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Email frodrig4@jhmi.edu
Phone (443) 287-6646

Fausto J. Rodriguez, M.D.

Primary Appointment in Pathology; Secondary Appointment in Oncology


My clinical and research interests focus on the identification of diagnostic, prognostic, and therapeutic biomarkers in primary brain tumors. My current research activities aim to characterize molecular changes and signaling pathway alterations associated with the development of pediatric gliomas, as well as phenotypic characterization of murine models of CNS neoplasia. As part of a multidisciplinary effort, one of my main goals is to integrate classic histopathologic analyses with current ancillary and molecular data obtained through immunohistochemistry, microarray profiling, molecular cytogenetics, and genomic sequencing.

Publications

Rodriguez FJ, Gamez JD, Vrana JA, Theis JD, Giannini C, Scheithauer BW, Parisi J, Lucchinetti CF, Pendlebury WW, Dogan A. Immunoglobulin Derived Depositions in the Nervous System: Novel Mass Spectrometry Application for Protein characterization in Formalin-Fixed tissues. Lab Investig 2008;88:1024-37.

Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW, Anant S, Jenkins S, Eberhart CG, Sarkaria JN, Gutmann DH. Gene Expression Profiling of NF1-associated and Sporadic Pilocytic Astrocytoma Identifies ALDH1L1 as an Underexpressed Candidate Biomarker in Aggressive Astrocytoma Subtypes. J Neuropathol Exp Neurol 2008;12:1194-1204

Bender AM, Collier LS, Rodriguez FJ, Tieu C, Larson JD, Halder C, Mahlum E,. Kollmeyer TM, Akagi K, Sarkar G, Largaespada DL, Jenkins RB. Sleeping Beauty-mediated somatic mutagenesis implicates Csf1 in the formation of high grade astrocytomas. Cancer Res 2010; 70:3557-65.

Rodriguez EF, Scheithauer BW, Giannini C, Rynearson A, Cen L, Hoesley B, Gilmer-Flynn H, Sarkaria JN, Jenkins S, Long J, Rodriguez FJ. PI3K/AKT Pathway Alterations are Associated With Clinically Aggressive and Histologically Anaplastic Subsets of Pilocytic Astrocytoma. Acta Neuropathol 2011;121:407-20.

Rodriguez FJ, Orr B, Ligon K, Eberhart CG. Neoplastic cells are a rare component in human glioblastoma microvasculature. Oncotarget 2012;3:98-106.



 


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