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Email ahamad@jhmi.edu
Phone (410) 614-3021

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Hamad Lab

Abdel Rahim A. Hamad, B.V.Sc., Ph.D.

Primary Appointment in Pathology, Secondary Appointment in Medicine
Member, Graduate Program in Immunology; Member, Graduate Program in Pathobiology

Dr. Hamad, a veterinarian and immunologist by training, received his Ph.D. in immunology at the laboratories of Dr. John Kappler at the National Jewish Center and postdoctoral training with Drs. Drew Pardoll and Jonathan Schneck at the Johns Hopkins University School of Medicine. Dr. Hamad’s independent research is focused on investigating the role of the Fas death pathway in regulating T cell homeostasis, self-tolerance and organ-specific autoimmunity. Dr. Hamad’s group is particularly interested in tacking the question of why inactivating the Fas pathway prevents organ specific autoimmunity and leads to accumulation of a peculiar T cell type that lack both CD4 and CD8 coreceptors (referred to as double negative, DN, T cells). Because the Fas pathway is not required for host defense, understanding how it regulates self-tolerance can lead to novel therapies that do not cause immunosuppression. Our focus is on type 1 diabetes (T1D), Ischemic renal injury (IRI) and autoimmune lymphoproliferative disease (ALPS) using both clinical and animal models in collaboration with physicians and scientists here at Hopkins and the NIH.

Hamad AR, Arcara K, Uddin S, Donner T. 2012. The potential of Fas ligand (apoptosis-inducing molecule) as an unconventional therapeutic target in type 1 diabetes, Frontiers in immunology, 3:196

Gutfreund, R., and A. R. Hamad. 2011. Immunotherapy for Type 1 Diabetes: Necessity, Challenges and Unconventional Opportunities. Book chapter in: Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy. D. Wager, ed. INTECH, Janeza Trdine 9. 409-424.

Xiao, X., Mohamood, A.S., Uddin, S., Gutfreund, R., Nakata, S., Marshall, A., Kimura, H., Caturegli, P., Womer, K.L., Huang, Y., J. Schneck, Hideo Yagita and Abdel Rahim A. Hamad. 2011. Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development. Am J Pathol. 179:725. PMID 21718680.

Ko, G.J., Jang, H.R., Huang, Y., Womer, K.L., Liu, M., Higbee, E., Xiao, Z., Yagita, H., Racusen, L., Hamad, A.R.A., and Rabb, H. 2011. Blocking fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury. J Am Soc Nephrol 22, 732-742. PMID: 21436290

Abdel Rahim Hamad. 2010. Analysis of gene profile, steady state proliferation and apoptosis of double negative T cells in the periphery and gut epithelium provides new insights into the biological functions of the Fas pathway. Immunol. Res. 47:134-42. PMID 20066510

Mohamood AS, Bargatze D, Xiao Z, Jie C, Yagita H, Ruben D, Watson J, Chakravarti S, Schneck JP, Hamad ARA. 2008. Fas-mediated apoptosis regulates the composition of peripheral alpha/beta T cell repertoire by constitutively purging out double negative T cells. PLoS ONE 3:e3465. PMID 18941614


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