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Email avalsam1@jhmi.edu
Phone (410) 955-5077

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Molecular Diagnostics Laboratories


Alexandra Valsamakis, M.D., Ph.D.

Primary Appointment in Pathology; Joint Appointment in Molecular Medicine and Immunology (BSPH)
Member, Graduate Program in Molecular Microbiology and Immunology (BSPH)


My research is focused on the detection, identification, and therapeutic monitoring of infectious diseases, particularly viral infections. My current work entails 1) improving molecular assays that are critical for the management of hepatitis C and hepatitis B infections, 2) devising quantitative assays for viral infections and studying their clinical utility particularly in immunocompromised patients, and 3) investigation of the performance and utility of automated nucleic acid preparation instrumentation in the clinical laboratory. We utilize a variety of conventional (cell culture, antigen detection) and molecular techniques (nucleic acid amplification, primarily PCR and real time PCR).

Publications

Forman, M.S. and A. Valsamakis. Increased sensitivity of the Roche COBAS AMPLICOR HCV test v.2.0, using modified extraction techniques. J. Molec. Diag. 6:225-30, 2004.

Forman, M.S. and A. Valsamakis. Verification of an assay for quantification of HCV RNA using an analyte specific reagent and two different extraction methods. J. Clin. Micro. 42:3581-8, 2004.

Elbeik T, J Surtihadi, M Destree, J Gorlin, M Holodniy, S Jortani, K Kuramoto, V Ng, R Valdes, A Valsamakis, N Terrault. Multicenter evaluation of the performance characteristics of the Bayer VERSANT‘ HCV RNA 3.0 assay (bDNA). J. Clin. Micro. 42:563-9, 2004

Knepp, J.H., M.A. Geahr, M.S. Forman, and A. Valsamakis. Comparison of Automated and Manual Nucleic Acid Extraction Methods for the Detection of Enterovirus RNA. J. Clin. Microbiol. 41: 3532-3536, 2003.

Dumler, J.S. and A. Valsamakis. Molecular diagnostics of infectious diseases: complementary tools for a new era of clinical microbiology. Am J Clin Path 112: S33-S39, 1999.



 


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