My main research interest is to apply the advanced technology of cellular and molecular biology to the field of cytopathology, particularly in the area of early detection of lung cancers. Currently, my research is focused on: (1) detection of circulating tumor cells in non-small cell lung cancer patients; (2) identifying what molecular markers and intracellular signal transduction pathways are involved, (3) and discovering novel molecular biomarkers with early diagnostic and prognostic significance.
Identification and utilization of these molecular markers not only augment our morphologic diagnoses in difficult cases, but also provide important pathogenetic and prognostic information of lung cancers.
Li Q, Subbulakshmi V, Oldfield C, Aamir R, Weyman CM, Wolfman A and Cathcart MK. Protein kinase C alpha regulates phosphorylation and enzymatic activity of cytosolic phospholipase A2 in vitro and in activated human monocytes. Cell Signal 2006. In press.
Li Q, Bavikatty N, and Michael CW. The role of Immunohistochemistry in the distinguishing squamous cell carcinoma from mesothelioma and adenocarcinoma in pleural effusion. Seminars of Diagnostic Pathol. 2006; 23:15.
Li Q, Murphy M, Ross JS, Sheehan C and Carlson JA. Skp2 and p27 kip1 expression in melanocytic nevi and melanoma: an inverse relationship. J. Cutan. Pathol. 2004; 31:633.