|
Syed Z. Ali, M.B.B.S.
Primary Appointment in Pathology; Secondary Appointment in Radiology
Fine needle aspiration (FNA) has a widely recognized and established role as the initial diagnostic modality in most neoplastic and inflammatory disorders of the viscera and soft tissues. My major interest is focused on clinico-morphologic studies primarily based on FNA of breast, salivary glands, liver and soft tissues with integration of clinico-radiologic data and ancillary techniques such as immuno-cytochemistry and molecular genetics. These latter techniques not only augment our morphologic diagnoses in difficult cases, but often also provide important pathogenetic and prognostic information about these lesions. Digital photo imaging and telepathology is rapidly emerging as a major tool, not only in education and research, but also in diagnostic pathology. By utilizing state-of-the-art imaging equipment, I am involved in several on-going projects in this exciting new field ranging from web-based tutorials to sophisticated virtual photomicroscopy.
Publications
Kulesza P, Torbenson M, Sheth S, Erozan YS, Ali SZ. Cytopathologic grading of hepatocellular carcinoma on fine needle aspiration. Cancer 2004;102:247-258
Swierczynski SL, Lewis-Chambers S, Anderson JR, Keller JM, Hinkle DA, Ali SZ. Impact of liquid-based gynecologic cytology on a human immunodeficiency virus-positive population. Acta Cytol 2004;48:165-172
Ali SZ. Acinic cell carcinoma, papillary-cystic variant: A diagnostic dilemma in salivary gland aspiration. Diagn Cytopathol 2002;27:244-250
Steinberg DM, Chan TY, Freedman JA, Grimm LA, Ling L, Lehmann HP,Burroughs F, Rosenthal DL and Ali SZ. Teaching cytopathology to second-year medical students: An interactive, case-based approach. Acta. Cytol. 46(3)481-489, 2002.
Steinberg DM and Ali SZ. Application of virtual microscopy in clinical cytopathology. Diagn. Cytopathol. 25:389-396, 2001. |
|
| Email |
yerozan@jhmi.edu |
| Phone |
(410) 955-1180 |
|
|
Yener S. Erozan, M.D.
Primary Appointment in Pathology
My special areas of interest are pulmonary and gastro-intestinal cytopathology, and stereotactically guided biopsies of the brain. In addition to studying the morphology and evaluation of various preparation techniques, I am interested in correlating the light microscopy findings of cellular material with data obtained by other techniques (e.g., quantitative morphometry, ploidy analysis, immunocytochemistry, in situ hybridization polymerase chain reaction) and in the application of the latter in diagnostic cytopathology. I am currently collaborating with Dr. Melvyn Tockman in the investigation of cytopathologic, morphometric and antigenic characteristics of lung cancer during the developing stages.
Publications
Gaudin PB, Sherman ME, Brat DJ, Zahurak M, Erozan YS: Accuracy of gradinggliomas on CT-guided stereotactic biopsies: A survival analysis. DiagnCytopathol 17:461-466, 1997.
Tockman MS, Mulshine JL, Piantadosi S, Erozan YS, Gupta PK, Ruckdeschel JC, Taylor PR, Zhukov T, Zhou WH, Qiao YL, Yao S. For the Lung Cancer Early Detection Work Group Investigators and the Yunnan Tin Corporation Investigators: Prospective Detection of Preclinical Lung Cancer Results fromtwo studies of Heterogeneous Nuclear Ribonucleoprotein A2/B1 overexpression. Clin Cancer Res 3:2237-2246, 1997.
Qiao YL, Tockman MS, Li L, Erozan YS, Yao SX, Barrett MJ, Zhou WH,Giffen CA, Luo XC, Taylor PR. A case-cohort study of an early biomarker oflung cancer in a screening cohort of Yunnan Tin Miner in China. Cancer Epidemiology, Biomarkers and Prevention 6:893-900, 1997.
Li SQ, O'Leary TJ, Bukner SB, Przygodzki RM, Sobin LH, Erozan YS, Rosenthal DL. Fine needle aspiration of gastrointestinal stromal tumors(GIST) - Cytomorphology and immunocytochemistry. Acta Cytol 45:9-17, 2001. |
|
| Email |
mfraig1@jhmi.edu |
| Phone |
(410) 550-0669 |
|
|
Mostafa Fraig, M.D.
Primary Appointment in Pathology
My research is focused in the study of neoplastic and non neoplastic lung diseases. Pulmonary hypertension and acute lung injury are two areas where we study the underlying cellular interaction and role of different modulating factors in the histomorphologic changes noted in these diseases. Wide use of immunohistochemical staining to recognize and localize the effect of these factors in our animal models is an area where I make my contribution.
Clinicopathologic studies involving cases of interstitial lung disease to better define and understand these entities represent another area of interest.
Another area of expertise is in respiratory cytopathology and the use of guided FNA in the diagnosis and staging of lung cancer.
Publications
Fraig M., Shreesha U., Savici D., and Katzenstein A-L. Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers and never-smokers. Am J Surg Path, 2002, Vol. 26 (5); pp 647-653
Vincent BD., Fraig MM., and Silvestri GA. A pilot study of narrow-band imaging compared to white light bronchoscopy for evaluation of normal airways and premalignant and malignant airways disease. Chest, 131(6): 1794-1799, 2007
Moussa O., Riker M J., Klein J., Fraig MM., Halushka PV., and Watson D.K. Inhibition of Thromboxane Synthase activity modulate bladder cancer cell responses to chemotherapeutic agents. Oncogene (2008) 27, 55-62 published on line, July 2007
Garwood S., Judson M., Silvestri G., Fraig M. and Doelken P. Endobronchial ultrasound for the diagnosis of pulmonary sarcoidosis. Chest 131 (4):1298-304, 2007.
Watson PM., Miller SW., Fraig M., Cole DJ., Watson DK., and Boylan CaSm (LSm-1) over-expression in lung and mesothelioma is required for transformed phenotypes. Am J of Respir Cell Mol Biol, epublished in jan 2008. |
|
| Email |
qli23@jhmi.edu |
| Phone |
(410) 550-0669 |
|
|
Qing K Li, M.D., Ph.D.
Primary Appointment in Pathology
My main research interest is to apply the advanced technology of cellular and molecular biology to the field of cytopathology, particularly in the area of early detection of lung cancers. Currently, my research is focused on: (1) detection of circulating tumor cells in non-small cell lung cancer patients; (2) identifying what molecular markers and intracellular signal transduction pathways are involved, (3) and discovering novel molecular biomarkers with early diagnostic and prognostic significance.
Identification and utilization of these molecular markers not only augment our morphologic diagnoses in difficult cases, but also provide important pathogenetic and prognostic information of lung cancers.
Publications
Li Q, Subbulakshmi V, Oldfield C, Aamir R, Weyman CM, Wolfman A and Cathcart MK. Protein kinase C alpha regulates phosphorylation and enzymatic activity of cytosolic phospholipase A2 in vitro and in activated human monocytes. Cell Signal 2006. In press.
Li Q, Bavikatty N, and Michael CW. The role of Immunohistochemistry in the distinguishing squamous cell carcinoma from mesothelioma and adenocarcinoma in pleural effusion. Seminars of Diagnostic Pathol. 2006; 23:15.
Li Q, Murphy M, Ross JS, Sheehan C and Carlson JA. Skp2 and p27 kip1 expression in melanocytic nevi and melanoma: an inverse relationship. J. Cutan. Pathol. 2004; 31:633. |
|
| Email |
zmaleki1@jhmi.edu |
| Phone |
(410) 550-5220 |
|
|
Zahra Maleki, M.D.
Primary Appointment in Pathology
Temporary text
Publications
Temporary text |
|
|
Dorothy L. Rosenthal, M.D.
Primary Appointment in Pathology; Secondary Appointments in Oncology and Gynecology-Obstetrics
As a clinically-oriented cytopathologist, my research efforts are directed at answering diagnostic questions which are difficult or impossible when relying solely on morphologic features. Cervico-vaginal specimens (Pap smears) are perhaps the most challenging samples facing the cytologist. I have devoted much of my career to seeking ways to augment light microscopic diagnoses via computers. Neural networks combined with traditional image processing techniques have shown promise for automated scanning of slides. The ability of such systems to detect rare abnormal cells for human verification is currently being validated, but they promise to reduce the error rate of Pap Test interpretation. Our cytologists continue to be involved in the development of these devices. Identification of molecular markers to diagnose high grade pre-malignant lesions (HSIL) of the uterine cervix is an exciting collaborative effort with members of our division and with TriPath Oncology, a subsidiary of TriPath Imaging. Not only will the markers enable location of rare HSIL cells on Pap tests, but they may be able to predict those women who are destined for cervical cancer without intervention. The intended goal is to accurately diagnose and avoid over treatment.
Publications
Rosenthal DL: Automation and the Endangered Future of the Pap Test (invited Commentary), JNCI 90:738-749, 1998.
ASCUS/LSIL Triage Study (ALTS)Group. Rosenthal DL, member of Pathology QC Group. Comparison of Three Management Strategies for Patients with Atypical Squamous Cells of Undetermined Significance: Baseline Results from a Randomized Trial. JNCI 93(4):293-299, 2001.
ASCUS/LSIL Triage Study (ALTS) Group. Rosenthal DL, member of Pathology QC Group. HPV DNA remains detectable longer than related cervical cytologic abnormalities. J Infect Dis 2002;186:1169-72.
Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical Squamous Cells of Undetermined Significance (ASC-US) in Liquid-Based Cytologic Specimens: Results of Reflex HPV Testing and Histologic Follow-up in Routine Practice with Comparison of Interpretive and Probablistic Reporting Methods. Cancer Cytopath 2003;99:191-7.
Trimble CL, Richards LA, Wilgus-Weigweiser B, Plowden K, Rosenthal DL, Klassen A. Effectiveness of Screening for Cervical Cancer in an Inpatient Hospital Setting. Obstet Gynecol. 2004;103:310-16. |
|
|
