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Joseph Herman, M.D., M.Sc.

Joseph Herman, M.D., M.Sc.
Co-Director, Pancreatic Cancer Multidisciplinary Clinic
Director of Clinical Research, Department of Radiation Oncology
Associate Professor of Radiation Oncology and Molecular Radiation Sciences
Associate Professor of Oncology
Associate Professor of Surgery

Appointment Phone: 410.502.8000

Dr. Herman is the director of the pancreatic multi-disciplinary clinic and focuses on translational treatments for gastrointestinal malignancies. His research interests include innovative combinations of stereotactic radiation with immunotherapy and targeted agents for pancreatic and liver cancers. Other interests include outcomes reasearch and treatment related quality of life. He specializes in intraoperative radiation therapy for recurrent malignancies and endorectal brachtherapy for early stage rectal cancers.

Selected Publications

  • Tryggestad E, Flammang A, Han-Oh S, Hales R, Herman J, McNutt T, Roland T, Shea SM, Wong J. Respiration-based Sorting of Dynamic MRI to Derive Representative 4D-MRI for Radiotherapy Planning. Med Phys. 2013 May;40(5):051909.

  • Wild A, Ye X, Ellsworth SG, Smith JA, Narang AK, Garg T, Campian J, Laheru DA, Zheng L, Wolfgang CL, Tran PT, Grossman S, Herman JM. The Association between Chemoradiation-related Lymphopenia and Clinical Outcomes in Patients with Locally Advanced Pancreatic Adenocarcinoma. Am J Clin Oncol. 2013 May 2. [Epub ahead of print] PMID: 23648440.

  • Wild AT, Gandhi N, Chettiar ST, Aziz K, Gajula RP, Williams RD, Kumar R, Taparra K, Zeng J, Cades JA, Velarde E, Menon S, Geschwind JF, Cosgrove D, Pawlik TM, Maitra A, Wong J, Hales RK, Torbenson MS, Herman JM, Tran PT. Concurrent versus Sequential Sorafenib Therapy in Combination with Radiation for Hepatocellular Carcinoma. PLoS One, 2013 Jun 6;8(6):e65726. PMC3675179.

  • Elnahal SM, Pronovost PJ, Herman JM. More Than the Sum of Its Parts: How Multidisciplinary Cancer Care Can Benefit Patients, Providers, and Health Systems. J Natl Compr Canc Netw. 2013 Jun 1;11(6):738-742.

  • Herman JM, Fan KY, Wild AT, Hacker-Prietz A, Wood LD, Blackford AL, Ellsworth S, Zheng L, Le DT, De Jesus-Acosta A, Hidalgo M, Donehower RC, Schulick RD, Edil BH, Choti MA, Hruban RH, Pawlik TM, Cameron JL, Laheru DA, Wolfgang CL. Phase 2 Study of Erlotinib Combined with Adjuvant Chemoradiation and Chemotherapy in Patients with Resectable Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):678-685.

  • Alcorn S, Walker AJ, Gandhi N, Narang A, Wild AT, Hales RK, Herman JM, Song DY, DeWeese TL, Antonarakis ES, Tran PT. Molecularly Targeted Agents as Radiosensitizers in Cancer Therapy – Focus on Prostate Cancer. Int J Mol Sci. 2013 Jul 16;14(7):14800-14832. PMC3742274.

  • Cooper M, Newman NA, Ibrahim AM, Lam E, Herman JM, Singh VK, Wolfgang CL, Pawlik TM, Cameron JL, Makary MA. Unnecessary Tests and Procedures in Patients Presenting with Solid Tumors of the Pancreas. J Gastrointest Surg. 2013 Jul;17(7):1218-1223. [Epub 2013 May 4].

  • Hyder O, Chung M, Cosgrove D, Herman JM, Li Z, Firoozmand A, Gurakar A, Koteish A, Pawlik, TM. Cadmium Exposure and Liver Disease in U.S. Adults. J. Gastrointest Surg. 2013 Jul;17(7):1265-1273. [Epub 2013 May 1].

  • Hyder O, Dodson RM, Sachs T, Weiss M, Mayo SC, Choti MA, Wolfgang CL, Herman JM, Pawlik TM. Impact of Adjuvant External Beam Radiotherapy on Survival in Surgically Resected Gallbladder Adenocarcinoma: A Propensity Score-matched Surveillance, Epidemiology, and End Results Analysis. Surgery. 2013 Jul 19. [Epub ahead of print].

  • Katz MHG, Marsh R, Herman JM, Shi Q, Collison E, Venook A, Kindler H, Alberts S, Philip P, Lowy AM, Pisters P, Posner M, Berlin J, Ahmad SA. Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design. Ann Surg Oncol. 2013 Aug;20(8):2787-2795. [Epub 2013 Feb 23].

  • Kim EJ, Ben-Josef E, Herman JM, Bekaii-Saab T, Dawson LA, Griffith KA, Francis IR, Greenson JK, Simeone DM, Lawrence TS, Laheru D, Wolfgang CL, Williams T, Bloomston M, Moore MJ, Wei A, Zalupski MM. A Multi-Institutional Phase 2 Study of Neoadjuvant Gemcitabine and Oxaliplatin with Radiation Therapy in Patients with Pancreatic Cancer. Cancer. 2013 Aug 1;119(15):2692-2700. [Epub 2013 May 29].

  • Hyder O, Dodson R, Mayo S, Schneider EB, Weiss M, Herman JM, Wolfgang CL, Pawlik TM. Post-Treatment Surveillance of Patients with Colorectal Cancer with Surgically Treated Liver Metastases. Surgery. 2013 Aug;154(2):256-265.

  • Schneider EB, Hyder O, Wolfgang CL, Dodson RM, Haider AH, Herman JM, Pawlik TM. Provider versus Patient Factors Impacting Hospital Length of Stay after Pancreaticoduodenectomy. Surgery.2013 Aug;154(2):152-161.

  • Stacy S, Hyder O, Cosgrove D, Herman JM, Kamel I, Geschwind JF, Gurakar A, Anders R, Cameron A, Pawlik TM. Patterns of Consultation and Treatment of Patients with Hepatocellular Carcinoma Presenting to a Large Academic Medical Center in the US. J Gastrointest Surg. 2013 Sep;17(9):1600-1608. [Epub 2013 Jun 19].

  • Tryggestad E, Flammang A, Hales R, Herman J, Lee J, McNutt T, Roland T, Shea SM, Wong J. 4D Tumor Centroid Tracking Using Orthogonal 2D Dynamic MRI: Implications for Radiotherapy Planning. Med Phys. 2013 Sep;40(9):091712. doi: 10.1118/1.4818656.

  • Walker AJ, Alcorn SR, Narang AK, Nugent KM, Wild AT, Herman JM, Tran PT. Radiosensitizers in Pancreatic Cancer-Preclinical and Clinical Exploits with Molecularly Targeted Agents. Curr Probl Cancer. 2013 Sep-Oct;37(5):301-312. [Epub 2013 Oct 5].

  • Wild AT, Fan KY, Herman JM. Management of Pancreatic Cancer. Curr Probl Cancer. 2013 Sep-Oct;37(5):259-261. [Epub 2013 Oct 7].

  • Hung J, Hiniker SM, Lucas DR, Griffith KA, McHugh JB, Meirovitz A, Thomas DG, Chugh R, Herman JM. Sporadic versus Radiation-Associated Angiosarcoma: A Comparative Clinicopathologic and Molecular Analysis of 48 Cases. Sarcoma. 2013;2013:798403. [Epub 2013 Sep 3].

  • Kumar R, Wild AT, Ziegler MA, Smith K, Kang J, Hooker TK, Dah SD, Tran PT, Zeng J, Pawlik TM, Tryggestad E, Ford E, Herman JM. Stereotactic Body Radiation Therapy Planning with Duodenal Sparing Using Volumetric Modulated Arc Therapy versus Intensity Modulated Radiation Therapy for Locally Advanced Pancreatic Cancer: A Dosimetric Analysis. Med Dosim. 2013 Autumn;38(3):243-250. [Epub 2013 Mar 27].

  • Benson AB 3rd, Geschwind JF, Mulcahy MF, Rilling W, Siskin G, Wiseman G, Cunningham J, Houghton B, Ross M, Memon K, Andrews J, Fleming CJ, Herman J, Nimeiri H, Lewandowski RJ, Salem R. Radioembolisation for Liver Metastases: Results From a Prospective 151 Patient Multi-Institutional Phase II Study. Eur J Cancer. 2013 Oct;49(15):3122-3130. [Epub 2013 Jun 15]

  • Hyder O, Dodson RM, Weiss M, Cosgrove DP, Herman JM, Geschwind JF, Kamel IR, Pawlik TM. Trends and Patterns of Utilization in Post-treatment Surveillance Imaging Among Patients Treated for Hepatocellular Carcinoma. J Gastrointest Surg. 2013 Oct;17(10):1774-1783. [Epub 2013 Aug 14].

  • Dodson RM, Weiss MJ, Cosgrove D, Herman JM, Kamel I, Anders R, Geschwind JF, Pawlik TM. Intrahepatic Cholangiocarcinoma: Management Options and Emerging Therapies. J Am Coll Surg. 2013 Oct;217(4):736-750. [Epub 2013 Jul 24].

  • Herman JM, Fan KY, Wild AT, Hacker-Prietz A, Wood LD, Blackford AL, Ellsworth S, Zheng L, Le DT, De Jesus-Acosta A, Hidalgo M, Donehower RC, Schulick RD, Edil BH, Choti MA, Hruban RH, Pawlik TM, Cameron JL, Laheru DA, Wolfgang CL. Correlation of Smad4 Status with Outcomes in Patients Receiving Erlotinib Combined with Adjuvant Chemoradiation and Chemotherapy Following Resection for Pancreatic Adenocarcinoma.Int J Radiat Oncol Biol Phys. 2013 Nov 1;87(3):458-459.

  • Gajula RP, Chettiar ST, Williams RD, Thiyagarajan S, Kato Y, Aziz K, Wang R, Gandhi N, Wild AT, Vesuna F, Ma J, Salih T, Cades J, Fertig E, Biswal S, Burns TF, Chung C, Rudin CM, Herman JM, Hales RK, Raman V, An SS, Tran PT. The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis. Mol Cancer Res. 2013 Nov;11(11):1387-1400. [Epub 2013 Aug 27]. PMC3833995.

  • Hyder O, Dodson RM, Nathan H, Herman JM, Cosgrove D, Kamel I, Geschwind JF, Pawlik TM. Referral Patterns and Treatment Choices for Patients with Hepatocellular Carcinoma: A United States Population-Based Study. J Am Coll Surg. 2013 Nov;217(5):896-906 [Epub 2013 Sep 13].

  • Dholakia AS, Kumar R, Raman SP, Moore JA, Ellsworth S, McNutt T, Laheru DA, Jaffee E, Cameron JL, Tran PT, Hobbs RF, Wolfgang CL, Herman JM. Mapping Patterns of Local Recurrence after Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: A New Approach to Adjuvant Radiation Field Design. Int J Radiat Oncol Biol Phys. 2013;87(5):1007-1015.

  • Salman B, Brat G, Yoon YS, Hruban RH, Singhi AD, Fishman EK, Herman JM, Wolfgang CL. The Diagnosis and Surgical Treatment of Pancreatoblastoma in Adults: A Case Series and Review of the Literature. J Gastrointest Surg. 2013 Dec;17(12):2153-2161. [Epub 2013 Oct 1].

  • Hyder O, Dodson RM, Nathan H, Schneider EB, Weiss MJ, Cameron JL, Choti MA, Makary MA, Hirose K, Wolfgang CL, Herman JM, Pawlik TM. Influence of Patient, Physician, and Hospital Factors on 30-Day Readmission Following Pancreatoduodenectomy in the United States. JAMA Surg. 2013 Dec 1;148(12):1095-1102.

  • Wild AT, Hiniker SM, Chang DT, Tran PT, Khashab MA, Limaye MR, Laheru DA, Le DT, Kumar R, Pai JS, Hargens B, Sharabi AB, Shin EJ, Zheng L, Pawlik TM, Wolfgang CL, Koong AC, Herman JM. Re-irradiation with Stereotactic Body Radiation Therapy as a Novel Treatment Option for Isolated Local Recurrence of Pancreatic Cancer after Multimodality Therapy: Experience from Two Institutions. J Gastrointest Oncol. 2013; Dec;4(4):343-351.

  • Dodson RM, Firoozmand A, Hyder O, Tacher V, Cosgrove DP, Bhagat N, Herman JM, Wolfgang CL, Geschwind JF, Kamel IR, Pawlik TM. Impact of Sarcopenia on Outcomes Following Intra-arterial Therapy of Hepatic Malignancies. J Gastrointest Surg. 2013 Dec;17(12):2123-2132. [Epub 2013 Sep 25].

  • Schueneman AJ, Sugar EA, Uram J, Bigelow E, Herman JM, Edil BH, Jaffee EM, Zheng L, Laheru DA. Low Total Lymphocyte Count Is Associated with Poor Survival in Patients with Resected Pancreatic Adenocarcinoma Receiving a GM-CSF Secreting Pancreatic Tumor Vaccine. Ann Surg Oncol. 2013 Dec;20 Suppl 3:725-730. [Epub 2013 Sep 18].

  • Gleisner AL, Mogal H, Dodson R, Efron J, Gearhart S, Wick E, Lidor A, Herman JM, Pawlik TM. Nodal Status, Number of Lymph Nodes Examined, and Lymph Node Ratio: What Defines Prognosis after Resection of Colon Adenocarcinoma? J Am Coll Surg. 2013 Dec;217(6):1090-1100. [Epub 2013 Sep 14].

  • Sharabi A, Herman J, Weiss V, Laheru D, Tuli R. Role of Radiotherapy in Combination with Chemotherapy, Targeted Therapy, and Immunotherapy in the Management of Pancreatic Cancer. J Radiation Oncology. 2013 Dec;2(4):369-379.

  • Dholakia AS, Hacker-Prietz A, Wild AT, Raman SP, Wood LD, Huang P, Laheru DA, Zheng L, De Jesus-Acosta A, Le DT, Schulick R, Edil B, Yovino S, Pawlik TM, Iacobuzio-Donahue CA, Hruban RH, Cameron JL, Fishman EK, Wolfgang CL, Herman JM. Resection of Borderline Resectable Pancreatic Cancer after Neoadjuvant Chemoradiation Does Not Depend on Improved Radiographic Appearance of Tumor-Vessel Relationships. J Radiation Oncology. 2013 Dec;2(4):413-425.

  • Soares KC, Cosgrove DC, Herman JM, Pawlik TM. Multidisciplinary Clinic in the Management of Hepatocellular Carcinoma. Ann Surg Oncol. 2013 Dec 7. [Epub ahead of print].

  • Faisal F, Tsai HL, Blackford A, Olino K, Xia C, De Jesus-Acosta A, Le DT, Cosgrove D, Azad N, Rasheed Z, Diaz LA Jr, Donehower R, Laheru D, Hruban RH, Fishman EK, Edil BH, Schulick R, Wolfgang C, Herman J, Zheng L. Longer Course of Induction Chemotherapy Followed by Chemoradiation Favors Better Survival Outcomes for Patients With Locally Advanced Pancreatic Cancer. Am J Clin Oncol. 2013 Dec 17. [Epub ahead of print].

  • Fan KY, Dholakia AS, Wild AT, Su Z, Hacker-Prietz A, Kumar R, Hodgin M, Hsu CC, Le DT, De Jesus-Acosta A, Diaz Jr LA, Laheru DA, Hruban RH, Fishman EK, Brown TD, Pawlik TM, Wolfgang CL, Tran PT, Herman JM. Hemoglobin-A1c Level Predicts for Clinical Outcomes in Patients with Pancreatic Cancer. J Natl Compr Canc Netw. 2014 Jan 1;12(1):50-57.

  • Mayo SC, Mavros MN, Nathan H, Cosgrove D, Herman JM, Kamel I, Anders RA, Pawlik TM. Treatment and Prognosis of Patients with Fibrolamellar Hepatocellular Carcinoma: A National Perspective. J Am Coll Surg. 2014 Feb;218(2):196-205. [Epub 2013 Oct 24].

  • Reese JB, Finan PH, Haythornthwaite JA, Kadan M, Regan KR, Herman JM, Efron JE, Diaz Jr LA, Azad NS. Gastrointestinal Ostomies and Sexual Outcomes: A Comparison of Colorectal Cancer Patients by Ostomy Status. Support Care Cancer 2014 Feb;22(2):461-468. [Epub 2013 Oct 5].