Charles J. Steenbergen, M.D., Ph.D.
Primary Appointment in Pathology
My research is on mechanisms of ischemic heart disease, and in particular, endogenous mechanisms that can be activated to protect the heart during episodes of ischemia and reperfusion. I am interested in identifying signal transduction pathways that are involved in cardioprotection, and understanding how these signaling pathways confer their protective effect. Recently, we have become interested in how microRNA can regulate mitochondrial protein synthesis and alter mitochondrial function, and we have worked on novel methods for measuring S-nitrosylation, a form of post-translational protein modification that is important in heart disease, and is usually cardioprotective. We hope that better understanding of these mechanisms will lead to the development of better therapies for patients with coronary artery disease, heart failure, and patients undergoing heart surgery.
Murphy, E. and Steenbergen, C.: Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol. Rev. 2008; 88: 581-609.
Das, S., Ferlito, M., Kent, O.A., Fox-Talbot, K., Wang, R., Liu, D., Raghavachari, N., Yang, Y., Wheelan, S.J., Murphy, E., Steenbergen, C. Nuclear miRNA regulates the mitochondrial genome in the heart. Circ. Res. 2012; 110: 1596-1603.
Yano, T., Ferlito, M., Aponte, A., Kuno, A., Miura, T., Murphy, E., Steenbergen, C. Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling. Circ. Res. 2014; 114: 1268-1280.
Kohr, M.J., Murphy, E., Steenbergen, C. Glyceraldehyde-3-phosphate dehydrogenase acts as a mitochondrial trans-S-nitrosylase in the heart. PLoS One. 2014; 9: e111448.
Sun, J., Nguyen, T., Aponte, A.M., Menazza, S., Kohr, M.J., Roth, D. M. Patel, H.H., Murphy, E., Steenbergen, C. Ischemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc. Res. 2015; 106: 227-236.