Chien-Fu Hung, Ph.D.
Primary Appointment in Pathology
Cervical cancer and ovarian cancer represent two major issues in women’s health. Cervical cancer is the second most deadly form of cancer in women worldwide, while ovarian cancer is the most deadly gynecologic malignancy. My research centers primarily on developing immmunotherapeutic vaccination strategies for the prevention and treatment of cervical and ovarian cancers. Our lab has developed several strategies to enhance immunologic responses against cancers. Some of these strategies involve targeting an antigen into dendritic cells, targeting an antigen into MHC class I and II processing pathways, enhancing intercellular spreading of antigen, and combining antigen-specific immunotherapy and antiangiogenesis.
Recently, we have been focusing on developing innovative immunotherapeutic strategies against ovarian cancer. The efficacy of immunotherapies and vaccines against ovarian cancer are often compromised by pre-existing immune tolerance against endogenous antigens. To this end, we have been developing therapeutic agents that are capable of coating foreign antigenic peptides onto ovarian tumor cells, which render the tumor cells susceptible to killing by foreign antigen-specific CD8+ T cells. Our novel technologies have important implications in circumventing immune tolerance to enhance cancer immunotherapies.
Chang, C. L., Hsu, Y. T., Wu, C. C., Yang, Y. C., Wang, C., Wu, T. C., and Hung, C. F. (2012) Immune mechanism of the antitumor effects generated by bortezomib. J Immunol 189, 3209-3220.
Chang, C. L., Hsu, Y. T., Wu, C. C., Lai, Y. Z., Wang, C., Yang, Y. C., Wu, T. C., and Hung, C. F. (2013) Dose-dense chemotherapy improves mechanisms of antitumor immune response. Cancer Res 73, 119-127.
Kang, T. H., Ma, B., Wang, C., Wu, T. C., and Hung, C. F. (2013) Targeted coating with antigenic peptide renders tumor cells susceptible to CD8(+) T cell-mediated killing. Mol Ther 21, 542-553.
Soong, R. S., Song, L., Trieu, J., Knoff, J., He, L., Tsai, Y. C., Huh, W., Chang, Y. N., Cheng, W. F., Roden, R. B., Wu, T. C., Trimble, C. L., and Hung, C. F. (2014) Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNgamma. Clin Cancer Res 20, 5456-5467.
Lee, S. J., Song, L., Yang, M. C., Mao, C. P., Yang, B., Yang, A., Jeang, J., Peng, S., Wu, T. C., and Hung, C. F. (2015) Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation. Vaccine 33, 1549-1555.