Michael J. Borowitz, M.D., Ph.D.
Deputy Director for Education
Deputy Director for Clinical Affairs
Director, Division of Hematologic Pathology
Primary Appointment in Pathology; Secondary Appointment in Oncology
My research focuses on defining the complexity of hematologic neoplasms. I am particularly interested in the immunologic aspects of leukemia and lymphoma, and in the relation of phenotypic variability to clinical and biological heterogeneity in these diseases. I employ routine morphologic techniques and immunocytochemistry in my investigations, but I am particularly interested in flow cytometry. A major focus of my efforts has been in childhood acute lymphocytic leukemia, in conjunction with investigators in the Children's Oncology Group, where I am specifically interested in studies of minimal residual disease, as detected by flow cytometry, and its effect on prognosis. I am also interested in developing new clinical applications of flow cytometry, particularly as it applies to blood and bone marrow.
Borowitz MJ, Pullen DJ, Shuster JJ, Viswanatha D, Montgomery K, Willman CL, Camitta B. (2003) Minimal residual disease detection in childhood precursor–B-cell acute lymphoblastic leukemia: Relation to other risk factors. A Children’s Oncology Group Study Leukemia 17:1566-1572
Weir EG, Cowan K, LeBeau P, Borowitz MJ. (1999) A limited antibody panel can distinguish B-precursor acute lymphoblastic leukemia from normal B-precursors with four color flow cytometry: implications for residual disease detection. Leukemia 13:558-567.
Nicol TL, Silberman M, Rosenthal DL, Borowitz MJ. (2000) The accuracy of combined cytopathologic and flow cytometric analysis of fine-needleaspirates of lymph nodes. Am J Clin Pathol; 114:18-28.
Brodsky RA, Mukhina GL, Li S, Nelson KL, Chiurazzi PL, Buckley JT, Borowitz MJ. (2000) Improved detection and characterization of paroxysmalnocturnal hemoglobinuria using fluorescent aerolysin. AM J Clin Pathol 114:459-466.