Edward W. Gabrielson, M.D.
Primary Appointment in Pathology; Secondary Appointment in Oncology
Member, Graduate Program in Environmental Health Sciences (BSPH)
The general goal of my research is to improve our understanding of the biology of cancer, particularly breast cancer and lung cancer. Our laboratory uses a variety of experimental approaches to study cancers, including gene expression arrays, mutational and chromosomal structural analysis, measurements of DNA methylation, and function assay of tumor cell growth. By characterizing genetic, epigenetic, and gene expression characteristics of cancers, we expect to be able to improve our ability to predict the clinical behavior, including prognosis and response to treatment, of specific tumors.
Gabrielson, E. Worldwide trends in lung cancer pathology. Respirology, 11: 533-538, 2006.
Garrett-Mayer, E., Parmigiani, G., Zhong, X., Cope, L., and Gabrielson, E. Cross-study validation and combined analysis of gene expression microarray data. Biostatistics, 2007.
Lee, J. S., Orita, H., Gabrielson, K., Alvey, S., Hagemann, R. L., Kuhajda, F. P., Gabrielson, E., and Pomper, M. G. FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer. Pharm Res, 24: 1202-1207, 2007.
Orita, H., Coulter, J., Lemmon, C., Tully, E., Vadlamudi, A., Medghalchi, S. M., Kuhajda, F. P., and Gabrielson, E. Selective inhibition of fatty acid synthase for lung cancer treatment. Clin Cancer Res, 13: 7139-7145, 2007.
Woo, J. H., Li, D., Wilsbach, K., Orita, H., Coulter, J., Tully, E., Kwon, T. K., Xu, S., and Gabrielson, E. Coix Seed Extract, a Commonly Used Treatment for Cancer in China, Inhibits NFkappaB and Protein Kinase C Signaling. Cancer Biol Ther, 6, 2007.