Division of Cardiovascular Pathology


Dr. Charles Steenbergen

Charles J. Steenbergen, M.D., Ph.D.

My research is on mechanisms of ischemic heart disease, and in particular, endogenous mechanisms that can be activated to protect the heart during episodes of ischemia and reperfusion. I am interested in identifying signal transduction pathways that are involved in cardioprotection, and understanding how these signaling pathways confer their protective effect. Recently, we have become interested in how microRNA can regulate mitochondrial protein synthesis and alter mitochondrial function, and we have worked on novel methods for measuring S-nitrosylation, a form of post-translational protein modification that is important in heart disease, and is usually cardioprotective. We hope that better understanding of these mechanisms will lead to the development of better therapies for patients with coronary artery disease, heart failure, and patients undergoing heart surgery.
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Contact Dr. Steenbergen:
phone: (410) 502-5982

Dr. Marc Halushka

Marc K. Halushka, M.D., Ph.D.

MicroRNAs are key post-translational regulators of genes. We are interested in the distribution of microRNAs in human tissues and cells. We are also interested in determining how these microRNAs are altered in human diseases. My laboratory is also involved in a number of collaborative projects relating to cardiovascular diseases such as sudden cardiac death, cardiac citrullination and neonatal lupus.
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Contact Dr. Halushka:
phone: (410) 614-8138