Gallbladder and Bile Duct Cancer

2011 News Archive

Mimicker of Gallbladder Adenocarcinoma Described at Johns Hopkins

In recent study, Dr. Aatur Singhi at Hopkins described 6 cases of proliferations of Luschka ducts which were confused with adenocarcinoma of the gallbladder. In fact, in 2 of the cases, the diagnosis of adenocarcinoma had been rendered by the contributing pathologist. Dr. Singhi�s manuscript describes how these developmental variants can undergo proliferation in the setting of cholecystitis, and in the setting of a thickened gallbladder mimic cancer both clinically and pathologically. Dr. Singhi outlines specific criteria to help make this important distinction, and prevent a misdiagnosis of adenocarcinoma which would result in significant over treatment and patient morbidity. These cases illustrate the utility of second opinion pathology in the biliary tract.

Reference:
American Journal of Surgical Pathology 2011; 35:883-890.

~ December 2011