Pathology Research Brochure

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Division of Autopsy Pathology

Email bcrain@jhmi.edu

Phone (410) 502-5167

Barbara J. Crain, M.D., Ph.D.
Director, Autopsy Division
Primary Appointment in Pathology; Secondary Appointments in Neurology and Oncology

My interests concern patterns and mechanisms of neuronal vulnerability in different disease states. Many of my current interests are in the areas of neurodegenerative disease and stroke, and I therefore collaborate with the Alzheimer's Disease Research Center, the Parkinson's Center, and the Huntington's Center. I am also interested in the fate of bone marrow cells after transplantation. We have examined the brains of female patients who received bone marrow transplants from males and found neurons containing Y-chromosomes. Occasional glial and blood vessels cells also contain Y-chromosomes. Finally, I continue to collaborate with faculty in Anesthesiology and Critical Care Medicine on studies of animal models of stroke.

Publications

Mezey, E., Key, S., Vogelsang, G., Szalayova, I., Lange, G. D., and Crain, B. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci U S A, 100:1364-9, 2003.
Hatanpaa, K.J., Blass, D.M., Pletnikova, O., Crain, B.J., Bigio, E.H., Hedreen, J.C., White, I.C.L., Troncoso, J.C. Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology, 63:538-542, 2004.
Toung, T.J.K., Chang, Y., Williams, M., Crain, B.J., Traystman, R.J., Bhardwaj, A. Experimental spinal cord ischemia: model characterization and improved outcome with arterial hypertension. Crit Care Med, 32:1346-51, 2004

Email	mhalush1@jhmi.edu
Phone	(410) 614-8138

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Marc K. Halushka, M.D., Ph.D.

Primary Appointment in Pathology

Vascular disease is the primary cause of morbidity and mortality among diabetics. My laboratory is investigating the role of advanced glycation end products (AGEs) on endothelial dysfunction. We are primarily working with human coronary and aortic endothelial cells in vitro to establish the role of AGEs on endothelial-mesenchymal transdifferentiation (EndoMT). We are also developing an animal model to study the role of AGEs on EndoMT.

Publications

Halushka MK, Selvin E, Lu J, Macgregor AM, Cornish TC. The Use of Human Vascular Tissue Microarrays for Measurement of Advanced Glycation End Products. J Histochem Cytochem. 2009 Feb 16.
Halushka MK, Cornish TC, Lu J, Selvin S, Selvin E. Creation, validation, and quantitative analysis of protein expression in vascular tissue microarrays. Cardiovasc Pathol. 2009 Feb 10
Maleszewski JJ, Miller DV, Lu J, Dietz HC, Halushka MK. Histopathologic findings in ascending aortas from individuals with Loeys-Dietz syndrome (LDS). Am J Surg Pathol. 33(2):194-201, 2009.
Maleszewski J, Lu J, Fox-Talbot K, Halushka MK. Robust immunohistochemical staining of several classes of proteins in tissues subjected to autolysis. J Histochem Cytochem. 55(6):597-606, 2007.
Halushka MK, Walker LP, Halushka PV. Genetic variation in cyclooxygenase 1: effects on response to aspirin. Clin Pharmacol Ther. Jan;73(1):122-30, 2003.
Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. Jul;22(3):239-47, 1999.

Email	ghutchi@jhmi.edu
Phone	(410) 955-3765
Related Websites
Division of Cardiovascular Pathology

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Grover M. Hutchins, M.D.

Interim Director, Division of Cardiovascular Pathology
Primary Appointment in Pathology; Secondary Appointment in Art as Applied to Medicine
Member, Graduate Program in Medical and Biological Illustration

My investigations are primarily on the pathogenesis of various abnormalities based on study of patients at autopsy. Particular interests are in cardiovascular, pulmonary, and pediatric pathology. The studies are generally conducted by review of the appropriate clinical and pathologic features of the cases.

Publications

Volmar, Keith E., Fritsch, Michael K., Perlman, Elizabeth J. and Hutchins, Grover M.: Patterns of congenital lower urinary tract obstructive uropathy:Relation to abnormal prostate and bladder development and the prune bellysyndrome. Pediatr Dev Pathol 4:467-472, 2001.
Volmar, Keith E. and Hutchins, Grover M. Aortic and mitralfenfluramine-phentermine valvulopathy in 64 patients treated with anorecticagents. Arch Pathol Lab Med 125:1555-1561, 2001.
Haderer, Joanne M., Pannu, Harpreet K. Genadry, Rene, Hutchins, GroverM. Controversies in female urethral anatomy and their significance for understanding urinary continence: observations and literature review. Int Urogynecol J Pelvic Floor Dysfunct 13:236-252,2002
Rogers, Daniel S., Paidas, Charles N., Morreale, Robert F., Hutchins,Grover M. Septation of the anorectal and genitourinary tracts in the human embryo: Crucial role of the catenoidal shape of the urorectal sulcus.Teratology 66:144-152,2002