Johns Hopkins Pathology

  • Abdominal pain or discomfort

Mucinous cystic neoplasms are relatively uncommon. They account for only 5.7% of all primary pancreatic tumors seen in consultation at the Armed Forces Institute of Pathology. In some reported series of mucinous cystic neoplasms all of the patients have been female, however, well-documented cases have been reported in men, and a female to male ratio of 90:10 is probably reasonable. The mean age at diagnosis is between 40 to 50 years with a range of 14-95 years. In most series of mucinous cystic neolasms, patients with mucinous cystadenocarcinomas are 5 to 10 years older than the patients with benign mucinous cystic neoplasms.

Mucinous cystic neoplasms have not been associated with any genetic syndromes.

Most patients with mucinous cystic neoplasms present with vague abdominal symptoms that include epigastric pain or a sense of abdominal fullness.Less commonly, the patients develop gastrointestinal symptoms including nausea and vomiting, diarrhea, anorexia, and weight loss. As many as 20% of mucinous cystic neoplasms are discovered incidentally during abdominal imagingfor an unrelated indication. Only a small minority of the patients present with jaundice. Those that do present with jaundice usually have mucinous cystadenocarcinomas involving the head of the gland. Mucinous cystic neoplasms can sometimes be palpated in the left upper quadrant on physical examination.


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