Email mfraig1@jhmi.edu Phone (410) 550-0669

Top of Page Mostafa Fraig, M.D. Primary Appointment in Pathology My research is focused in the study of neoplastic and non neoplastic lung diseases. Pulmonary hypertension and acute lung injury are two areas where we study the underlying cellular interaction and role of different modulating factors in the histomorphologic changes noted in these diseases. Wide use of immunohistochemical staining to recognize and localize the effect of these factors in our animal models is an area where I make my contribution. Clinicopathologic studies involving cases of interstitial lung disease to better define and understand these entities represent another area of interest. Another area of expertise is in respiratory cytopathology and the use of guided FNA in the diagnosis and staging of lung cancer. Publications Fraig M., Shreesha U., Savici D., and Katzenstein A-L. Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers and never-smokers. Am J Surg Path, 2002, Vol. 26 (5); pp 647-653 Vincent BD., Fraig MM., and Silvestri GA. A pilot study of narrow-band imaging compared to white light bronchoscopy for evaluation of normal airways and premalignant and malignant airways disease. Chest, 131(6): 1794-1799, 2007 Moussa O., Riker M J., Klein J., Fraig MM., Halushka PV., and Watson D.K. Inhibition of Thromboxane Synthase activity modulate bladder cancer cell responses to chemotherapeutic agents. Oncogene (2008) 27, 55-62 published on line, July 2007 Garwood S., Judson M., Silvestri G., Fraig M. and Doelken P. Endobronchial ultrasound for the diagnosis of pulmonary sarcoidosis. Chest 131 (4):1298-304, 2007. Watson PM., Miller SW., Fraig M., Cole DJ., Watson DK., and Boylan CaSm (LSm-1) over-expression in lung and mesothelioma is required for transformed phenotypes. Am J of Respir Cell Mol Biol, epublished in jan 2008.

Email wwestra@jhmi.edu Phone (410) 614-3964

Top of Page William H. Westra, M.D. Co-Director, Division of Surgical Pathology Primary Appointment in Pathology; Secondary Appointments in Otolaryngology-Head and Neck Surgery, Oncology, and Dermatology My research activities have centered on the molecular mechanisms of neoplastic transformation. My specific interest in cardiovascular-respiratory pathology has focused on the molecular pathways involved in the development and progression of neoplasms of the lung and head and neck. Our work has identified the earliest morphologic stages of lung tumorigenesis (i.e. adenocarcinoma in situ), and the molecular mechanisms driving the early stages and progression of carcinomas of the lung and head and neck. A particular emphasis of this work has been the utilization of specific genetic alterations as a novel means of early cancer detection and tumor surveillance. Publications Westra WH, Baas IO, Hruban RH, Offerhaus GJA, Askin FB, Slebos RJC. K-ras oncogene activation in atypical alveolar hyperplasias of the lung: evidence that K-ras mutations are present at an early stage in the development of lung adenocarcinomas. Cancer Res 56:2224-8, 1996.. Leong PP, Rezai B, Roch WM, Reed A, Eisele D, Lee D-J, Sidransky D, Jen J,Westra WH. Distinguishing Second Primary Tumors from Lung Metastases in Patients with Head and Neck Squamous Cell Carcinoma. J Natl Cancer Inst 90:972-977, 1998. Califano J, Westra WH, Koch WM, Meininger G, Reed A, Yip L, Boyle JO, Lonardo F, Sidransky D. Unknown primary head and neck squamous cell carcinoma: Molecular identification of the site of origin. J Natl Cancer Inst 91:599-604, 1999. Begum S, Gillison ML, Ansari-Lari MA, Shah K, Westra WH. Detection of Human Papillomavirus in Cervical Lymph Nodes: A highly effective strategy for localizing site of tumor origin. Clin Cancer Res 15:6469-6475, 2003. Cohen Y, Rosenbaum E, Clark DP, Zeiger MA, Umbricht CB, Tufano RP, Sidransky S, Westra WH. Mutational analysis of BRAF in fine needle aspiration biopsies of the thyroid: A potential application for the preoperative assessment of thyroid nodules. Clin Cancer Res 10:2761-2765, 2004.