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Email nparrish@jhmi.edu
Phone (410) 550-3525

Nicole M. Parrish, Ph.D.

Primary Appointment in Pathology

Tuberculosis continues to be the leading cause of death worldwide due to an infectious agent. Of greater concern in recent years, is the emergence of multi-drug resistance and the increasing incidence of infection with atypical mycobacteria in immunocompromised patients. These factors have highlighted the need for new antibiotics targeting these organisms. My primary research focus is aimed at characterization of the mechanism of action of a novel class of antimycobacterial compounds which have demonstrated potent in vitro efficacy against pathogenic mycobacteria, including multi-drug resistant strains. A variety of methods lead this approach including, proteomics, protein and lipid biochemistry as well as current molecular techniques.


Parrish, N.M., F.P. Kuhajda, H.S. Heine, W.R. Bishai, and J.D. Dick. 1999. Antimycobacterial activity of cerulenin and its effects on lipid biosynthesis. Journal of Antimicrobial Chemotherapy. 43: 219-226.

Jones, P.B., N.M. Parrish, T.A. Houston, A. Stapon, N.P. Bansal, J.D. Dick, and C.A.Townsend. 2000. A new class of antituberculosis agents. J. Med. Chem. 43(17): 3304-14.

Parrish, N.M, C. Townsend, P. Jones, T. Houston, and J. Dick. 2001. In vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis. Antimicrob. Agents Chemother. 45:1143-1150.

Parrish, N.M., C.A. Townsend, C.G. Ko, and J.D. Dick. 2004. Effect of n-Octanesulfonylacetamide (OSA) on ATP and protein expression in Mycobacterium bovis BCG. J. Antimicrob. Chemother. 54(4): 722-9.

Parrish, N.M., C.A. Townsend, C.G. Ko, and J.D. Dick. 2004. Congo red agar colony morphotypes and antibiotic susceptibility testing of M. avium subspecies paratuberculosis. 2004. Clinical Medicine and Research. 2: 107-114.


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