) Masters of Disguise: Antigenic variation and the VSG coat in Trypanosoma brucei. PLOS Pathogens. 12(9): e1005784.
Eric Nuermberger, M.D. Eric Nuermberger, M.D.
Professor of Medicine, Division of Infectious Diseases; Professor, Department of International Health, JHSPH

Experimental chemotherapy of TB and pneumonia caused by Streptococcus pneumoniae
Drew M. Pardoll, M.D., Ph.D. Drew M. Pardoll, M.D., Ph.D.
Professor, Oncology; Medicine; Molecular Biology and Genetics; Pathology

Gene and cell therapy
Ben Ho Park, M.D., Ph.D. Ben Ho Park, M.D., Ph.D.
Professor, Oncology

Breast cancer genetics
Chu D, Paoletti C, Gersch C, VanDenBerg DA, Zabransky DJ, Cochran RL, Wong HY, Toro PV, Cidado J, Croessmann S, Erlanger B, Cravero K, Kyker-Snowman K, Button B, Parsons H, Dalton BD, Gillani R, Medford A, Aung K, Tokudome N, Chinnaiyan A, Schott A, Robertson D, Jacks KS, Lauring J, Hurley P, Hayes DF, Rae JM and Park BH. A high frequency of ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients. Clinical Cancer Research, Feb 15;22(4):993-9, 2016 (in press 2015).

Beaver JA, Jelovac D, Balukrishna S, Cochran R, Croessmann S, Zabransky DJ, Wong HY, Toro PV, Cidado J, Blair BG, Chu D, Burns T, Higgins MJ, Stearns V, Jacobs L, Habibi M, Lange J, Hurley PJ, Lauring J, VanDenBerg D, Kessler J, Jeter S, Samuels M, Maar D, Cope L, Cimino-Mathews A, Argani P, Wolff AC* and Park BH*. Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer, Clinical Cancer Research, May 15;20(10):2643-50, 2014, *co-corresponding senior authors.
Jonathan Pevsner, Ph.D. Jonathan Pevsner, Ph.D.
Professor, Neuroscience

Bioinformatics; neuropathology
Kenneth J. Pienta, M.D. Kenneth J. Pienta, M.D.
Donald S. Coffey Professor of Urology; Director, Urology Research Laboratories; Professor, Urology; Oncology; Pharmacology and Molecular Sciences; and Chemical and Biomolecular Engineering

Oncology; Prostate Cancer
Amend SR, Roy S, Brown JS, Pienta KJ. Ecological paradigms to understand the dynamics of metastasis. Cancer Lett. 2015 Oct 10. PMID: 26458994.

Amend SR, Pienta KJ. Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype. Oncotarget. 2015;6(12):9669-78. PMID: 25895024.
Martin G. Pomper, M.D., Ph.D. Martin G. Pomper, M.D., Ph.D.
William R. Brody Professor of Radiology

Molecular imaging research; development of new radiotracers for PET and SPECT
Hyo-eun C Bhang, Kathleen L Gabrielson, John Laterra, Paul B Fisher & Martin G Pomper. Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression. Nature Medicine, Vol 17, No. 1, 123-130, Jan 2011.

Jennifer M. Coughlin, MD; YuchuanWang, PhD; Il Minn, PhD; Nicholas Bienko, MS; Emily B. Ambinder, MD; Xin Xu, MS; Matthew E. Peters, MD; JohnW. Dougherty, DO; Melin Vranesic, MD; Soo Min Koo, BS; Hye-Hyun Ahn, PhD; Merton Lee, PhD; Chris Cottrell, BS; Haris I. Sair, MD; Akira Sawa, MD, PhD; Cynthia A. Munro, PhD; Christopher J. Nowinski, AB; Robert F. Dannals, PhD; Constantine G. Lyketsos, MD; Michael Kassiou, PhD; Gwenn Smith, PhD; Brian Caffo, PhD; Susumu Mori, PhD; Tomas R. Guilarte, PhD; Martin G. Pomper, MD, PhD. Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players. JAMA Neurol. doi:10.1001, E1-E8, jamaneurol.2016.3764. Published online November 28, 2016.

Sangeeta R. Banerjee, Catherine A. Foss, Allen Horhota, Mrudula Pullambhatla, Kevin McDonnell, Stephen Zale, and Martin G. Pomper. In- and IRDye800CW-Labled PLA-PEG Nanoparticle for Imaging Prostate-Specific Membrane Antigen-Expressing Tissues. BioMacromolecules, 2017, 18, 201-209.
Jonathan Powell, M.D., Ph.D. Jonathan Powell, M.D., Ph.D.
Professor, Oncology

Cancer, Immunology; hematopoiesis
Eric H. Raabe, M.D., Ph.D. Eric H. Raabe, M.D., Ph.D.
Associate Professor, SOM Oncology; Pediatric Oncology

Targeting stem cell factors and their downstream effectors in malignancy
Harpreet Kaur, Sabeen Zulfiqar Ali, Lauren Huey, Marianne Hütt-Cabezas, Isabella Taylor, Xing-gang Mao, Melanie Weingart, Qian Chu, Fausto J. Rodriguez, Charles G. Eberhart, Eric H. Raabe. The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma. H. Kaur et al. / Cancer Letters 377 (2016) 55-64.

Allison R. Hanaford, Tenley C. Archer, Antoinette Price, Ulf D. Kahlert, Jarek Maciac- zyk, Guido Nikkhah, Jong Wook Kim, Tobias Ehrenberger, Paul A. Clemons, Vlado Dancik, Brinton Seashore-Ludlow, Vasanthi Viswanathan, Michelle L. Stewart, Matthew G. Rees, Alykhan Shamji, Stuart Schreiber, Ernest Fraenkel, Scott L. Pomeroy, Jill P. Mesirov, Pablo Tamayo, Charles G. Eberhart, and Eric H. Raabe. DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. Clin Cancer Res; 2016:OF1-OF12.
Linda M. Resar, M.D. Linda M. Resar, M.D.
Professor, Medicine - Hematology

HMGA chromatin remodeling proteins in cancer and stem cell biology
Yanagisawa B & Resar LMS. Hitting the bull's eye: Targeting HMGA1 in cancer stem cells. Expert Review of Anticancer Therapy 2014; 14:23-30.

Xian L, Georgess D, Huso T, Cope LM, Belton A, Chang Y-T, Kuang W, Gu Q, Zhang X, Senger S, Fasano A, Huso DL, Ewald AJ, Resar LMS. Hmga1 amplifies Wnt Signaling and expands the intestinal stem cell compartment and Paneth cell niche. Nature Comm 2017; in press.
Gregory J. Riggins, M.D., Ph.D. Gregory J. Riggins, M.D., Ph.D.
Neurology and Neurosurgery
Professor, Neurological Surgery

Neuro-oncology; molecular targets; genomics
Nicholas Roberts, Vet.M.B., Ph.D. Nicholas Roberts, Vet.M.B., Ph.D.
Assistant Professor, Pathology

Pancreatic cancer susceptibility gene defects
Skaro M, Nanda N, Gauthier C, Felsenstein M, Jiang Z, Qiu M, Shindo K, Yu J, Hutchings D, Javed AA, Beckman R, He J, Wolfgang CL, Thompson E, Hruban RH, Klein AP, Goggins M, Wood LD, Roberts NJ. Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms. Gastroenterology. 2019 May;156(6):1905-1913. doi: 10.1053/j.gastro. 2019.01.254. Epub 2019 Feb 1.

Roberts NJ, Norris AL, Petersen GM, Bondy ML, Brand R, Gallinger S, Kurtz RC, Olson SH, Rustgi AK, Schwartz AG, Stoffel E, Syngal S, Zogopoulos G, Ali SZ, Axilbund J, Chaffee KG, Chen YC, Cote ML, Childs EJ, Douville C, Goes FS, Herman JM, Iacobuzio-Donahue C, Kramer M, Makohon-Moore A, McCombie RW, McMahon KW, Niknafs N, Parla J, Pirooznia M, Potash JB, Rhim AD, Smith AL13, Wang Y, Wolfgang CL, Wood LD, Zandi PP, Goggins M, Karchin R, Eshleman JR, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH, Klein AP. Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. Cancer Discov. 2016 Feb;6(2):166-75. doi: 10.1158/2159-8290.CD-15-0402. Epub 2015 Dec 9.
Richard S. Roden, Ph.D. Richard S. Roden, Ph.D.
Professor, Pathology - GYN Pathology

Cancer/virology; HPV in cervical cancer
Wang JW, Jiang R, Peng S, Chang YN, Hung CF, Roden RB. Immunologic Control of Mus musculus Papillomavirus Type 1. PLoS Pathog. 2015 Oct 23;11(10):e1005243. doi: 10.1371/journal.ppat. 1005243. eCollection 2015 Oct. PMID:26495972.

Anchoori RK, Karanam B, Peng S, Wang JW, Jiang R, Tanno T, Orlowski RZ, Matsui W, Zhao M, Rudek MA, Hung CF, Chen X, Walters KJ, Roden RB. A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell. 2013 Dec 9;24(6):791-805. doi: 10.1016/j.ccr.2013.11.001. PMID:24332045.
Scheherazade Sadegh-Nasseri, Ph.D. Scheherazade Sadegh-Nasseri, Ph.D.
Professor, Pathology - Immunopathology

Molecular mechanisms in antigen processing and presentation and T cell recognition; Mechanisms in autoimmunity
AeRyon Kim, Tatiana Boronina, , Cole, Robert N, Erika Darrah, and Scheherazade Sadegh-Nasseri. Distorted Immunodominance by Linker Sequences or other Epitopes from a Second Protein Antigen During Antigen-Processing. Scientific Reports. 2017 Apr 19;7:46418. doi: 10.1038/srep46418. PMID: 28422163

AeRyon Kim, Isamu Z. Hartman,W, Brad Poore, Tatiana Boronina, Robert N. Cole, Nianbin Song, M. Teresa Ciudad, Rachel R. Caspi, Dolores Jaraquemada & Scheherazade Sadegh-Nasseri. Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources. Nature Communications; 5:5369; DOI: 10.1038; ncomms6369.
Jonathan P. Schneck, M.D., Ph.D. Jonathan P. Schneck, M.D., Ph.D. - Research Lab
Professor, Pathology - Immunopathology

Immunology; T cell activation
Kosmides AK, Sidhom JW, Fraser A, Bessell CA, Schneck JP. Dual Targeting Nanoparticle Stimulates the Immune System to Inhibit Tumor Growth. ACS Nano. 2017 Jun 27; 11(6):5417-5429. doi: 10.1021/acsnano.6b08152. Epub 2017 Jun

Perica K, Bieler JG, Schütz C, Varela JC, Douglass J, Skora A, Chiu YL, Oelke M, Kinzler K, Zhou S, Vogelstein B, Schneck JP. Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy. ACS Nano. 2015 Jul 28; 9(7):6861-71. doi: 10.1021/acsnano.5b02829. Epub 2015 Jul 14

Mathias Oelke, Marcela V. Maus, Dominic Didiano, Carl H. June, Andreas Mackensen & Jonathan P. Schneck. Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells. Nature Medicine 9, 619-625 (2003). doi:10.1038/nm869. Epub 2003 Apr 21
Cynthia L. Sears, M.D. Cynthia L. Sears, M.D.
Professor of Medicine, Oncology, and Molecular Micobiology & Immunology

Enteric pathogens; colon cancer; bacteroides fragilis
Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu1 X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, and Sears CL. Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria. Science 2018 Feb 02; 359: 6375: 592-597.

Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister FM, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL*, and Housseau F*. Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe. 2018 March 14; 23(3): 421. *co-senior authors
Gregg L. Semenza, M.D., Ph.D. Gregg L. Semenza, M.D., Ph.D. - Research Lab
C. Michael Armstrong Professor of Genetic Medicine, Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry; Director, Vascular Program, Institute for Cell Engineering

Role of hypoxia-inducible factors in breast cancer metastasis, cancer stem cell specification, and immune evasion; development of HIF inhibitors for cancer therapy
Lu H, Tran L, Park Y, Chen I, Lan J, Xie Y, Semenza GL. Reciprocal regulation of DUSP9 and DUSP16 expression by HIF-1 controls ERK and p38 MAP kinase activity and mediates chemotherapy-induced breast cancer stem cell enrichment. Cancer Res 78(15):4191-4202 (2018). PMID:29880481.

Samanta D, Park Y, Ni X, Li H, Zahnow CA, Gabrielson E, Pan F, Semenza GL. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proc Natl Acad Sci USA 115(6):E1239-E1248 (2018). PMID: 29367423.
Karen Sfanos, M.S., Ph.D. Karen Sfanos, M.S., Ph.D. - Research Lab
Professor, Pathology - Kidney/GU Pathology

Kidney urologic pathology
Sfanos, K.S.*, Aloia, A.L., Hicks, J.L., Esopi, D.M., Steranka, J.P., Shao, W., Sanchez-Martinez, S., Yegnasubramanian, S., Burns, K.H., Rein, A., De Marzo, A.M. Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines. PLoS ONE. 2011; 6(6): e20874. *corresponding author

Sfanos, K.S.*, Canene-Adams, K., Hempel, H., Yu, S.-H., Simons, B.W., Schaeffer, A.J., Schaeffer, E.M., Nelson, W.G., De Marzo, A.M. Bacterial prostatitis enhances 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced cancer at multiple sites. Cancer Prevention Research, 8:683-692, 2015. *corresponding author
Dipali Sharma, Ph.D. Dipali Sharma, Ph.D.
Professor, Oncology

Breast cancer
Nagalingam, A., Kuppusamy, P., Singh, S. V., Sharma, D and Saxena, N. K. Mechanistic elucidation of the antitumor properties of Withaferin A in breast cancer. Cancer Research, 74(9):2617-29, 2014.

Avtanski, D. B., Nagalingam, A., Kuppusamy, P., Bonner, M. Y., Arbiser, J. L., Saxena, N. K., and Sharma, D. Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner. Oncotarget, 6(18):16396-410, 2015.
Ie-Ming Shih, M.D., Ph.D. Ie-Ming Shih, M.D., Ph.D. - Research Lab; Shih Photography
Richard W. TeLinde Distinguished Professor, Department of Gynecology and Obstetrics; Co-director, the Breast and Ovarian Cancer Program, Johns Hopkins Cancer Center

Initiation, dormancy and evolution in cancer
Angeleso M, Papdopoulos N, Ayhan A, Wang TL, Nazeran TM, Horlings HM, Noe M, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu RC, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Wang Y, Cohen, J, Wong F, Hasanovic A, Orr, Wang M, Popoli M, McMahon W, Wood L, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks B, Diza L, Wang TL, Vogelstein B, Yong PJ, Huntsman DG, Shih IM. Cancer associated mutations in endometriosis without cancer. N Engl J Med, 376:1835-1848, 2017. PMID: 28489996

Yu Y, Gaillard S, Jude MP, Huang TC, Pinto SM, Tessarollo NG, Zhang Z, Pandey A, Wirtz D, Ayhan A, Davidson B, Wang TL, Shih IM. Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell, 28:82-96, 2015. PMID: 26096845
Debasish Sinha, Ph.D. Debasish Sinha, Ph.D.
Associate Professor, Ophthalmology School of Medicine

Glial cell function; autophagy and phagocytosis in retinal pigmented epithelial cells
Mallika Valapala, Christine Wilson, Stacey Hose, Imran A Bhutto, Rhonda Grebe, Aling Dong, Seth Greenbaum, Limin Gu, Samhita Sengupta, Marisol Cano, Sean Hackett, Guotong Xu, Gerard A Lutty, Lijin Dong, Yuri Sergeev, James T Handa, Peter Campochiaro, Eric Wawrousek, J Samuel Zigler, Jr, and Debasish Sinha. Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling. Autophagy 10:3, 480-496; March 2014; © 2014 Landes Bioscience.

Mallika Valapala, Stacey Hose, Celine Gongora, Lijin Dong, Eric F. Wawrousek, J. Samuel Zigler Jr & Debasish Sinha. Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes. Nature Communications. Received 18 Jul 2012; Accepted 20 Feb 2013; Published 27 Mar 2013. DOI: 10.1038/ncomms2624.
Shan Sockanathan, Ph.D. Shan Sockanathan, Ph.D. - Research Lab
Professor, Neuroscience

Motor neuron signaling; retinoid signals; neurodegeneration
Park, S., Lee, C., Sabharwal, P., Zhang, M., Freel Meyers, C., and Sockanathan S. (2013) GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science 339, 324-328. (PMCID: PMC3644959)

Yan, Y, Wldayka, C., Fujii, J., and Sockanathan, S. (2015) Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nature Comm. 6; 6:7006.
Hongjun Song, Ph.D. Hongjun Song, Ph.D.
Professor, Neurology and Neuroscience; Director, Stem Cell Program - ICE

Adult mammalian neural stem cells and neurogenesis; neuroepigenetics; mechanisms of neurological diseases and mental disorders
Shin, J., Berg, D.A., Zhu, Y., Shin, J.Y., Song, J., Bonaguidi, M.A., Enikolopov, G., Nauen, D.W., Christian, K.M., Ming, G-l., and Song, H. (2015). Single-cell RNA-seq with Waterfall reveals molecular cascades underlying adult neurogenesis. Cell Stem Cell 17, 360-72.

Yu, H., Su, Y., Shin, J., Zhong, C., Guo, J.U., Weng, Y-l., Gao, F., Geschwind, D.H., Coppola, G., Ming, G-l., and Song, H. (2015). Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature Neuroscience 18, 836-843.
Charles J. Steenbergen, M.D., Ph.D. Charles J. Steenbergen, M.D., Ph.D.
Professor, Pathology - Cardiac Pathology

Cardiac Pathology; ischemia reperfusion Injury; cardioprotective signaling mechanisms
Saraswati Sukumar, Ph.D. Saraswati Sukumar, Ph.D.
Professor, Oncology

Breast cancer; Hox genes; methylated genes as biomarkers and targets of therapy; genome-wide analysis; intraductal therapy of early lesions
Mary Jo Fackler, Zoila Lopez Bujanda, Christopher Umbricht, Wei Wen Teo, Soonweng Cho, Zhe Zhang, Kala Visvanathan, Stacie Jeter, Pedram Argani, Chenguang Wang, Jaclyn P. Lyman, Marina de Brot, James N. Ingle, Judy Boughey, Kandace McGuire, Tari A. King, Lisa A. Carey, Leslie Cope, Antonio C. Wolff, and Saraswati Sukumar. Novel Methylated Biomarkers and a Robust Assay to Detect Circulating Tumor DNA in Metastatic Breast Cancer Cancer Res; 74(8) April 15, 2014, 2160-2170.

Kideok Jin, Sunju Park, Wei Wen Teo, Preethi Korangath, Sean Soonweng Cho, Takahiro Yoshida, Balázs Gyõrffy, Chirayu Pankaj Goswami, Harikrishna Nakshatri, Leigh-Ann Cruz, Weiqiang Zhou, Hongkai Ji, Ying Su, Muhammad Ekram, Zhengsheng Wu, Tao Zhu, Kornelia Polyak, and Saraswati Sukumar. HOXB7 Is an ERa Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance. July 15, 2015; DOI: 10.1158/2159-8290.CD-15-0090
Charlotte J. Sumner, M.D. Charlotte J. Sumner, M.D.
Professor, Neurology & Neuroscience

Inherited motor neuron and peripheral nerve diseases; Genetic characterization; Cellular mechanisms, and novel therapies
Shuying Sun, Ph.D. Shuying Sun, Ph.D. - Research Lab
Assistant Professor, Neuropathology, Brain Science Institute

ALS; Neurodegeneration; RNA processing pathways; CRISPR screen; Therapy development
Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW. (2015) ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nature Communications 6: 6171.

Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, and Cleveland DW. (2015) Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A. 112(50): E6993-7002.
Aaron A. Tobian, M.D., Ph.D. Aaron A. Tobian, M.D., Ph.D.
Professor, Pathology - Transfusion Medicine; Epidemiology

Biological mechanisms of allergic transfusion reactions, epidemiologic risk factors of HIV
Grabowski MK, Gray RH, Makumbi F, Kagaayi J, Redd AD, Kigozi G, Reynolds SJ, Nalugoda F, Lutalo T, Wawer MJ, Serwadda D, Quinn TC, Tobian AAR. Use of injectable hormonal contraception and womens risk for herpes simplex virus type 2 acquisition: a prospective study of couples in Rakai, Uganda. Lancet Global Health. 2015; 3:e478-86.

Redd AD, Quinn TC, and Tobian AAR. Frequency and implications of HIV superinfection. Lancet Infectious Diseases. 2013; 13: 622-628.
Juan C. Troncoso, M.D. Juan C. Troncoso, M.D.
Professor, Pathology - Neuropathology

Neuropathology; Stroke
Christopher B. Umbricht, M.D., Ph.D. Christopher B. Umbricht, M.D., Ph.D.
Associate Professor, Surgery

Breast cancer; Thyroid cancer; Early cancer progression; Genome-wide analyses; Bioinformatics
Kim HS, Umbricht CB, Illei PB, Cimino-Mathews A, Cho S, Chowdhury N, Figueroa-Magalhaes MC, Pesce C, Jeter SC, Mylander C, et al. Optimizing the Use of Gene Expression Profiling in Early-Stage Breast Cancer. J Clin Oncol. 2016 Dec 20;34(36):4390-4397. PubMed PMID: 27998227.

Avin BA, Umbricht CB, Zeiger MA. Human telomerase reverse transcriptase regulation by DNA methylation, transcription factor binding and alternative splicing (Review). Int J Oncol. 2016 Dec;49(6):2199-2205. PubMed PMID: 27779655.
Raphael P. Viscidi, M.D. Raphael P. Viscidi, M.D.
Professor, Pediatrics

Virology/Immunology; Human papillomaviruses/Polyomaviruses and vaccine development
Beck SE, Queen SE, Viscidi R, Johnson D, Kent SJ, Adams RJ, Tarwater PM, Mankowski JL. Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control. J Neurovirol. 2016 Aug;22(4):498-507. PMID: 26727909.

Rossi F, Li X, Jacobson L, Levine AJ, Chen Y, Palella FJ, Margolick J, Viscidi R. BK virus capsid antibodies are associated with protection against subsequent development of PML in HIV-infected patients. Virology. 2015 Nov;485:467-72. PMID: 26356797.
Mei Wan, Ph.D. Mei Wan, Ph.D.
Professor, Orthopaedic Surgery

Mesenchymal stem cell biology; Tissue and bone remodeling
Li C, Zhen G, Xie L, Crane JL, Farber E, Farber CR, Gao P, Cao X, and Wan M. RhoA Determines Lineage Fate of MSCs by Modulating CTGF-VEGF Complex in Extracellular Matrix. Nature Communications 2016; 7: 11455. PMID: 27126736

Li C, Xing Q, Yu B, Xie H, Wang W, Shi C, Crane JL, Cao X, and Wan M. Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Mineral Res 2013; 28: 2094-108. PMID: 23609180
Jiou Wang, M.D., Ph.D. Jiou Wang, M.D., Ph.D.
Associate Professor, Biochemistry and Molecular Biology, BSPH; Neuroscience, SOM

Neurodegeneration; ALS; Protein folding and misfolding
Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC5, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 2014 Mar 13;507(7491):195-200. doi: 10.1038/nature13124. Epub 2014 Mar 5.

Zhang T, Wu Y, Mullane P, Ji Y, Liu H, He L, Arora A, Hwang H, Alessi A, Niaki A,Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim J, Shorter J, Ong S, Leung A, Wang J. (2018) FUS Regulates Activity of MicroRNA-mediated Gene Silencing. Molecular Cell 69:787-801.
Tian-Li Wang, Ph.D. Tian-Li Wang, Ph.D. - Research Lab
Professor of Pathology, Gynecology & Obstetrics

Cancer genetics; Female reproductive cancer; Notch signaling; Early detection of cancer
Jung JG, Shih IM, Park JT, Gerry E, Kim TH, Ayhan A, Handschuh K, Davidson B, Nickles Fader A, Selleri L, Wang TL. Ovarian cancer chemoresistance relies on the the stem cell reprogramming factor PBX1. Cancer Res. 2016 Sep 2. pii: canres.0980.2016. [Epub ahead of print]

Jung JG, Stoeck A, Guan B, Wu RC, Zhu H, Blackshaw S, Shih IeM, Wang TL. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. PLoS Genet. 2014 Oct 30;10(10):e1004751. doi: 10.1371/journal.pgen.1004751. eCollection 2014.
Philip C-Y Wong, Ph.D. Philip C-Y Wong, Ph.D.
Professor, Pathology - Neuropathology

Neuropathology; neurodegenerative disease
Ling JP, Pletnikova O, Troncoso J and Wong PC. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science 349:650-655, 2015.

Li T, Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C and Wong PC. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature Communications, DOI: 10.1038/ncomms 12082, July 2016.
Laura D. Wood, M.D., Ph.D. Laura D. Wood, M.D., Ph.D. - Research Lab
Associate Professor, GI/Liver Pathology

Transition from non-invasive precursor lesions to invasive cancer; intratumoral heterogeneity
Dal Molin M, Zhang M, de Wilde RF, Ottenhof NA, Rezaee N, Wolfgang CL, Blackford AL, Vogelstein B, Kinzler KW, Papadopoulos N, Hruban RH, Maitra A, Wood LD. Very long-term survival following resection for pancreatic cancer is not explained by commonly mutated genes: results of whole-exome sequencing analysis. Clin Cancer Res. 2015 Apr 15; 21(8):1944-50.

Pea A, Yu J, Rezaee N, Luchini C, He J, Dal Molin M, Griffin JF, Fedor H, Fesharakizadeh S, Salvia R, Weiss MJ, Bassi C, Cameron JL, Zheng L, Scarpa A, Hruban RH, Lennon AM, Goggins M, Wolfgang CL, Wood LD. Targeted DNA sequencing reveals patterns of local progression in the pancreatic remnant following resection of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Ann Surg. 2016 Jul 18. Epub ahead of print
Tzyy-Choou (T-C) Wu, M.D., M.P.H., Ph.D. Tzyy-Choou (T-C) Wu, M.D., M.P.H., Ph.D. - Research Lab
Professor, Pathology - GYN Pathology

Immunology of cancer; Cervical cancer vaccines; HPV
YY Sun, S Peng, L Han, J Qiu, L Song, YC Tsai, B Yang, RB Roden, CL Trimble, CF Hung, TC Wu (2016). Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T Cell Mediated Tumor Control in the Genital Tract. Clinical Cancer Research 22(3):657-69.

T.H. Kang, CP Mao, SY Lee, A Chen, JH Lee, TW Kim, R Alvarez, RB Roden, D Pardoll, CF Hung, T.-C. Wu (2013). Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity. Cancer Research. 73(8);2493-2504.
Srinvasan (Vasan) Yegnasubramanian, M.D., Ph.D. Srinvasan (Vasan) Yegnasubramanian, M.D., Ph.D.
Associate Professor, Oncology; Pathology;Radiation Oncology

Cancer genetics/epigenetics, AR signaling; genomic instability
Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, Haffner MC, Esopi D, Irizarry RA, Getzenberg RH, Nelson WG, Luo J, Xu J, Isaacs WB, Bova GS, Yegnasubramanian S. DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Sci Transl Med. 2013 Jan 23;5(169):169ra10.

Haffner MC, Esopi DM, Chaux A, Gürel M, Ghosh S, Vaghasia AM, Tsai H, Kim K, Castagna N, Lam H, Hicks J, Wyhs N, Biswal Shinohara D, Hurley PJ, Simons BW, Schaeffer EM, Lotan TL, Isaacs WB, Netto GJ, De Marzo AM, Nelson WG, An SS, Yegnasubramanian S. AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination. Nat Commun. 2017 Jul 26;8(1):142.
Jelani C. Zarif, M.S., Ph.D. Jelani C. Zarif, M.S., Ph.D.
Assistant Professor, Oncology

Cancer immunology and immunotherapy
Zarif, JC, Baena-Del Valle, JA, Hicks, JL, Heaphy, CM, Vidal, I, Luo, J, Lotan, TL, Hooper, JE, Isaacs, WB, Pienta, KJ, De Marzo, AM. Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease European Urology Oncology (In Press)
Hui Zhang, Ph.D. Hui Zhang, Ph.D. - Research Lab
Professor, Pathology - Clinical Chemistry

Structural and functional analyses of proteins and multiple protein modifications by glycosylation, phosphorylation and acetylation
Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou J, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha S-W, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Choi C, Monroe ME, Thomas S, Moore RJ, ,Yu K-H, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih I-M, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD, and the CPTAC investigators. Deep proteogenomic characterization of human ovarian cancer. Cell. 2016; 166: 755-765.

Sun S, Shah P, Toghi Eshghi S, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti NU, Zhang Z, Chan DW, Zhang H. Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nature Biotechnology. 2016; 34: 84-88.

Back to top

Teaching Faculty
Pedram Argani, M.D.
Professor, Surgical Pathology
Walter E. Kaufmann, M.D.
Professor, Neurology
Peter Burger, M.D.
Professor, Surgical Pathology
Thomas Kickler, M.D.
Professor, Hematologic Pathology
Barbara Detrick, Ph.D.
Professor, Immunopathology
Mary S. Leffell, Ph.D., Diplomate, ABHI, ABMLI
Professor, Medical Genetics
Ralph H. Hruban, M.D.
Baxley Professor and Director, Dept. of Pathology; Professor, GI/Liver Oncology
Alexandra Valsamakis, M.D., Ph.D.
Associate Professor, Pathology, Medical Microbiology