Tamara Lotan, M.D.
Primary Appointment in Pathology; Secondary Appointment in Oncology
I am a urologic pathologist with a research laboratory focused on the role of PTEN/PI3K/mTOR signaling in epithelial development and tumorigenesis. My basic science lab works with a number of epithelial systems (prostate, breast, skin) and we are principally interested in understanding how these oncogenic signaling pathways regulate epithelial differentiation, apico-basal polarity and cell migration. Using transgenic mouse models combined with 3D culture and state-of-the-art live cell imaging techniques, our hope is that by understanding the role of this signal transduction network in epithelial embryonic development, we can help to elucidate the significance of these oncogenic signals during tumorigenesis and tumor progression.
The more translational arm of my laboratory effort is focused on validating PTEN as a potential predictive and prognostic biomarker in prostate cancer, and on defining alternative mechanisms of PTEN inactivation in prostate cancer. We also have an ongoing interest in the molecular phenotype of rare subtypes of prostate cancer, including small cell carcinoma, p63-positive prostatic carcinoma and intraductal prostatic carcinoma.
Lotan TL, Wang W,Gupta NS, Toubaji A, Haffner MC, Meeker AK, De Marzo AM, Epstein JI, and Netto GJ. ERG Gene Rearrangements are Common in Prostatic Small Cell Carcinoma. Modern Pathology. 2011; 24(6):820-8.
Lotan TL, Gurel B, Sutcliffe S, Esopi D, Liu W, Xu J, Hicks JL, Park BH, Humphreys E, Partin AW, Han M, Netto GJ, Isaacs WB, De Marzo AM. PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients. Clinical Cancer Research. 2011; 17(20):6563-73.
Ghosh S, Lau H, Simons BW, Powell JD, Meyers DJ, De Marzo AM, Berman DM, Lotan TL. PI3K/mTOR Signaling Regulates Prostatic Branching Morphogenesis. Developmental Biology. 2011; 360(2):329-42.