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Email psimner1@jhmi.edu
Phone (410) 955-5077

Patricia J. Simner, Ph.D.

Primary Appointment in Pathology


My research interests include, 1) evaluating and developing novel diagnostic technologies for the detection of microorganisms from culture and direct from clinical specimens and 2) understanding the epidemiology, transmission, molecular resistance mechanisms, treatment, and prevention of multidrug-resistant pathogens, in particular β-lactamase-producing Gram-negative bacilli. My recent studies include 1) Elucidating an efficient workflow to screen for and confirm the presence of carbapenemase-producing Gram-negative bacilli in the clinical laboratory, 2) Evaluating the novel PCR-Electrospray Ionization Mass Spectrometry method for detection of yeasts from formalin-fixed, paraffin-embedded tissues, 3) Evaluating the novel PCR-Electrospray Ionization Mass Spectrometry method for detection of Mycobacterium species and Mycobacterium tuberculosis Complex Resistance Determinants, 4) Evaluating the novel PCR-Electrospray Ionization Mass Spectrometry method for detection and identification of fungi.

Publications
Simner PJ, H Adam, M Baxter, M McCraken, G. Golding, JA Karlowksy, K Nichol, P Lagacé-Wiens, MW Gilmour, Canadian Antimicrobial Resistance Alliance-CARA, DJ Hoban and GG Zhanel. 2015. Epidemiology of Vancomycin-Resistant Enterococci (VRE) in Canadian Hospitals: CANWARD 2007-2013. Submitted to Antimicrob. Agents Chemotherapy.

Simner PJ, MW Gilmour, P DeGagne, K Nichol and JA Karlowsky. 2014. Evaluation of Five Chromogenic Agar Media and the Rosco Rapid Carb Screen Kit for Detection and Confirmation of Carbapenemase Production in Gram-Negative Bacilli. J Clin Microbiol. 53:105-12.

Simner PJ, SP Buckwalter, JR Uhl, NL Wengenack and BS Pritt. 2013. Detection and Identification of Yeasts from Formalin-Fixed, Paraffin-Embedded Tissue Using PCR-Electrospray Ionization. J Clin Microbiol. 51:3731-4.

Simner PJ, SP Buckwalter, JR Uhl and NL Wengenack. 2013. Identification of Mycobacterium species and Mycobacterium tuberculosis Complex Resistance Determinants Using PCR-Electrospray Ionization Mass Spectrometry. J Clin Microbiol. 51:3492-8.

Simner PJ, JR Uhl, L Hall, MM Weber, RC Walkchak, S Buckwalter and NL Wengenack. 2013. Broad-Range Direct Detection and Identification of Fungi Using the PLEX-ID PCR-Electrospray Ionization Mass Spectrometry (ESI-MS) System. J Clin Microbiol. 51:1699-1706.



 


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