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Email skern1@jhmi.edu
Phone (410) 614-3314

Scott E. Kern, M.D.

Primary Appointment in Oncology; Secondary Appointment in Pathology
Member, Graduate Program in Human Genetics and Molecular Biology; Member, Graduate Program in Pathobiology


I am a cancer geneticist and gastrointestinal pathologist interested in clonal genetic changes in neoplasia. This has included genetic alterations in colorectal and pancreatic carcinoma, their association with pathological characteristics and prognosis, cloning of the DCC and DPC4 genes, localization of the BRCA2 gene, identifying the causes of familial pancreatic cancer, the DNA-binding characteristics of p53 and DPC4, the functional basis of cancer biomarkers, and the principles of genotype-specific anticancer therapy.

Publications

Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B.Identification of p53 as a sequence-specific DNA-binding protein. Science 252:1708-11, 1991.

Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, da Costa LT, Rozenblum E,Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. DPC4, a candidate tumor-suppressor gene at human chromosome 18q21.1. Science 271:350-353,1996.

Brody JR, Calhoun ES, Gallmeier E, and Kern SE. Ultra-fast, high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media. BioTechniques 2004; 37:598-602.

Hucl T, Rago C, Gorospe M, Kern SE. A syngeneic variance library for functional annotation of human genetic variation: Application to BRCA2 exon 27. Cancer Res 2008; 68:5023-30

Ren RY, Patel K, Paun BC, Kern SE. Structural analysis of the cancer-specific mesothelin promoter/enhancer sequences. JBC 2011; 286:11960-9.



 


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