Gallbladder and Bile Duct Cancer

2011 News Archive

Mimicker of Gallbladder Adenocarcinoma Described at Johns Hopkins

In recent study, Dr. Aatur Singhi at Hopkins described 6 cases of proliferations of Luschka ducts which were confused with adenocarcinoma of the gallbladder. In fact, in 2 of the cases, the diagnosis of adenocarcinoma had been rendered by the contributing pathologist. Dr. Singhi�s manuscript describes how these developmental variants can undergo proliferation in the setting of cholecystitis, and in the setting of a thickened gallbladder mimic cancer both clinically and pathologically. Dr. Singhi outlines specific criteria to help make this important distinction, and prevent a misdiagnosis of adenocarcinoma which would result in significant over treatment and patient morbidity. These cases illustrate the utility of second opinion pathology in the biliary tract.

American Journal of Surgical Pathology 2011; 35:883-890.

~ December 2011