Le Cancer Metabolism Research Laboratory


Support our Cancer Metabolism Research

Johns Hopkins University is a 501(c)3, non-profit organization. Any gift to our Institution is tax deductible and can be made payable to "The Johns Hopkins Department of Pathology" and mail to:

Cancer Metabolism Research Fund—Dr. Anne Le
c/o Robert Kahl
Department of Pathology
Johns Hopkins Medicine
600 N. Wolfe Street, Carnegie 424
Baltimore, MD 21287-6417

Credit Card Donations: To donate by credit card online, please click here. The Johns Hopkins Pathology Online Giving Form may open in a new browser window. This is a secure site where all donations to the Department of Pathology at Johns Hopkins are collected.

If you have any questions about how you can help support our work at Johns Hopkins, please contact our development office at 443-287-7947.

Why Support the Research on Cancer Metabolism?

There are currently at least 13 million people in the U.S. who suffer from cancer with 1.5 million additional people diagnosed with cancer each year. Cancer accounts for approximately 500,000 deaths annually and the total costs due to cancer have been estimated to be $216.6 billion (Cancer Facts & Figures 2014, American Cancer Society).

While much effort has focused on understanding the genetics of cancer, exactly how tumor metabolism contributes to disease progression and its response to treatments has not been established. Changes in cancer metabolism enable cancer cells to proliferate and metastasize. The biochemical changes in cancer cells which determine their behavior in terms of growth, survival and metastasis, also determine their responses to chemotherapy. We are studying cancer metabolism to identify targets for cancer therapy. Cancer cells metabolize sugar differently than normal cells. We believe this can be exploited for therapy eliminating cancer cells while sparing normal cells. We are also identifying metabolic markers that can predict the sensitivity of cancers to drugs that inhibit cancer metabolism. Detecting likely responders and non-responders to particular chemotherapeutic agents is highly desirable because it is important to avoid the use of drugs that have no benefit.

Le Lab operates largely thanks to funds from individuals and organizations. Your donations are crucial and will be put to great use as they allow us to continue these efforts. Your tax-deductible contributions are used exclusively to fund laboratory equipment, supplies and staff salaries. Every dollar brings us one step closer to improving the life of cancer patients and ultimately finding a cure.