Traumatic Brain Injury
   Research Center


Research Goals and Current Projects

Our multidisciplinary TBIRC team is focused on discovering the anatomical and molecular basis of the various types of TBI in order to develop diagnostic or prognostic biomarkers and novel therapies. Our approach is to develop and analyze animal models of brain injury in parallel with studies of patients with TBI. This will allow us to understand the fundamental mechanisms of TBI and later life illnesses with which it is associated.

Our goals are: a) to model the problems underlying brain trauma due to blast, concussions and axonal injuries; b) to correlate experimental findings in rodent models with observations from traumatic injury in human brains in order to better understand pathogenic mechanisms; c) to develop brain imaging approaches or chemical reactions in the cerebrospinal fluid or serum (what we call "biomarkers") to diagnose or predict the outcome of TBI; and d) to formulate and test experimental treatment approaches involving small organic compounds, trophic factors, and stem cells. Described below are examples of three separate but linked projects that focus on these issues.

1. Animal models of diffuse axonal injury/multiple-system disconnection.

2. Blast injury in human brain and animal models.

3. Animal models of chronic traumatic encephalopathies.