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Email wclarke@jhmi.edu
Phone (410) 502-7692

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William Clarke, Ph.D.

Primary Appointment in Pathology
Member, Graduate Program in Biochemistry, Cellular and Molecular Biology

My research interests primarily involve the development of analytical methods for drug analysis. This includes the development and implementation of tandem mass spectrometry and high resolution-accurate mass (HRAM) mass spectrometry method for measurement of multiple drugs in a single sample, as well as investigation of alternative matrices for drug testing. In addition, I am interested in the application of pharmacokinetic measurements, along with pharmacogenetic testing, to clinical management of patients. Active projects in our lab include pharmacokinetic monitoring of antidepressants and mood-stabilizing drugs in bariatric surgery patients, pharmacokinetic evaluation of antidepressant drugs in pregnant women with mood disorders, and qualitative screening for antiretroviral drugs and substances of abuse in various HIV Prevention Clinical Trials. We are also investigating ways to improve the robustness and throughput of LC-MS methods in the clinical laboratory by evaluation of newly developed technologies and alternative approaches to LC-MS method development.

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