Patricia Brunker, M.D., Ph.D.
Primary Appointment in Pathology
Molecular hematology testing was initiated in 2009 at the Johns Hopkins Hospital as an outgrowth of the reference serology lab. Particularly in cases of complicated alloimmunization, such as that found in sickle cell disease, or in warm autoimmune hemolytic anemia, molecular characterization of patients and/or blood products has informed an even more patient-centered and individualized approach to transfusion medicine practice since its inception. Projects in this area include increased utilization and outcomes research in molecular testing, including weak and partial Rh testing, cell-free, fetal DNA, and real-time PCR. Our projects to understand genetics of the basis of alloimmunization include the evaluation of rapid-responder and non-responder status in pregnancy and family studies of alloimmunization including microchimerism analysis.
Brunker, P. A. (2013). Chimerism in transfusion medicine. Chimerism, 4(4).
Brunker, P. A., & Flegel, W. A. (2011). Scianna: the lucky 13th blood group system. Immunohematology/American Red Cross, 27(2), 41.
Leider, J. P., Brunker, P. A., & Ness, P. M. (2010). Convalescent transfusion for pandemic influenza: preparing blood banks for a new plasma product?. Transfusion, 50(6), 1384-1398.
Ramaley, P. A., French, N., Kaleebu, P., Gilks, C., Whitworth, J., & Hill, A. V. (2002). HIV in Africa: chemokine-receptor genes and AIDS risk. Nature, 417(6885), 140-140.
Hellier, S., Frodsham, A. J., Hennig, B. J., Klenerman, P., Knapp, S., Ramaley, P., ... & Hill, A. V. (2003). Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP‐2, with outcome of HCV infection. Hepatology, 38(6), 1468-1476.