Johns Hopkins Pathology
 
Key Points:
  • Pseudocysts

The differential diagnosis of solid-pseudopapillary neoplasms includes pseudocysts and other pancreas cysts. However, histological features like pseudopapillary areas and microvasculature should clearly differentiate it from other pancreas cysts. The unique feature of a solid-pseudopapillary neoplasm is the tumor cell, containing foamy cytoplasm, mesenchymal, endocrine, and epithelial differentiation.

In difficult cases, immunostaining for CD 10 and beta-catenin can help establish diagnosis.

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