Johns Hopkins Pathology

Key Points:
  • Benign
    Associated with von Hippel-Landau Syndrome

Serous Cysts are epithelial neoplasms composed of uniform cuboidal glycogen-rich cells that usually form numerous small cysts containing serous fluid. Almost all are benign, however, rare malignant serous cystadenocarcinomas have been reported.

Serous cystadenomas (SCA) have also been know as: microcystic adenoma, serous microcystic adenoma, macrocystic SCA, serous oligocystic and ill-defined adenoma, and glycogen-rich cystadenoma. Serous cystadenomas are associated with von Hippel-Landau syndrome (VHL), an autosomal dominant disorder characterized by hemangioblastomas of the central nervous system (CNS) and retina, renal neoplasms and cysts, and pheochromocytomas. The pancreatic lesions attributed to VHL may develop earlier than CNS lesions, thereby indicating VHL.


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