Le Cancer Metabolism Research Laboratory


Corresponding author: +
  1. Glucose Metabolism in Cancer. Adv Exp Med Biol. 2018;1063:3-12.
    PMID: 29946772
  2. Glutamine Metabolism in Cancer. Adv Exp Med Biol. 2018;1063:13-32.
    PMID: 29946773
  3. The Heterogeneity of Lipid Metabolism in Cancer. Adv Exp Med Biol. 2018;1063:33-55. PMID: 29946774
  4. The Multifaceted Metabolism of Glioblastoma. Adv Exp Med Biol. 2018;1063:59-72. PMID: 29946775
  5. The Intricate Metabolism of Pancreatic Cancers. Adv Exp Med Biol. 2018;1063:73-81. PMID: 29946776
  6. Breast Cancer Metabolism. Adv Exp Med Biol. 2018;1063:83-93.
    PMID: 29946777
  7. Non-Hodgkin's Lymphoma Metabolism. Adv Exp Med Biol. 2018;1063:95-106. PMID: 29946778
  8. The Metabolism of Renal Cell Carcinomas and Liver Cancer. Adv Exp Med Biol. 2018;1063:107-118. PMID: 29946779
  9. Different Tumor Microenvironments Lead to Different Metabolic Phenotypes. Adv Exp Med Biol. 2018;1063:119-129. PMID: 29946780
  10. The Intratumoral Heterogeneity of Cancer Metabolism. Adv Exp Med Biol. 2018;1063:131-145. PMID: 29946781
  11. Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells. Adv Exp Med Biol. 2018;1063:149-165. PMID: 29946782
  12. Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts. Adv Exp Med Biol. 2018;1063:167-178. PMID: 29946783
  13. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci USA. 2016 Aug 24. PMID: 27559084
  14. Glucose-independent Glutamine-driven TCA Cycle in Cancer Cells. Glutamine in Health and Disease. Glutamine in Clinical Nutrition, Nutrition and Health, DOI 10.1007/978-1-4939-1932-1_6.
  15. Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter. Proc Natl Acad Sci USA. 2014 Aug 26; 111(34): 12486-12491.
    PMID: 25114222.
  16. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012 Jan 4;15(1):110-21. PMID: 22225880.

First author: +
  1. Designing a broad-spectrum integrative approach for cancer prevention and treatment (Equal contribution; authors listed alphabetically). Semin Cancer Biol. 2015 Dec;35 Suppl:S276-304. PMID: 26590477.
  2. Dysregulated Metabolism Contributes to Oncogenesis (Equal contribution; authors listed alphabetically). Semin Cancer Biol. 2015 Dec;35 Suppl:S129-50. PMID: 26454069.
  3. Studying Myc's role in metabolism regulation. Methods Mol Biol. 2013;1012:213-9. PMID: 24006067.
  4. Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors (Co-first author). Cancer Res. 2013 Jul 15;73(14):4190-5. PMID: 23722553.
  5. Conceptual framework for cutting the pancreatic cancer fuel supply. Clin Cancer Res. 2012 Aug 15;18(16):4285-90. PMID: 22896695.
  6. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA. 2010 Feb 2; 107(5):2037-42. PMID: 20133848.
  7. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med. 2009 Sep 1;180(5):396-406. PMID: 19520907.
  8. Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury. J Appl Physiol (1985). 2008 Oct;105(4):1282-90. PMID: 18669934.

Co-author: +
  1. Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation. Free Radic Biol Med. 2018 Apr 9. pii: S0891-5849(18)30174-6. PMID: 29649567.
  2. Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment. Oncogene. 2017 Sep 4. PMID: 28869602.
  3. Discovery of 6-Diazo-5-oxo-L-norleucine (DON) prodrugs with enhanced CSF delivery in monkeys a potential treatment for glioblastoma. J Med Chem. 2016 Aug 25. PMID: 27560860.
  4. Allosteric Glutaminase Inhibitors Based on a 1, 4-Di (5-amino-1, 3, 4-thiadiazol-2-yl) butane Scaffold. ACS Med Chem Lett. 2016 Mar 13;7(5):520-4. PMID: 27200176
  5. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest. 2015 Jun 1;125(6):2293-306. PMID: 25915584.
  6. Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function. Cancer Res. 2015 Aug 15;75(16):3355-64. PMID: 26113084
  7. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife. 2014 Jul 9;3. PMID: 25009227.
  8. Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung. PLoS Genet. 2013;9(2):e1003228. PMID: 23459311.
  9. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci USA. 2012 Jun 5;109(23):8983-8. PMID: 22615405.
  10. Metabolic and electrochemical mechanisms of dimeric naphthoquinones cytotoxicity in breast cancer cells. Bioorg Med Chem. 2011 Dec 1;19(23):7057-62. PMID: 22036210.
  11. Therapeutic targeting of cancer cell metabolism. J Mol Med (Berl). 2011 Mar;89(3):205-12. PMID: 21301795.
  12. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci USA. 2010 Feb 23;107(8):3534-9. PMID: 20133585.
  13. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009 Nov 1;15(21):6479-83. PMID: 19861459.
  14. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. PLoS One. 2009;4(2):e4600. PMID: 19240800.