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Division of Autopsy Pathology


Email jhooper9@jhmi.edu
Phone (410) 955-3765

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Rapid Autopsy


Jody E. Hooper, M.D.

Primary Appointment in Pathology;
Director, Legacy Gift Rapid Autopsy Program;
Deputy Director, Division of Autopsy


“Rapid” autopsy means conducting a postmortem examination of a patient on an urgent basis to collect tissue (mostly cancers) for many different types of research. This allows for investigation of large volumes of tumor tissue at a unique time point in the evolution of the tumor from a genetic and immunologic standpoint, when aggressive local and distant spread has occurred. My major focus is on expanding the Hopkins Rapid Medical Donation (rapid autopsy) program from a few subspecialized areas to encompass all organ systems and many laboratories. I have a number of research interests associated with my autopsy work, including how the time interval between death and collection affects the condition of the tissue, how valuable blood and tissue cultures are after death, and how autopsy results affect clinical practice.

Publications
Hooper JE, Hebert J, Schilling A, Gross N, Schindler J, Lagowski J, Kulesz-Martin M, Corless C, Morgan TK. “Hybrid Capture 2 is as effective as PCR testing for high risk HPV in head and neck cancers.” Diag Mol Pathol 2014 [epub ahead of print].

Kikuchi K, Wettach GR, Ryan CR, Hung A, Hooper JE, Beadling C, Warrick A, Corless CL, Olson SB, Hart J, Vogt PK, Keller C, Mansoor A. "MDM2 amplification and PI3KCA mutation in a case of sclerosing rhabdomyosarcoma". Sarcoma 2013; http://www.hindawi.com/journals/sarcoma/2013/520858/.

Alabran JL, Hooper JE, Hill M, Smith SE, Spady KK, Davis LE, Peterson LS, Malempati S, Ryan CW, Acosta R, Spunt SL, Keller C. “Overcoming autopsy barriers in pediatric cancer research”. Pediatric Blood and Cancer 2013;60(2):204-209.

Hooper JE, Morgan TK, Grompe M, Sheppard BC, Troxell ML, Corless CL, Streeter PR. “The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma”. Human Pathology 2012;43(10):1583-1589.

Hooper JE, Geller SA. “Relevance of the autopsy as a medical tool: a large database of physician attitudes”. Archives of Pathology & Laboratory Medicine 2007; 131 (2): 268-274.




Email mhalush1@jhmi.edu
Phone (410) 614-8138
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Marc K. Halushka, M.D., Ph.D.

Primary Appointment in Pathology


MicroRNAs are key post-translational regulators of genes. We are interested in the distribution of microRNAs in human tissues and cells. We are also interested in determining how these microRNAs are altered in human diseases. My laboratory is also involved in a number of collaborative projects relating to cardiovascular diseases such as sudden cardiac death, cardiac citrullination and neonatal lupus.

Publications
McCall MN, Kent OA, Yu J, Fox-Talbot K, Zaiman AL, Halushka MK. MicroRNA profiling of diverse endothelial cell types. BMC Med Genomics, 4(1):78, 2011.

Gupta S*, Halushka MK*, Hilton GM, Arking DE. Postmortem cardiac tissue maintains gene expression profile even after late harvesting. BMC Genomics, 13(1):26, 2012.

Giles JT, Fert-Bober J, Park JK, Bingham CO 3rd, Andrade F, Fox-Talbot K, Pappas D, Rosen A, van Eyk J, Bathon JM, Halushka MK. Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study.. Arth Res Ther. 14(1):R39, 2012.

Kent OA, Fox-Talbot K, Halushka MK. RREB1 repressed miR-143/145 modulates KRAS signaling through down regulation of multiple targets. In Press Oncogene, 2012.

Maleszewski JJ, Murray DL, Dispenzieri A, Grogan M, Judge DP, Caturegli P, Vrana JA, Theis JD, Dogan A, Halushka MK. Relationship between monoclonal gammopathy and cardiac amyloid type. Cardiovasc Pathol, In Press 2012.



 


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