Juan C. Troncoso, M.D.
Primary Appointment in Pathology; Secondary Appointment in Neurology
Member, Graduate Program in Pathobiology
Dr. Troncoso is Professor of Pathology and Neurology with Board-certifications in neurology and neuropathology. He received his M.D. from the Universidad Catolica de Chile, trained in clinical neurology at the Hahnemann Medical College and the Hospital of Philadelphia, and then in neuropathology at the Johns Hopkins School of Medicine. Dr. Troncoso directs a neuropathology research laboratory which is fully integrated with his service and teaching responsibilities.
The main research focus of the Troncoso laboratory is the pathology and neurobiology of age-associated neurological diseases, in particular the early and preclinical stages of Alzheimer’s disease. Dr. Troncoso directs the Neuropathology Cores for several NIH- and privately-funded research centers and studies at the Johns Hopkins University School of Medicine, including the Alzheimer’s Disease Research Center, the Udall Center for Excellence in Parkinson’s Research, the BIOCARD study, the Fronto-temporal Dementia Center, and the Baltimore Huntington’s Disease Center. A unique strength of Dr. Troncoso’s laboratory is the application of design-based stereology to the study of normal aging and neurodegenerative disorders both in humans and experimental animals.
Dr. Troncoso is also an expert in forensic neuropathology. He has been the neuropathology consultant to the Office of the Chief Medical Examiner for the State of Maryland since 1981. His experience in this field is collected in his book “Essential Forensic Neuropathology”, Lippincott Williams & Wilkins; 1st edition, 2009.
Research Funding. The Troncoso laboratory is funded from multiple sources that include NIA, NINDS, and private foundations. Dr. Troncoso is a recipient of a research grant from the BrightFocus Foundation entitled “Alzheimer’s Disease Pathology: before plaques and tangles”. This project focuses on degenerative neuropathology in subjects 30 to 50 years of age.
Teaching. Dr. Troncoso is a faculty member of the Pathobiology Graduate Program and is the director of the ACGME-accredited Fellowship training program in neuropathology. He is also PI of an R25 grant from NINDS that supports research training of neuropathology Fellows.
Dr. Troncoso is author of more than 250 publications. Below is a list of selected recent contributions:
Iacono D, Zandi P, Gross M, Markesbery W, Pletnikova O, Rudow G, Troncoso J. APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study. Oncotarget. 2015;6 (16):14082-91. PMCID: PMC4546453
Nucifora FC Jr, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, Dawson TM, Smith W, Lim KL, Ross CA. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nat Commun. 2016;7:11792. PMCID:PMC4899630
Pletnikova O, Rudow GL, Hyde TM, Kleinman JE, Ali SZ, Bharadwaj R, Gangadeen S, Crain BJ, Fowler DR, Rubio AI, Troncoso JC. Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age. Cogn Behav Neurol. 2015 Sep;28 (3):144-52. PMCID:PMC4588069
Bañez-Coronel M, Ayhan F, Tarabochia AD, Zu T, Perez BA, Tusi SK, Pletnikova O, Borchelt DR, Ross CA, Margolis RL, Yachnis AT, Troncoso JC, Ranum LP. RAN Translation in Huntington Disease. Neuron. 2015;88(4):667-77. PMCID:PMC4684947
Ling JP, Pletnikova O, Troncoso JC, Wong PC. NEURODEGENERATION. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science. 2015;349(6248):650-5. PMCID: PMC4825810