Johns Hopkins Dome


The new "Blue Book"

Dec 26, 2018
Eye book

The World Health Organization's new "blue book" on the classification of tumors of the eye was just published. Dr. Charles Eberhart is one of the editors of the book and Dr. Fausto Rodriquez also wrote several chapters. The book includes diagnostic criteria, pathological features, and genetic and other associated molecular alterations of tumors of the eye. Congratulations Charles and Fausto!

Nilabh Shastri joins Johns Hopkins

Dec 19, 2018
Nilabh Shastri, M.Sc., Ph.D.

Dr. Nilabh Shastri becomes university's 38th Bloomberg Distinguished Professor after spending more than 30 years at the University of California, Berkeley, where he headed the Division of Immunology and Pathogenesis.

Dr. Shastri joins the Department of Pathology at the School of Medicine, the Department of Biology in the Krieger School of Arts and Sciences, and the Sidney Kimmel Comprehensive Cancer Center.

Welcome Dr. Shastri!

Read more about Dr. Shastri on the Hub.

Congratulations to our new professors!

Dec 17, 2018

A black tie dinner was held at the Peabody Library on December 2nd to honor our new professors. Kathy Burns, M.D., Ph.D., Mario Caturegli, M.D., Bill Clarke, Ph.D., Marc Halushka, M.D., Ph.D., Aaron Tobian, M.D., Ph.D., and Hui Zhang, Ph.D. were recently promoted, and Nilabh Shastri, Ph.D. joined us from Berkeley as a new Bloomberg Distinguished Professor. All of our new professors were recognized by other professors at a beautiful event.

Congratulations Aaron, Bill, Hui, Kathy, Marc, Mario, and Nilabh!

Black tie 2018 1

Congratulations, Alaleh Azhir!

Dec 11, 2018
Alaleh Azhir

Alaleh Azhir was one of 32 American students recently selected from an applicant pool of 880 for a Rhodes Scholarship, which is among the oldest and best-known awards for international study. Established in 1902, the Rhodes Scholarship recognizes students on the basis of outstanding academics and leadership, and winners receive full funding to pursue a degree at Oxford.

Since the beginning of her sophomore year, Azhir has worked in the lab of David Nauen, an Assistant Professor of Pathology at the Johns Hopkins School of Medicine. She helped design and build a tool for visualizing and comparing changes in gene expression that the lab uses to investigate the development of epilepsy. Epilepsy is surprisingly common and can have tremendous adverse impacts. In temporal lobe epilepsy, a genetically typical individual suffers an insult such as trauma or fever. Following a prolonged symptom-free period, sometimes many years later, patients start to experience spontaneous seizures. These are centered in the hippocampal formation. Read more on the Neuropathology Blog >>

Read more about Alaleh Azhir on the Hub.

A Visit to The University of Virginia

Nov 13, 2018
Uva2018 6

On November 13, 2018, Drs. Alisha Ware, Marissa White, Tricia Murdock, Juan Troncoso, and Ralph Hruban, representatives from our Pathology Diversity Committee, traveled to The University of Virginia (UVA). The purpose of the visit was to promote careers in Pathology among groups underrepresented in medicine. The presentation was organized in conjunction with the UVA Chapter of the Student National Medical Association. The room was filled with eager undergraduate and medical students, who had many questions and offered positive feedback. Dr. Alisha Ware began the presentation by introducing the field of Pathology, providing a glimpse of Pathology at Hopkins, and promoting our fully-funded Pathology rotation for groups underrepresented in medicine, including underrepresented minorities and persons from disadvantaged backgrounds. Dr. Marissa White then provided data on the increasing need for diversity in medicine and some of the challenges of being a person underrepresented in medicine. The presentation concluded with Drs. White, Ware, and Murdock sharing personal anecdotes on training as a person underrepresented in medicine, and providing words of encouragement to the students in the group. The team from Hopkins received plenty of positive feedback and interest following the presentation, and looks forward to their next trip to Charlottesville!

Uva2018 5

Congratulations, Norman Barker!

Oct 23, 2018
Norman Barker, M.A., M.S.

Norm Barker, Director of Pathology Photography and Graphics Laboratory, won 7th place in the annual Nikon Small World Photomicrography Competition this year.

The Nikon International Small World Competition first began in 1975 as a means to recognize and applaud the efforts of those involved with photography through the light microscope. Since then, Small World has become a leading showcase for photomicrographers from the widest array of scientific disciplines. Read the article.

Human Tear Drop

Understanding the Early Pathogenesis of Ovarian Cancer

Oct 17, 2018
Wang Kurman Shih

To help facilitate development of ovarian cancer screening approaches, the Ovarian Cancer Research Program (OCRP) sought to promote a major multi-institutional research effort conducted by a multi-institutional team co-directed by Drs. Kurman, Wang, and Shih, that specifically focused on identifying and characterizing early changes in ovarian cancer.

Read the full article.

Congratulations, Kathy Haddaway!

Oct 16, 2018
Kathy Haddaway

Kathy Haddaway, MT(ASCP)SBB, who graduated from the Johns Hopkins Specialist in Blood Banking (SBB) program in September 2018, was the recipient of the AABB Future Leader - Specialty in Blood Banking Scholarship Award. This prestigious award sponsored her travel to the AABB Annual Meeting in Boston in October 2018, where her award was formally presented.

The basis for her award application was a Johns Hopkins-based project that compared the in vitro hemostatic efficacy of fresh whole blood undergoing leukoreduction with a platelet-sparing filter, compared to fresh whole blood undergoing leukoreduction with a non-platelet-sparing filter. Kathy's work showed that the type of filter used for leukoreduction had significant implications for the thromboelastographic profile and on the microscopic aperture closure times of whole blood. Traditional assessments of coagulation such as the prothrombin time, the partial thromboplastin time, factor V activity and factor VIII activity were not significantly affected. Given that whole blood is currently used for neonatal cardiac surgery patients at Hopkins, and the use of whole blood for trauma resuscitations is gaining traction nationally, it is important that transfusion medicine practitioners have a detailed understanding of factors such as the leukoreduction strategy that could affect the performance of whole blood.

Kathy will present her work at the Pathology Symposium session, "Hemostatic Properties of Whole Blood: Implications for the Massive Transfusion Protocol" on Wednesday, October 24th from 2:15-3:15 p.m. Her faculty mentor for the project was Dr. Eric Gehrie (Division of Transfusion Medicine), and she was also generously supported by Drs. Thomas Kickler and Gang Zheng (Hematology and Coagulation). Congratulations, Kathy!

18th Annual Current Topics in Gastrointestinal & Liver Pathology

Oct 15, 2018
18ct gi liver

The 18th annual conference will take place on October 20 & 21, 2018. Participants can claim up to a maximum of 15.0 AMA PRA Category 1 Credits ™ for this activity.
Registration is here.

New Grant Funding Opportunities Available

Jul 19, 2018
Translational Research Cycle

Career Development project grant applications are now available to support investigators involved in projects related to cervical cancer. Priority will be given to investigators focusing on translational research projects, as well as to projects related to the cervical cancer and the human papillomavirus. Investigators performing basic research that has obvious, near-term potential application will also be considered. Funds for the career development project program are provided by our NCI Cervical Cancer SPORE grant.
Download the submission guidelines
Deadline for submission August 3, 2018

Pilot Project grant applications are now available to support new projects in advanced cervical cancer related research. Priority will be given to translational research projects as well as to projects related to cervical cancer and the human papillomavirus. Basic research that has obvious, near-term potential application will also be considered. Funds for the pilot project program are provided by our NCI Cervical Cancer SPORE grant.
Download the submission guidelines
Deadline for submission August 3, 2018.

20th National Native American Youth Initiative

Jul 3, 2018
Nnayi 2

Thanks to Dr. Tricia Murdock for organizing inspiring sessions on the Broadway campus and in Washington D.C., as part of the National Native American Youth Initiative. On Thursday, June 28, the students toured the Hospital and the Department of Art as Applied to Medicine, and the following Saturday, Drs. Murdock, Voltaggio and Hruban spent an inspiring morning teaching the young Native American students about pathology. The sessions were organized by Dr. Murdock and the Association of American Indian Physicians. The students asked thoughtful questions and their knowledge was impressive ÔÇô future leaders in medicine!

Nnayi 6

Mr. Barker and Drs. Grabowski, Koliatsos, Wang, and Wood receive 2018 Discovery Awards

Jun 28, 2018

Five Pathology faculty members, Mr. Norman Barker, and Drs. Kate Grabowski, Vassilis Koliatsos, Tian-Li Wang, and Laura Wood, recently received the Johns Hopkins Discovery Award from the Office of the Provost. These awards support creative projects, innovative and collaborative research. Altogether, the winning project teams-chosen from 190 proposals-include 108 individuals representing 11 Johns Hopkins entities. The expectation is that these awards will spark new, synergistic interactions between investigators across the institution and lead to work of the highest quality and impact.

Congratulations, Norm, Kate, Vassilis, Tian-Li, and Laura!

Barker Grabowski Koliatsos Wang Wood lge

Drs. Amukele and Sfanos receive 2018 Catalyst Award

Jun 22, 2018
Amukele Sfanos

Two Pathology faculty members, Drs. Tim Amukele and Karen Sfanos, recently received the Johns Hopkins Catalyst Award from the Office of the Provost. These awards support the research and creative endeavors of early career faculty across Johns Hopkins. The current cohort, named in June 2018, includes 32 early-career faculty members from across the University, including the Schools of Arts and Sciences, Carey Business School, Medicine, Engineering, Peabody Institute, Public Health, and Advanced International Studies. The group includes anthropologists, astronomers, economists, and engineers (among many others!), and Drs. Amukele and Sfanos were among only 16 awardees from the School of Medicine. The goal of the Catalyst Award is to launch these faculty members on a path to a sustainable and rewarding academic career. These awards include both funding and mentoring opportunities and will greatly support the expansion of their independent research groups. Dr. Amukele's project is "Design, construction, and validation testing of a biohazard transport box for drones," and Dr. Sfanos's project is "The effect of the gastrointestinal microbiota on the development of castration resistance in metastatic prostate cancer."

Congratulations, Tim and Karen!

Using Rapid Autopsies for Research

Jun 18, 2018
J Hooper

Dr. Jody Hooper is featured in an article in the Baltimore Sun on the value of rapid autopsies. In the article, it was noted that Dr. Hooper has performed about 60 rapid autopsies since 2014. The rise in popularity of launching the same program in other medical institutions comes from the significant clinical contribution the program has in continuing the battle for cancer and other diseases.

Read the full article.

Congratulations, Dr. Simner!

Jun 13, 2018
P Simner

At the recent American Society for Microbiology Microbe 2018 Meeting, Dr. Patricia Simner was the recipient of the Diagnostics Young Investigator Award. On June 8th, Dr. Simner presented her award lecture entitled "Metagenomic Approaches to Resistance Detection." As described by one attendee, "Her talk was truly amazing - one of the best of the entire meeting." Well done, Trish!

4th Annual Fred and Janet Sanfilippo Lecture

Jun 8, 2018

Mark L. Tykocinski, M.D., the Provost of Thomas Jefferson University and Dean of the Sidney Kimmel Medical College at Jefferson, gave the fourth annual Fred and Janet Sanfilippo Lecture on Monday, June 11, 2018. Dr. Tykocinski's talk, "The Future of Medical Education: Osler-Flexner Redux," outlined key landmark events in the evolution of medical education in the U.S., and painted an inspiring vision of the future of medical education. Dr. Tykocinski described the 21st century medical student as one who "thrives in a world of perpetual change, collaborates across knowledge domains, thinks critically, leverages data science, and evolves into a humanistic, impactful citizen of society." Following the lecture, our resident Daniel Miller, M.D., Ph.D., was recognized as the recipient of this year's Fred and Janet Sanfilippo Research Award.

Fred and Janet Sanfilippo Lecture

Congratulations, Audrey Knight!

Jun 4, 2018
A Knight

We are proud to announce that Audrey Knight, a 3rd year graduate student in the Pathobiology Graduate Program, has been awarded an R25 pilot grant from the NIMH titled: "Dysregulation of central nervous system glial immune responses in a cART-suppressed SIV/macaque model of chronic HIV CNS disease."

Audrey Knight is from St. Louis, Missouri and received her Bachelors of Science degree in biology from Illinois College in 2014. While at Illinois College, she conducted several independent research projects focusing on RNA interference, synthetic chemistry, virology, and orchid conservation. Audrey joined the lab of Joseph Mankowski, DVM, PhD, DACVP, in 2016 where she studies the role of microglia in HIV associated neurocognitive disorders (HAND) using an SIV/macaque model.

Congratulations, Karim Nabi!

May 29, 2018
K Nabi

Congratulations to Karim Nabi, a senior Johns Hopkins student working under the mentorship of Dr. Anne Le, for his election to The American Association for Cancer Research (AACR) Scholars! AACR, the oldest and largest organization in the world dedicated to cancer research, has provided two-year awards to 10 young scientists as they begin their careers.

Read the full article

Sue Carreira Memorial Service

May 23, 2018
Sue Carreira

It is with great sadness that we inform you of the passing of Sue Carreira after a brief illness. Sue was a valued member of our Pathology administrative team and has provided outstanding support since 1997. She will be greatly missed.

This is a difficult time not only for Sue's family but also for all of us who have worked with Sue. Please keep Sue and her family and friends in your thoughts at this time.

The family will receive friends at the Leonard J. Ruck, Inc. Funeral Home, 5305 Harford Road (at Echodale), Saturday, June 9th from 6-8 PM with a memorial service following at 8 PM.

Graduation Dinner 2018

May 16, 2018
FD60407 F

The Department held its annual Graduation Dinner (also known as our "prom") at the Royal Sonesta on Friday, May 11th. A beautiful cocktail reception on the garden roof of the hotel was followed by dinner and speeches from our chief residents and chief graduate students. In celebration of our diversity and the 125th anniversary of the founding of the School of Medicine, guests also had the opportunity to sign a scroll commemorating Johns Hopkins' 1873 letter to the trustees of the university ( ). Special thanks to Nancy Nath and her team for organizing a special evening!

125th Anniversary of the Johns Hopkins School of Medicine - Mr. Johns Hopkins' Letter

May 11, 2018

Dr. Ralph Hruban invites you to help us celebrate the 125th anniversary of educating and training thousands of people who have gone on to set the standard for education, patient care and research in the United States and beyond.

In 1873, Mr. Hopkins wrote a letter to the trustees of the newly formed hospital. In this letter, he stipulated that a school of medicine be established alongside the hospital as part of his bequest:


In all your arrangements in relation to this hospital, you will bear constantly in mind that it is my wish and purpose that the institution shall ultimately form a part of the Medical School of that university for which I have made ample provision by my will.

Mr. Hopkins

Through persistent scientific inquiry, the pursuit of scientific and medical innovations, and the creation of new model of medical education, we continue to advance our mission as directed by Mr. Johns Hopkins. It is an important moment to celebrate all we've accomplished as an institution and as a world leader in medicine and science as we strive to gain new inspiration for the future. In doing so, we revisit the founding of our institution and the principles that underlie it. Central to Johns Hopkins Medicine now and Mr. Johns Hopkins then, is the importance of our core values:

Excellence & Discovery, Leadership & Integrity, Diversity & Inclusion, and Respect & Collegiality.

Beginning this week, you will have an opportunity to sign a commemorative scroll representing Mr. Johns Hopkins' letter to the trustees of the hospital. The signing of the scroll is meant to be a gesture to symbolize one's commitment to the Johns Hopkins mission and our core values.

You are encouraged to a view the video below created by The Johns Hopkins Medicine Office of Diversity and Inclusion which highlights the importance and relevance of this letter for our institution today and for the future.

Thanks to his vision, we continue to deliver the promise of medicine.
We are better together.
We are Hopkins.

Congratulations to the Class of 2018!

May 10, 2018
Onthe Dome2018

As has become a wonderful department tradition, our graduating residents visited the historic Billings Building and went to the top of the "dome". The views of Hopkins and of the city were breathtaking, and this tradition welcomes our graduating residents to our family and to our history. Best wishes to the class of 2018!

Congratulations, Dr. Jody Hooper!

Apr 23, 2018
Jody E. Hooper, M.D.

Dr. Jody Hooper is featured in an article in Time Magazine on the value of rapid autopsies. In the story Dr. Hooper notes the power of sampling diseases such as cancer "over the entire body at the same time." To learn more about Dr. Hooper's Legacy Gift Rapid Autopsy Program visit:

Congratulations, Dr. Angelo Demarzo!

Apr 18, 2018
Angelo De Marzo, M.D., Ph.D.

Angelo Demarzo, M.D., Ph.D. was inducted into the Association of American Physicians. The Association of American Physicians is an honorific, elected society of America's leading physician-scientists who "exemplify the pinnacle of pioneering and enduring, impactful contributions to improve health." Wonderfully well-deserved Angelo!

AAP Dinner 2018 lge

National Medical Laboratory Professionals Week, April 22-28

Apr 17, 2018

The Department of Pathology celebrates National Medical Laboratory Professionals Week, April 22-28, 2018. The Department thanks all of its employees for their dedicated service and commitment to patient care.

Dr. Humphrey Memorial Service

Apr 11, 2018
Dr Richard Humphrey sm

We are very saddened to announce that Richard L. Humphrey, M.D., a distinguished and devoted faculty in the Department of Pathology passed away on March 26, 2018. Dr. Humphrey served as associate professor of pathology, oncology, and medicine of the Johns Hopkins University School of Medicine, had a joint appointment in the Johns Hopkins Bloomberg School of Public Health, and served as the director of the Immunology Laboratory for many years.

Dr. Humphrey's long and distinguished career at Johns Hopkins Medicine began in 1960 when he came here as an intern and resident in the Department of Medicine. He subsequently was a postdoctoral fellow in the Departments of Biology and Biophysics, and went on to serve as a physician in medicine and oncology, and at the Baltimore City Hospitals (now Johns Hopkins Bayview Medical Center). He was a member of the medical staff since 1967.

In 1977, Dr. Richard Humphrey created the early beginnings of the Diagnostic Immunology Laboratory in the Department of Pathology. Here he brought his unique expertise in laboratory tests for evaluating patients with monoclonal gammopathies. Dr. Humphrey, a medical oncologist, was nationally known in the field of plasma cell dyscrasias and was the first to develop electrophoresis and immunoelectrophoresis assays at JHU. In addition to his invaluable laboratory contributions, Dr. Humphrey also distinguished himself as a gifted teacher. He brought to all of his teaching activities a depth of knowledge as well as exuberance for his work that served to motivate and challenge everyone he taught. In 1999, he transitioned into a teaching position but continued to work and provide consultation in the newly renamed Immunology Laboratory until 2017. Dick relished the idea of remaining, on a part time basis, in the Immunology Laboratory, providing his vast expertise in monoclonal gammopathies and resident training. Dick was highly valued and much loved by his Hopkins colleagues - especially in the Immunology Laboratory. He was enormously generous with his time, knowledge and support. In the laboratory he served as the initial teacher to all faculty who signed out monoclonal protein reports.

During his long and distinguished career, which spanned over 50 years, Dick will always be remembered as an exceptional role model, dedicated teacher, and clinical laboratory scientist in pursuit of excellence. In recognition of his outstanding commitment to teaching, Dr. Humphrey was thrice awarded the Johns Hopkins Hospital Clinical Pathology Faculty Teaching Award. Dick's research interests include plasma cell dyscrasias, immunoglobulin structure and function, bone marrow transplantation, amyloidosis, hyperviscoscity syndromes and cryoglulinemia. He authored over 80 papers and 35 chapters in the fields of oncology and immunology.

Our deepest condolences to Dr. Humphrey's wife Lauralee and his family.

There will be a private burial and a memorial service will be held later this spring at the First Unitarian Church of Baltimore. In lieu of flowers, the family will announce Dr. Humphey's favorite charities.

USCAP 2018

Mar 26, 2018

We had another wonderful reception at the 2018 meetings of the United States and Canadian Academy of Pathology in Vancouver, Canada. The alumni of the Department not only shared many memories, but also celebrated the 125th anniversary of the founding of the Johns Hopkins University School of Medicine.

USCAP 2018 Presentations


Congratulations, Dr. Marc Halushka!

Mar 14, 2018
Mentor Award Halushka

Dr. Marc Halushka was selected as an outstanding faculty mentor with receipt of the 2018 Award for Excellence in Mentoring sponsored by the Scholarly Concentrations in the School of Medicine. This award recognizes the faculty mentor who best embodies the goals of the Scholarly Concentrations Program in fostering the spirit of independent scholarship among Johns Hopkins medical students. As one student expressed,

"Working with Dr. Halushka for the past year has been the biggest and best decision I have made since choosing to come to Johns Hopkins. He is a supportive mentor and an excellent researcher with the kindest heart that one can imagine."

Dr. Halushka was presented with this award at the 2018 Medical Student Research Symposium in February.

New Prostate Pathology app is in the iTunes store!

Mar 12, 2018
Prostate Pathology App

We are pleased to announce the release of our new educational iPAD application on prostate pathology!

The Johns Hopkins Atlas of Prostate Pathology is now available in the iTunes Store. This app is designed to teach residents, fellows, and practicing pathologists the intricacies of prostate pathology, covering a wide range of entities from benign to malignant, and common to rare. It contains a multitude of microscope images that highlight and discuss different features essential to making diagnoses in prostate pathology.

The app is composed of five different modules: features supporting a diagnosis of carcinoma, features of atypical glands suspicious for carcinoma, a teaching algorithm for cancer grading, a discussion of the new cancer grade grouping, and instructions for measuring involvement of a needle core biopsy by cancer. A searchable image atlas and image-based quiz are also available for further study. Viewing multiple examples of the same entity/feature will help hone and strengthen your skills of prostate pathology!

Black History in Baltimore

Mar 7, 2018

In honor of National Black History Month, Ava Roberts, MLS(ASCP)CM, clinical laboratory scientist in the Microbiology Laboratory, gave a special presentation entitled "Black History in Baltimore: A Brief Overview of Baltimore's Black History Through Monuments and Landmarks" to the department on February 7, 2018. Watch the presentation below.

Congratulations, Dr. Trish Simner!

Feb 23, 2018
Distinguished Alumni Award Dr Trish Simner

Dr. Trish Simner received a 2018 Distinguished Alumni Award from the University of Manitoba. In giving Dr. Simner this award, the University noted that, "Dr. Simner's work reflects the future of microbiologists. Already given several prestigious awards, she is an excellent role model for potential microbiologists, especially young women. Her work on the mechanisms of anti-microbial resistance is timely and necessary. Collaborations include those with the Antimicrobial Resistance Surveillance Taskforce for the CDC." Congratulations!

2017 Publications

Feb 19, 2018

Our faculty published more than 200 original peer-reviewed first/last author publications in 2017! From studies of microRNA expression to large epidemiological studies, the impact of this science is breath taking! To learn more click here.

#1 in NIH Funding in 2017

Feb 19, 2018

The Blue Ridge Institute released its 2017 rankings of NIH funding to US medical schools, and the Department of Pathology here at Hopkins once again is recognized as the #1 funded pathology department! This makes the department #1 in NIH funding for 10 of the last 11 years. In addition, Sharon Nachman, Susan Eshleman and TC Wu were among the top 25 funded pathologists in the US.
From fighting HIV in Africa, to cancer in the inner city, our faculty are dedicated to impactful science.


Click here to view the full list in Pathology

Rank Name Pathology
1 Johns Hopkins University $53,745,19
2 University of Pennsylvania $33,595,740
3 Washington University $33,172,751
4 University of Washington $28,574,568
5 Emory University $28,197,113
6 Columbia University Health Sciences $27,678,680
7 Stanford University $26,966,391
8 University of Michigan $25,215,399
9 New York University School of Medicine $20,242,440
10 Case Western Reserve University $15,311,283

Congratulations, Dr. Kathy Burns!

Feb 14, 2018
Dr Kathy Burns

Congratulations to Kathy Burns for her election to the American Society for Clinical Investigation (ASCI)! ASCI is one of the nation's oldest and most respected medical honor societies. It is made up of more than 3,000 physician-scientists from all medical specialties who are elected for outstanding scholarly achievements in biomedical research. Kathy will give the new member presentation at the ASCI Annual Meeting in Chicago this spring. She joins Charles Eberhart (elected 2010) and T.C. Wu (elected 2002) from our department.

Diversity Cover Story

Feb 7, 2018
Tricia Murdock, M.D.

Our very own Tricia Murdoch, M.D. was recently featured in the Johns Hopkins Medicine publication Diversity and Inclusion 2017. The piece tells Tricia's remarkable journey - growing up on the Tuscarora Nation (a Native American reservation in New York), to the University of Buffalo, the NIH, the University of Washington, and eventually to fellowship training at Johns Hopkins. Tricia is now on our faculty in GYN Pathology.

Click here to learn more about Tricia's remarkable journey.

Insight from Dr. Daniela Čiháková

Jan 26, 2018
Daniela Cihakova, M.D., Ph.D.

Dr. Čiháková published Insight article in Journal of Experimental Medicine discussing diverse population of cardiac-resident macrophages and their critical role in the pathogenesis of heart failure. A new understanding of communication between macrophages and cardiac fibroblasts could lead to novel therapeutic strategies for heart failure with preserved ejection function.

Read the full article.

Congratulations, Carrie!

Jan 22, 2018
Carrie Holdren Serrell

Congratulations to Carrie Holdren-Serrell of the Microbiology Lab! Carrie was chosen as a recipient of the 2017 Martin Luther King Community Service Award. This award is presented to employees of Johns Hopkins Medicine in honor and recognition of their significant community service. Read more about Carrie

Advance in ALS Research

Jan 18, 2018
Shuying Sun, Ph.D.

Pathology department and Brain Science Institute researcher Shuying Sun and her group have uncovered a mechanism by which genetic alterations common in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and some dementias may promote loss of neurons. They focus on how aberrant proteins are produced in disease, and their findings suggest a possible new point of therapeutic intervention. Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both ALS and frontotemporal dementia (FTD). Unconventional translation of the repeat-containing RNA produces multiple toxic poly-dipeptides, which contribute to neurodegeneration. The new study demonstrates that the repeat translation is upregulated by various stress stimuli through phosphorylation of the &alpha subunit of eukaryotic initiation factor-2 (eIF2α), the core event of an integrated stress response. Compounds inhibiting phospho-eIF2α-signaling pathways were shown to suppress translation of the repeats. Since the poly-dipeptides can themselves induce stress, this could trigger a feedforward loop with initial repeat-mediated toxicity enhancing the repeat translation and subsequent production of additional poly-dipeptides, thereby driving relentless disease progression. A method perturbing this loop might reduce or delay neurodegeneration and hold therapeutic promise in C9ORF72-ALS/FTD. The study was recently published in Nature Communications

Dr. King Memorial Service

Jan 11, 2018
Dr Karen King

We lost a very dear friend and colleague, Dr. Karen E. King, on January 5, 2018 at the age of 56. Karen graduated from Wellesley College (1982) and the Johns Hopkins School of Medicine (1986). She went on to complete her residency in Pathology (1991) and fellowship in Transfusion Medicine (1993-1996), after which she was recruited to the Hopkins faculty in 1996. She subsequently rose to the ranks of Professor in 2016, becoming the 227th woman Professor at Hopkins. Karen brought immense enthusiasm, hope, and strength to all that she did, and it was through these unique qualities that she cared for patients, taught students and colleagues, pioneered new horizons in transfusion medicine, and battled cancer until the very end. Karen was known for her intellect, energy, and brilliant smile, which she shared freely with her family, friends, colleagues, and the many students, residents and fellows whom she taught. She considered her students and mentees to be family, providing a role model to all who had the privilege of working and learning from her. A beloved teacher, Karen was awarded the Resident's Teaching Award. First and foremost, she led by example and inspired others by her indefatigable efforts on behalf of her patients and trainees. Karen encouraged those around her to dream big and realize all that their careers could evolve into, shying away from pre-established conventions. Through her work in pathology and transfusion medicine, she was affectionately known as the institution's "interventional pathologist". Not content to fill an assigned role, she created something unique and unmatched. Perhaps more than most anything else, Karen was an inspiration to all of those who have worked with her over the years.

She was also a dedicated physician-scientist whose contributions advanced the field and therapy for countless patients. Karen built the Hemapheresis and Transfusion Support (HATS) Division at Hopkins from the ground up; this program provides specialized transfusion care to diverse patients with complicated medical disorders. She served not only as the Medical Director of HATS, Director of the Transfusion Medicine Fellowship, but also the Associate Director of the Pathology Residency Program and Associate Medical Director of Transfusion Medicine. She was recognized worldwide as an expert in apheresis and the management of complex immunologic and blood disorders, including sickle cell anemia, cancer, neurologic disorders, and organ transplantation. Thanks to Karen, today over 2500 therapeutic apheresis cases are performed at Johns Hopkins every year. To advance our understanding and care of complicated patients requiring blood transfusion, she was a prolific scientist, imparting her knowledge and expertise through the medical literature and over 60 invited lectures throughout the world. Karen was honored with the American Association of Blood Banks (AABB) Presidential Award this past October in recognition of her "tremendous service to AABB through education, mentorship and numerous appointments to AABB committees, including associate editor of Transfusion and for her leadership in apheresis and organ transplant immunohematology as well as her devotion to training junior members in the field of transfusion medicine."

In addition to her medical career, Karen was a talented pianist who trained at the Peabody Conservatory and in France at the École des Beaux-Arts at Fountainebleu. She also established an exchange program whereby students from Japan came to study at Hopkins, and Hopkins students had the opportunity to study in Japan.

Karen is survived by her husband, Porter Siems, their three children, Lilly, Elizabeth, and Matthew, her brother Ted Jr, and her mother, Mrs. Lilly King. Karen's father, Dr. Theodore King, was a long-term member of the Hopkins family. He served as the Vice President for Medical Affairs, Director of the Department of Gynecology and Obstetrics, and he helped to establish the Johns Hopkins Program for International Education in Gynecology and Obstetrics (JHPIEGO).

Simply put, Karen was a much-loved member of the Department of Pathology and Hopkin's family. Her impact was beyond measure, and she will live on in the hearts and memories of those she touched.

Karen's family will receive well-wishers at Ruck's Funeral Home in Towson (1050 York Road, Beltway exit 26) on Friday, January 12th, from 3 pm to 5 pm and from 7 pm to 9 pm, and a memorial service will be held at the Church of the Redeemer (5603 N. Charles St., Baltimore, MD 21210) on Saturday, January 13th at 11 am. The family requests that in lieu of flowers, memorial donations may be made to Hopewell Cancer Support, 10628 Falls Rd., Lutherville, MD 21093 or Wellesley College.

Congratulations, Dr. Juan Millan!

Jan 8, 2018
Juan Millan sm

Congratulations Dr. Juan Millan (fellow from 1972 to 1975 and in the Faculty from 1975 to 1989). Juan was awarded the College of American Pathologists 2017 Lifetime Achievement Award. This award recognizes Juan's service to the CAP's Laboratory Accreditation Program. Juan served as deputy commissioner to the systems since 2008, on the Complaints and Investigation Committee (2007-2015) and he has been a delegate to the CAP since 2003. Juan is currently Director of Laboratories at Legacy Health in Portland Oregon. Congratulations Juan!

Red Cross Blood Drives

Jan 5, 2018
Red Cross Blood Drive 2018

There are many Red Cross Blood Drives scheduled for the Hopkins community-across all Hospitals and all locations-throughout 2018. Please click the image above to see the entire list. Please consider a donation to save lives.