Traumatic Brain Injury
   Research Center

Animal models of chronic traumatic encephalopathies

This project focuses on the cellular and molecular mechanisms of injury-induced tauopathies using a repeat-concussion model. This model is based on the impact acceleration (Marmarou) apparatus that was adjusted for use in mice. Genetically modified mice are used to explore the burden of genetic and concussive contributions to traumatic encephalopathies (diathesis-stress design). Diagnostic biomarkers are being developed with Dr. Martin Pomper and his team in Radiology using tau-and-kinase-binding molecules. Experimental therapies are explored with tau compounds.
This project is funded, in part, by the Johns Hopkins Brain Sciences Institute (BSi).

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