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Division of Cytopathology


Email sali@jhmi.edu
Phone (410) 955-1180

Related Websites
Hopkins Cytopathology

Cytopathology Tutorials

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Syed Z. Ali, M.B.B.S.

Director, Division of Cytopathology; Primary Appointment in Pathology; Secondary Appointment in Radiology


Fine needle aspiration (FNA) has a widely recognized and established role as the initial diagnostic modality in most neoplastic and inflammatory disorders of the viscera and soft tissues. My major interest is focused on clinico-morphologic studies primarily based on FNA of breast, salivary glands, liver and soft tissues with integration of clinico-radiologic data and ancillary techniques such as immuno-cytochemistry and molecular genetics. These latter techniques not only augment our morphologic diagnoses in difficult cases, but often also provide important pathogenetic and prognostic information about these lesions.

Digital photo imaging and telepathology is rapidly emerging as a major tool, not only in education and research, but also in diagnostic pathology. By utilizing state-of-the-art imaging equipment, I am involved in several on-going projects in this exciting new field ranging from web-based tutorials to sophisticated virtual photomicroscopy.

Publications

Kulesza P, Torbenson M, Sheth S, Erozan YS, Ali SZ. Cytopathologic grading of hepatocellular carcinoma on fine needle aspiration. Cancer 2004;102:247-258

Swierczynski SL, Lewis-Chambers S, Anderson JR, Keller JM, Hinkle DA, Ali SZ. Impact of liquid-based gynecologic cytology on a human immunodeficiency virus-positive population. Acta Cytol 2004;48:165-172

Ali SZ. Acinic cell carcinoma, papillary-cystic variant: A diagnostic dilemma in salivary gland aspiration. Diagn Cytopathol 2002;27:244-250

Steinberg DM, Chan TY, Freedman JA, Grimm LA, Ling L, Lehmann HP,Burroughs F, Rosenthal DL and Ali SZ. Teaching cytopathology to second-year medical students: An interactive, case-based approach. Acta. Cytol. 46(3)481-489, 2002.

Steinberg DM and Ali SZ. Application of virtual microscopy in clinical cytopathology. Diagn. Cytopathol. 25:389-396, 2001.




Email qli23@jhmi.edu
Phone (410) 550-0669
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Qing K Li, M.D., Ph.D.

Primary Appointment in Pathology


My main research interest is to apply the advanced technology of cellular and molecular biology to the field of cytopathology, particularly in the area of early detection of lung cancers. Currently, my research is focused on: (1) detection of circulating tumor cells in non-small cell lung cancer patients; (2) identifying what molecular markers and intracellular signal transduction pathways are involved, (3) and discovering novel molecular biomarkers with early diagnostic and prognostic significance.

Identification and utilization of these molecular markers not only augment our morphologic diagnoses in difficult cases, but also provide important pathogenetic and prognostic information of lung cancers.

Publications

Li Q, Subbulakshmi V, Oldfield C, Aamir R, Weyman CM, Wolfman A and Cathcart MK. Protein kinase C alpha regulates phosphorylation and enzymatic activity of cytosolic phospholipase A2 in vitro and in activated human monocytes. Cell Signal 2006. In press.

Li Q, Bavikatty N, and Michael CW. The role of Immunohistochemistry in the distinguishing squamous cell carcinoma from mesothelioma and adenocarcinoma in pleural effusion. Seminars of Diagnostic Pathol. 2006; 23:15.

Li Q, Murphy M, Ross JS, Sheehan C and Carlson JA. Skp2 and p27 kip1 expression in melanocytic nevi and melanoma: an inverse relationship. J. Cutan. Pathol. 2004; 31:633.




Email zmaleki1@jhmi.edu
Phone (410) 550-5220
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Zahra Maleki, M.D.

Primary Appointment in Pathology


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Publications
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Email molson8@jhmi.edu
Phone (410) 955-1180
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Matthew T. Olson, M.D.

Primary Appointment in Pathology


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Publications
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Email drosenthal@jhmi.edu
Phone (410) 550-4841

Related Websites
Division of Cytopathology

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Dorothy L. Rosenthal, M.D.

Primary Appointment in Pathology; Secondary Appointments in Oncology and Gynecology-Obstetrics


As a clinically-oriented cytopathologist, my research efforts are directed at answering diagnostic questions which are difficult or impossible when relying solely on morphologic features. Cervico-vaginal specimens (Pap smears) are perhaps the most challenging samples facing the cytologist. I have devoted much of my career to seeking ways to augment light microscopic diagnoses via computers. Neural networks combined with traditional image processing techniques have shown promise for automated scanning of slides. The ability of such systems to detect rare abnormal cells for human verification is currently being validated, but they promise to reduce the error rate of Pap Test interpretation. Our cytologists continue to be involved in the development of these devices.

Identification of molecular markers to diagnose high grade pre-malignant lesions (HSIL) of the uterine cervix is an exciting collaborative effort with members of our division and with TriPath Oncology, a subsidiary of TriPath Imaging. Not only will the markers enable location of rare HSIL cells on Pap tests, but they may be able to predict those women who are destined for cervical cancer without intervention. The intended goal is to accurately diagnose and avoid over treatment.

Publications

Rosenthal DL: Automation and the Endangered Future of the Pap Test (invited Commentary), JNCI 90:738-749, 1998.

ASCUS/LSIL Triage Study (ALTS)Group. Rosenthal DL, member of Pathology QC Group. Comparison of Three Management Strategies for Patients with Atypical Squamous Cells of Undetermined Significance: Baseline Results from a Randomized Trial. JNCI 93(4):293-299, 2001.

ASCUS/LSIL Triage Study (ALTS) Group. Rosenthal DL, member of Pathology QC Group. HPV DNA remains detectable longer than related cervical cytologic abnormalities. J Infect Dis 2002;186:1169-72.

Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical Squamous Cells of Undetermined Significance (ASC-US) in Liquid-Based Cytologic Specimens: Results of Reflex HPV Testing and Histologic Follow-up in Routine Practice with Comparison of Interpretive and Probablistic Reporting Methods. Cancer Cytopath 2003;99:191-7.

Trimble CL, Richards LA, Wilgus-Weigweiser B, Plowden K, Rosenthal DL, Klassen A. Effectiveness of Screening for Cervical Cancer in an Inpatient Hospital Setting. Obstet Gynecol. 2004;103:310-16.



 


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