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Email ljarend@jhu.edu
Phone (443) 287-0166

Lois J. Arend, M.D., Ph.D.

Primary Appointment in Pathology


My laboratory studies the mechanisms of mammalian kidney development. Specifically, our studies involve various cell and molecular biology techniques to determine the role of the bioactive sphingolipid, sphingosine-1-phosphate (S1P), in organogenesis of the kidney. Our research indicates that S1P may be involved in development of conditions such as cystic kidney disease and Meckel syndrome. We also study the pathologic aspects of other kidney disease by various morphologic techniques, including light, immunofluorescence, and electron microscopy.

Publications
Arend LJ, Smart AM, and JP Briggs. Metanephric rat-mouse chimeras to study cell lineage of the nephron. Developmental Genetics 24(3/4):230-240, 1999

Arend LJ, Smart A, and JP Briggs. Mouse beta 6 integrin sequence, pattern of expression, and role in kidney development. J Am Soc Nephrol 11:2297-2305, 2000

Phillips CL, Arend LJ, Filson A, Kojetin D, Clendenon J, Fang S, and KW Dunn. Three dimensional imaging of embryonic mouse kidney by two-photon microscopy. Am J Pathol 158(1):49-55, 2001

Fu J, Jin Y, and LJ Arend. Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of XIAP. J Biol Chem Dec 26;278(52):52660-72, 2003

Lorenz, JN, L.J. Arend, R Robitz, RJ Paul, AJ MacLennan. Vascular dysfunction in S1P2 sphingosine-1-phosphate receptor knockout mice. American Journal of Physiology- Regulatory, Integrative and Comparative Physiol 292(1):R440-6, 2007

Kirby RJ, Jin Y, Fu J, Cubillos J, Swertfeger, D, Arend LJ. Dynamic regulation of sphingosine-1-phosphate homeostasis is critical for branching morphogenesis of the mouse metanephric kidney. Am J Physiol Renal Physiol 296:F634-F641, 2009

Kirby RJ, Swertfeger, D, Arend LJ. Crosstalk between GDNF/RET and S1P/S1PR signaling pathways regulates kidney epithelial cell migration. In Preparation.



 


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