Laura Wood, M.D., Ph.D.
Primary Appointment in Pathology
My laboratory focuses on genomic and morphological characterization of pancreatic and liver neoplasms. Decades of cancer research have shown that cancer is a genetic disease caused by somatic mutations in oncogenes and tumor suppressor genes. With rapid advances in sequencing and bioinformatics technology, whole exome or even whole genome sequencing studies of tumors can now be routinely performed. However, the next key step is utilizing these technologies to address specific clinically relevant questions about cancer genomes. My laboratory focuses on two such clinically relevant issues: (1) the transition from non-invasive precursor lesions to invasive cancer and (2) intratumoral heterogeneity. We investigate these questions with cutting-edge genomic approaches, including genetic analyses of single cells. In addition, in collaboration with Dr. Denis Wirtz in the School of Engineering, we also perform high-throughput phenotyping analyses of human tumors. The goal of these studies is to characterize the phenotypic determinants of invasion and heterogeneity as well as correlate tumor genotype and phenotype on the single cell level.
Sjöblom T*, Jones S*, Wood LD*, Parsons DW*, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13; 314(5797):268-74.
Wood LD*, Parsons DW*, Jones S*, Lin J*, Sjöblom T*, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JKV, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PVK, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B. The genomic landscapes of human breast and colorectal cancers. Science. 2007 Nov 16; 318(5853):1108-13.
Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, Papadopoulos N, Cai J, Torbenson MS, Kinzler KW. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet. 2011 Aug 7; 43(9):828-9.
Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, Eshleman JR, Goggins MG, Wolfgang CL, Canto MI, Schulick RD, Edil BH, Choti MA, Adsay V, Klimstra DS, Offerhaus GJ, Klein AP, Kopelovich L, Carter H, Karchin R, Allen PJ, Schmidt CM, Naito Y, Diaz LA Jr, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci USA. 2011 Dec 27; 108(52):21188-93.
Wood LD, Heaphy CM, Daniel HJ, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove D, Boitnott J, Meeker AK, Torbenson M. Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphologic and molecular features. Mod Pathol. 2013 May. Epub ahead of print.