Paul M. Ness, M.D.
Director, Division of Transfusion Medicine
Primary Appointment in Pathology; Secondary Appointments in Medicine, Oncology
Our laboratory has a long standing interest in development of assays for detecting red cell antibodies and small populations of heterogeneous red cells using a quantitative enzyme-linked antiglobulin test. This assay has proved useful in the study of fetal-maternal hemorrhage, red cell survival studies, and autoimmune hemolytic anemia. We are also studying Rh immunization in pregnancy taking advantage of molecular testing methods for blood grouping. Ongoing clinical studies in transfusion medicine include the use of blood components in trauma and cardiac surgery, the effects of the age of stored red cells and methods to reduce these defects, clinical investigations of pathogen reduced blood components, multiple studies on transfusion reduction in patient blood management settings, the development and use of hemoglobin-based oxygen carriers as blood substitutes, and several projects on international blood safety including HIV and hepatitis reduction and blood utilization patterns in China.
Steiner ME, Ness PM, Assman SF, Triulzi DJ, Sloan DR, Delaney M, Granger S, Bennett-Guerrero E, Blachman MA, Scavo V, Carson JL, Levy JH, Whitman G, D'Andra P, Pulkrabek S, Ortel TL, Bornikova L, Raife T, Puca KE, Kaufman RM, Nuttall GA, Young PP, Youssef S, Engelman R, Greilich PE, Miles R, Josephson CD, Bracey A, Cooke R, McCullough, J, Hunsaker R, Uhl L, McFarland JG, Park Y, Cushing MM, Klodell CT, Karanam R, Roberts PR, Dyke C, Hod EA, Stowell CP. Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med 372:1419-29, 2015.
Frank, S. M., Rothschild, J. A., Masear, C. G., Rivers, R. J., Merritt, W. T., Savage, W. J., & Ness, P. M. Optimizing preoperative blood ordering with data acquired from an anesthesia information management system. , Anesthesiology 118(6), 1286-1297, 2013
Savage WJ, Tobian AAR, Savage JH, Hamilton RG, Ness PM. Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets. Transfusion 51; 2337-2342, 2011.
Anderson KC, Ness PM. Scientific basis of transfusion medicine: Implications for clinical practice. Second Edition, WB Saunders, Philadelphia PA 1999.