Traumatic Brain Injury
   Research Center

Blast injury in human brain and animal models

This project utilizes brain tissues from veterans exposed to combat blast provided through a collaborative agreement with AFIP. In parallel, the project uses a shock tube model of blast injury that was developed in collaboration with Dr Ibolja Cernak when she was at the APL. The neuropathological consequences of blast injury in humans and experimental animals are characterized and compared. Emphasis is on particular types of diffuse axonal injury and chronic neuroinflammation in the form of activated microglial cells. Lessons from animal models are used to clarify mechanisms of blast injury in the human brain.
This project is funded, in part, by the Department of Defense.

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