Aaron A. R. Tobian, M.D., Ph.D.
Primary Appointment in Pathology
Secondary Appointment in Medicine and Epidemiology
Member, Graduate Program in Pathobiology
My research is focused in two main areas associated with transfusion. 1) We are evaluating the biological mechanisms of adverse events associated with platelet transfusions, methods to prevent these reactions, and the appropriate settings for transfusions. 2) I collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, and have established a research program evaluating the epidemiologic risk factors of HIV and other sexually transmitted infections. Working closely with the RHSP, we are evaluating the efficacy of male circumcision to prevent sexually transmitted infections in men and their female partners. In addition, using foreskin mucosal tissue, we are assessing the genital cellular immune milieu associated with sexually transmitted infections to develop novel HIV prevention therapies.
Tobian AAR, Savage WJ, Tisch DJ, Thoman S, King KE, and Ness PM. Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduction. Transfusion. 2011; 51: 1676-1683.
Goel R, Ness PM, Takemoto C, King KE, Krishnamurti L, and Tobian AAR. Platelet transfusions in platelet consumptive disorders are associated with in-hospital arterial thrombotic complications and mortality. Blood. 2015; 125(9):1470-1476.
Kaufman RM, Djulbegovic B, Gernsheimer T, Kleinman S, Tinmouth AT, Capocelli KE, Cipolle MD, Cohn CS, Fung MK, Grossman BJ, Mintz PD, O’Malley BA, Sesok-Pizzini DA, Shander A, Stack GE, Webert KE, Weinstein R, Welch BG, Whitman GJ, Wong EC, and Tobian AAR. Platelet transfusion: a clinical practice guideline from the AABB. Annals of Internal Medicine. 2015; 162:205-213.
HIV and sexually transmitted infections:
Tobian AAR, Serwadda D, Quinn TC, Kigozi G, Gravitt PE, Laeyendecker O, Charvat B, Ssempijja V, Riesdel M, Oliver AE, Nowak RG, Moulton LH, Chen MZ, Reynolds SJ, Wawer MJ, Gray RH. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med 2009; 360:1298-309.
Tobian AAR and Gray RH. The medical benefits of male circumcision. JAMA. 2011; 306: 1479-1480.
Tobian AAR, Kigozi G, Manucci J, Grabowski MK, Serwadda D, Musoke R, Redd AD, Nalugoda F, Reynolds SJ, Kighoma N, Laeyendecker O, Lessler J, Gray RH, Quinn TC, Wawer MJ and the Rakai Health Sciences Program. HIV shedding from male circumcision wounds in HIV-infected men: a prospective cohort study. PLoS Medicine. 2015; 12(4): e1001820.
Grabowski MK, Gray RH, Makumbi F, Kagaayi J, Redd AD, Kigozi G, Reynolds SJ, Nalugoda F, Lutalo T, Wawer MJ, Serwadda D, Quinn TC, Tobian AAR. Use of injectable hormonal contraception and women’s risk for herpes simplex virus type 2 acquisition: a prospective study of couples in Rakai, Uganda. Lancet Global Health. 2015; 3:e478-86.