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Email tlw@jhmi.edu
Phone (410) 502-0863

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Ovarian Cancer Prevention

Sidney Kimmel Ovarian Cancer Center


Tian-Li Wang, Ph.D.


Dr. Tian-Li Wang is a Professor in the Departments of Pathology, Oncology, and Gynecology & Obstetrics at the Johns Hopkins School of Medicine. She is also a faculty member of the Pathobiology Graduate Program. Dr. Wang co-directs the Biorepository Bank of Gynecologic Malignancies and co-leads the Molecular Genetics Laboratory of Female Reproductive Cancer at Johns Hopkins.

Dr. Wang earned her undergraduate degree at National Taiwan University. She completed a Ph.D. at the Johns Hopkins University School of Medicine. Then in 2004, she joined the faculty at the Johns Hopkins Departments of Gynecology/Obstetrics and Oncology and established her research team. She went on to join the Department of Pathology in 2014.

Dr. Wang's research interest is to elucidate the molecular pathogenesis of gynecologic malignancies, with a special focus on tumor recurrence, tumor evolution and the development of preventive and therapeutic strategies. She has applied functional genomic and proteomic technologies to identify genetic and protein markers in ovarian and uterine carcinomas. The novel cancer-associated genes identified by her team include NOTCH3, SYK, ARID1A, PPP2R1A, and PBX1. Her research is supported by several NCI/NIH and DoD grants, as well as private foundations, including the Ovarian Cancer Research Fund. Dr. Wang is also an investigator in the DoD-sponsored Ovarian Cancer Consortium, which aims at identifying and characterizing early molecular alterations in the genesis of ovarian cancer.

Publications

Stoeck A, Jung J, Guan B, Wu R-C, Zhu H, Blackshaw S, Shih Ie, Wang TL. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. Plos Genetics . Oct 30;10(10):e1004751. PMID: 25356737

Yusuke Kobayashi, Hiroyasu Kashima, Ren-Chin Wu, Jin- Gyoung Jung, Jen-Chun Kuan, Jinghua Gu, Jianhua Xuan, Lori Sokoll, Kala Visvanathan, Ie-Ming Shih, Wang TL. Mevalonate Pathway Antagonist Inhibits Proliferation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models. Clinical Cancer Research, 2015 Jun 24 PMID: 26109099 [Epub ahead of print]. PMID: 26109099

Wu RC, Ayhan A, Maeda D, Kim KR, Clarke BA, Shaw P, Herman Chui M, Rosen B, Shih IM, Wang TL. Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynecologic malignancies. J Pathol. 2014 Mar; 232(4):473-81. PMID: 24338723

Yuyu Fun, et al, Wang TL* and Shih IeM. Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell, Jul 13;28(1):82-96. PMID: 26096845 *Corresponding author

Guan B, Suryo Rahmanto Y, Wu RC, Wang Y, Wang Z, Wang TL, Shih IeM. Roles of deletion of arid1a, a tumor suppressor, in mouse ovarian tumorigenesis. J Natl Cancer Inst. 2014 Jun 4;106(7). PMID: 24899687 * Co-corresponding author



 


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