< Brochure Homepage | Faculty Index | Pathology Homepage



Email koliat@jhmi.edu
Phone (410) 502-5172

Related Websites
Koliatsos Laboratory

Traumatic Brain Injury Research Center


Vassilis E. Koliatsos, M.D.

Primary Appointment in Pathology; Secondary Appointments in Neurology, Neuroscience, Psychiatry
Member, Graduate Program in Neuroscience; Member, Graduate Program in Pathobiology


Vassilis E. Koliatsos, MD, MBA is Professor of Pathology (Neuropathology) and Neurology and Associate Professor of Psychiatry and Behavioral Sciences. His main research interest is neural responses to traumatic and degenerative insults and mechanisms of neural repair and has close to 100 publications in this area. He has characterized a number of nourishing peptide chemicals (“neurotrophic factors”) for key populations of neurons in the brain and his stem cell work in animal models of disease has recently entered the first clinical trial of cellular therapy for a major neurodegenerative disorder (ALS). He has mentored numerous pre- and post-doctoral students and has taught residents in neurology and psychiatry on basic and clinical neurosciences.

Dr. Koliatsos' present emphasis is on Traumatic Brain Injury (TBI), especially the role of axonopathy in mechanisms associated with chronic TBI such as disconnection and its transsynaptic effects, neuroinflammation, and proteinopathy (tauopathy, amyloidosis). In parallel, he does research on the use of stem cells as cellular therapies for TBI. He also explores the use of induced pluripotent stem cells as in vitro models (cell cultures, cerebral organoids) of human neurological and neuropsychiatric illness.

Dr. Koliatsos serves on the faculty of the Ph.D. graduate program of Pathobiology of Disease and has also served in the Ph.D. Neuroscience program. Dr. Koliatsos also leads the Traumatic Brain Injury Research Center in the Department of Pathology and sees patients with traumatic brain injury and degenerative dementias. Dr. Koliatsos has been awarded the Leadership and Excellence in Alzheimer’s disease Award and the Javits Neuroscience Investigator Award, both from NIH.

Publications

Xu L, Ryu J, Hiel H, Menon A, Aggarwal A, Rha E, Mahairaki V, Cummings BJ, Koliatsos VE: Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation. Stem Cell Research and Therapy, in press

Sisniega A, Zbijewski W, Xu J, Dang H, Stayman J, Yorkston J, Aygun N, Koliatsos VE, Siewerdsen JH: High-fidelity artifact correction for cone-beam CT imaging of the brain. Physics in Medicine and Biology 60(4):1415-39, 2015.

Ryu J, Horkayne I, Plenticova O, Xu, L, Eberhart CG, Troncoso JC and Koliatsos VE: The problem of axonal injury in the brains of veterans with histories of blast exposure. Acta Neuropathol Commun. 2(1) 153; Nov 25, 2014.

Xu L, Nguyen J, Lehar M, Menon A, Rha E, Arena J, Ryu J, Marmarou C, Marsh-Armstrong N and Koliatsos VE: A mouse model of repeat mild traumatic brain injury: selective multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system. Exp Neurol. pii: S0014-4886(14)00364-1. 2014.

Mahairaki V, Ryu J., Peters A, Park TS, Burridge PW, Zambidis ET and Koliatsos VE: Transgene-free familial Alzheimer’s disease-derived iPSCs differentiate into mature neurons with pathogenic properties. Stem Cells Dev., 2014 Aug 21. [Epub ahead of print]

Rossi SL, Mahairaki V, Zhou L, Song Y, Koliatsos VE: Remodeling of piriform cortex after lesions in adult rodents. Neuroreport, 25(13):1006-1012, 2014.

Koliatsos VE, Cernak I, Xu L, Song Y, Savonenko A, Crain B, Eberhart CG, Frangakis CE, Melnikova T, Kim H, Lee D: A mouse model of blast injury to brain: initial pathological, neuropathological and behavioral characterization. J. Neuropathol. Exp. Neurol., 70(5):399-416, 2011.

Cernak I, Merkle AC, Koliatsos VE, Bilik J, Luong Q, Mahota T, Xu L, Slack N, Windle D and Ahmed FA: The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice. Neurobiol. Dis., 41(2):538-51, 2011.

Nasonkin I, Mahairaki V, Xu L, Hatfield G, Cummings B, Eberhart C, Ryugo DK and Koliatsos VE: Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum. Stem Cells, 27(10): 2414-26, 2009.

Yan J, Xu L, Welsh AM, Hatfield G, Hazel T, Johe K, Koliatsos VE. Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord. PLoS Medicine, 4(2):318-332, 2007.

Xu L, Yan J, Chen D, Welsh AM , Hazel T, Johe K, Hatfield G , Koliatsos VE: Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats. Transplantation, 82(7):865-875, 2006.



 


Copyright © 2017 Johns Hopkins University. All Rights Reserved