Molecular Genetics of Female Reproductive Cancer Lab



Ie-Ming Shih, MD, PhD

Ie-Ming Shih, MD, PhD

Dr. Shih is a Professor of Pathology, Gynecology/Obstetrics and Oncology at the Johns Hopkins University School of Medicine, Baltimore, Maryland. He is a board-certified attending pathologist in the Division of Gynecologic Pathology at the Johns Hopkins Hospital. Dr. Shih obtained his MD degree from the Taipei Medical University, Taiwan in 1988, and received his PhD in biomedical studies at the University of Pennsylvania in 1993. He completed residency training in Anatomic Pathology followed by a Gynecologic Pathology fellowship at the Johns Hopkins Hospital. He spent two post-doctoral years in the laboratory of Bert Vogelstein studying molecular cancer genetics. He was appointed to the faculty of Johns Hopkins in 2000 as an instructor and was promoted to full professor in 2008. Dr. Shih's research focus is on the molecular pathogenesis of gynecologic diseases, especially in the fields of gynecologic oncology and gestational trophoblastic diseases. More specifically, his ovarian cancer research team has applied genome-wide analysis, and molecular and cellular biologic techniques along with various animal models to elucidate the molecular etiology and pathogenesis of chemoresistance in ovarian and, most recently, uterine cancer. His work has had a particular emphasis on translational implications, including strategies for ovarian cancer prevention and identification of targetable pathways for new therapeutics. In addition to his gynecologic oncology studies, Dr. Shih is an enthusiastic investigator in human trophoblast pathobiology. He has identified biomarkers to define various types of gestational trophoblastic tumors and tumor-like lesions. Dr. Shih has also led a number of clinicopathological studies in characterizing a variety of gynecologic diseases, and has established the focused Ovarian Cancer Research Tumor Bank at the Johns Hopkins University, which employs an integrative banking strategy and well-annotated clinical information to support the research of many laboratories as well as his own team. As a principal investigator, Dr. Shih has received continuous government funding from NIH/NCI and DoD as a PI or project leader since 2000. In particular, he has been a co-PI of a DoD (multi-institutional) Consortium Development award and of a subsequent Consortium award. Dr. Shih is also an active educator of graduate, undergraduate, and medical students, and has served as a mentor for more than 40 trainees in the past decade. Many of them have received research awards and have become faculty members in academic institutions worldwide. Administratively, Dr. Shih is the co-director of the emerging Female Reproductive Cancer Program at the Johns Hopkins Kimmel Cancer Center, and is the Editor-in-Chief of Current Obstetrics and Gynecology Report (Springer) among several other administrative duties.