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Email aduffie1@jhmi.edu
Phone (410) 955-3580

Amy S. Duffield, M.D., Ph.D.

Assistant Professor of Pathology

Many patients with acute myeloid leukemia have tumor cells that express mutant FMS-Like tyrosine kinase 3 (FLT3). The mutant protein often carries activating mutations, and patients with these activating mutations have a particularly poor prognosis. FLT3 is a promising therapeutic target; however, FLT3 inhibitors have consistently shown disappointing results in clinical trials. I work with Donald Small's laboratory (Pediatric Oncology) to characterize novel FLT3 interactors in order to identify mechanisms that could enhance the efficacy of existing FLT3 inhibitors and uncover new drug targets.



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