Division of Gastrointestinal and Liver Pathology

Primary Publications

Recent (July 2016 - June 2017) +
  1. Ayars M, Eshleman J, Goggins M. Susceptibility of ATM-deficient pancreatic cancer cells to radiation. Cell Cycle 2017 May 19;16(10):991-8.
  2. Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, Liu Y, Wu N, Joseph NE, Wang TL, Zhang N, Pan D, Alpini G, Robinson DN, Anders RA. Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization. Am J Physiol Gastrointest Liver Physiol 2016 Sep 1;311(3):G396-411.
  3. Dal Molin M, Brant A, Blackford AL, Griffin JF, Shindo K, Barkley T, Rezaee N, Hruban RH, Wolfgang CL, Goggins M. Obstructive Sleep Apnea and Pathological Characteristics of Resected Pancreatic Ductal Adenocarcinoma. PLoS One. 2016 Oct 12;11(10):e0164195.
  4. Debeljak M, Mocci E, Morrison MC, Pallavajjalla A, Beierl K, Amiel M, Noë M, Wood LD, Lin MT, Gocke CD, Klein AP, Fuchs EJ, Jones RJ, Eshleman JR. Haplotype counting for sensitive chimerism testing: Potential for early leukemia relapse detection. J Mol Diagn 2017 May;19(3):427-36.
  5. Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, Hartung T, Rojas CJ, Rais R, Tsukamoto T, Semenza GL, Hanes J, Slusher BS, Le A. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci USA 2016 Sep 6;113(36):E5328-36.
  6. Eze OP, Montgomery EA. Inflammatory Cell-Rich soft tissue tumors. AJSP:RR 2017 March-April;22(2):75-84.
  7. Goyal G, Montgomery E. Selected benign pediatric fibroblastic and myofibroblastic lesions. AJSP:RR 2017 March-April;22(2):102-7.
  8. Hackeng WM, Brosens LA, Poruk KE, Noë M, Hosoda W, Poling JS, Rizzo A, Campbell-Thompson M, Atkinson MA, Konukiewitz B, Klöppel G, Heaphy CM, Meeker AK, Wood LD. Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis. Hum Pathol. 2016 Oct;56:93-100.
  9. Hackeng WM, Montgomery EA, Giardiello FM, Singhi AD, Debeljak M, Eshleman JR, Vieth M, Offerhaus GJ, Wood LD, Brosens LA. Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis. Histopathology 2017 Mar;70(4):549-57.
  10. Hata T, Dal Molin M, Suenaga M, Yu J, Pittman M, Weiss MJ, Canto M, Wolfgang CL, Lennon AM, Hruban AM, Goggins MG. Cyst fluid telomerase activity predicts the histologic grade of cystic neoplasms of the pancreas. Clin Cancer Res. 2016 Oct 15;22(20):5141-51.
  11. Hosoda W, Chianchiano P, Griffin JF, Pittman ME, Brosens LA, Noe M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R, Ning Y, Albores-Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S, Shimizu M, Uehara T, Samra JS, Gill AJ, Wolfgang CL, Goggins MG, Hruban RH, Wood LD. Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4. J Pathol. 2017 May;242(1):16-23.
  12. Hosoda W, Wood LD. Molecular genetics of pancreatic neoplasms. Surg Path Clin 2016 Dec;9(4):685-703.
  13. Kherad-Pezhouh M, Montgomery E. Nerve Sheath Tumors. AJSP:RR 2017 March-April;22(2):85-93.
  14. Lokhandwala PM, Riel SL, Haley L, Lu C, Chen Y, Silberstein J, Zhu Y, Zheng G, Lin MT, Gocke CD, Partin AW, Antonarakis ES, Luo J, Eshleman JR. Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting. J Mol Diagn. 2017 Jan;19(1):115-25.
  15. Pezhouh MK, Rezaei MK, Shabihkhani M, Ghosh A, Belchis D, Montgomery EA, Voltaggio L. Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract: a case series. Hum Pathol. 2017 Apr;62:199-205.
  16. Pittman ME, Brosens LAA, Wood LD. Genetic Syndromes with Pancreatic Manifestations. Surg Path Clins 2016 Dec;9(4):705-15.
  17. Pittman ME, Khararjian A, Wood LD, Montgomery EA, Voltaggio L. Prospective identification of Helicobacter pylori in routine gastric biopsies without reflex ancillary stains is cost-efficient for our health care system. Hum Pathol 2016 Dec;58:90-6.
  18. Poruk KE, Blackford AL, Weiss MJ, Cameron JL, He J, Goggins MG, Rasheed Z, Wolfgang CL, Wood LD. Circulating Tumor Cells Expressing Markers of Tumor Initiating Cells Predict Poor Survival and Cancer Recurrence in Patients with Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2017 Jun;23(11):2681-90.
  19. Roberts NJ, Norris AL, Wolfgang CL, Wood LD, Zandi PP, Goggins M, Karchin R, Eshleman JR, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH, Klein AP. Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. Cancer Discov 2016 Feb;6(2):166-75.
  20. Tarabishy Y, Montgomery EA. Vascular lesions of intermediate malignancy and angiosarcoma. AJSP:RR 2017 March-April;22(2):108-15.
  21. Tarabishy Y, Pittman M. Soft Tissue Tumors With Myxoid Stroma: A Review of Distinguishing Clinical and Pathologic Features. AJSP:RR 2017 March-April;22(2):94-101.
  22. Vieth M, Montgomery E. Medication-associated gastrointestinal tract injury. Virchows Arch 2017 Mar;470(3):245-66.
  23. Voltaggio L, Cimino-Mathews A, Bishop JA, Argani P, Cuda JD, Epstein JI, Hruban RH, Netto GJ, Stoler MH, Taube JM, Vang R, Westra WH, Montgomery EA. Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system. CA Cancer J Clin. 2016 Sep;66(5):408-36.
  24. Wood LD, Noë M, Hackeng W, Brosens LA, Bhaijee F, Debeljak M, Yu J, Suenaga M, Singhi AD, Zaheer A, Boyce A, Robinson C, Eshleman JR, Goggins MG, Hruban RH, Collins MT, Lennon AM, Montgomery EA. Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas. Virchows Arch 2017 Apr;470(4):391-400.

2016 (January - June) +
  1. Illei PB, Alewine C, Zahurak M, Cowan ML, Montgomery E, Hassan R, Xiang L, Pastan I, Kelly RJ. Mesothelin expression in advanced gastroesophageal cancer represents a novel target for immunotherapy. Appl Immunohistochem Mol Morphol 2016 Apr;24(4):246-52.
  2. Molin MD, Kim H, Blackford A, Sharma R, Goggins M. Glucagon-like peptide-1 receptor expression in normal and neoplastic human pancreatic tissues. Pancreas 2016 Apr;45(4):613-9.
  3. Adsay V, Jang JY, Klimstra DS, Hruban RH; Members of the Verona Consensus Meeting, 2013. Pathologic evaluation and reporting of intraductal papillary mucinous neoplasms of the pancreas and other tumoral intraepithelial neoplasms of pancreatobiliary tract: recommendations of Verona Consensus Meeting. Ann Surg. 2016 Jan;263(1):162-77.
  4. Dudley JC, Lin MT, Le DT, Eshleman JR. Microsatellite instability as a biomarker for PD-1 blockade. Clin Cancer Res 2016 Feb;22:813-20.
  5. Gupta RK, Xie BH, Patton KT, Lisovsky M, Biurks E, Behrman SW, Klimstra D, Deshpande V. Follicular pancreatitis: a distinct form of chronic pancreatitis-an additional mimic of pancreatic neoplasms. Hum Pathol. 2016 Feb;48:154-62.
  6. Rezaee N, Barbon C, Zaki A, He J, Salman B, Hruban RH, Cameron JL, Herman JM, Ahuja N, Lennon AM, Weiss MJ, Wood LD*, Wolfgang CL*. Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma. HPB (Oxford) 2016 Mar; 18(3):236-46.

2015 Annual Report +
  1. Arnold CA, Roth R, Arsenescu R, Harzman A, Lam-Himlin DM, Limketkai BN, Montgomery EA, Voltaggio L. Sexually transmitted infectious colitis vs inflammatory bowel disease: distinguishing features from a case-controlled study. Am J Clin Pathol 2015 Nov;144(5):771-81.
  2. Ayars M, Goggins M. Pancreatic cancer: Classifying pancreatic cancer using gene expression profiling. Nat Rev Gastroenterol Hepatol 2015 Nov;12(11):613-4.
  3. Banet N, Ning Y, Montgomery EA. Inflammatory myofibroblastic tumor of the placenta: a report of a novel lesion in 2 patients. Int J Gynecol Pathol 2015 Sep;34(5):419-23.
  4. Basturk O*, Hong SM*, Wood LD*, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LAA, Fukushima N, Goggins M, Hruban RH, Kato Y, Kern SE, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJA, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T. A revised classification system and recommendations from the Baltimore consensus meeting for neoplastic precursor lesions in the pancreas. Am J Surg Pathol 2015 Dec; 39(12):1730-41. (*equal authorship).
  5. Bhaijee F, Arnold C, Lam-Himlin D, Montgomery EA, Voltaggio L. Infectious mimics of inflammatory bowel disease. Diagnstc Histopathol 2015 July;21(7):267-75.
  6. Bhaijee F, Deyrup A, Montgomery E. Immunosupression-associated soft tissue tumors. Histopathology 2015 Nov;21(11): 432-7.
  7. Brosens LA, Hackeng WM, Offerhaus GJ, Hruban RH, Wood LD. Pancreatic adenocarcinoma pathology: changing "landscape". J Gastrointest Oncol 2015 Aug;6(4):358-74.
  8. Canto IM, Hruban RH. Diagnosis: A step closer to screening for curable pancreatic cancer? Nat Rev Gastroenterol Hepatol. 2015 Aug;12(8):431-2.
  9. Canto IM, Hruban RH. Managing pancreatic cysts: less is more? Gastroenterology. 2015 Apr;148(4):688-91.
  10. Celeiro-Muñoz C, Huebner TA, Robertson SA, Pittman ME, Singhi AD, Arnold CA, Bhaijee F, Voltaggio L, Montgomery EA. Tactile corpuscle-like bodies in gastrointestinal-type mucosa: a case series. Am J Surg Pathol 2015 Dec;39(12):1668-72.
  11. Dal Molin M, Zhang M, de Wilde RF, Ottenhof NA, Rezaee N, Wolfgang CL, Blackford A, Vogelstein B, Kinzler KW, Papadopoulos N, Hruban RH, Maitra A, Wood LD. Very long-term survival following resection for pancreatic cancer is not explained by commonly mutated genes: results of whole-exome sequencing analysis. Clin Cancer Res 2015 Apr 15;21(8):1944-50.
  12. Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M. KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound. Clin Gastroenterol Hepatol 2015 May;13(5):963-9.
  13. Khurram M, Montgomery E. Lanthanum carbonate-associated injury to the small intestine. Daignostic Histopathology 2015 Nov;21(11):452-4.
  14. Khurram M, Xie Y, Montgomery E. Recently described and recently re-evaluated soft tissue tumours. Diagnostic Histopathology 2015 Nov;21(11):445-51
  15. Lennon AM, Wolfgang CL, Canto MI, Klein AP, Herman JM, Goggins M, Fishman EK, Kamel I, Weiss MJ, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH. The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? Cancer Res. 2014 Jul 1;74(13):3381-9.
  16. Lin EI, Tseng LH, Gocke CD, Reil S, Le DT, Azad NS, Eshleman JR. Mutational profiling of colorectal cancers with microsatellite instability. Oncotarget 2015 Dec;6(39):42334-44.
  17. Matthaei H, Semaan A, Hruban RH. The genetic classification of pancreatic neoplasia. J Gastroenterol. 2015 May;50(5):520-32.
  18. Norris AL, Kamiyama H, Makohon-Moore A, Pallavajjala A, Morsberger LA, Lee K, Batista D, Iacobuzio-Donahue CA, Lin MT, Klein AP, Hruban RH, Wheelan SJ, Eshleman JR. Transflip mutations produce deletions in pancreatic cancer. Genes Chromosomes Cancer 2015 Aug;54(8):472-81.
  19. Norris AL, Roberts NJ, Jones S, Wheelan SJ, Papadopoulos N, Vogelstein B, Kinzler KW, Hruban RH, Klein AP, Eshleman JR. Familial and sporadic pancreatic cancer share the same molecular pathogenesis. Fam Cancer. 2015 Mar;14(1):95-103.
  20. Pea A, Hruban RH, Wood LD. Genetics of pancreatic neuroendocrine tumors: implications for the clinic. Expert Rev Gastroenterol Hepatol 2015;9(11):1407-19.
  21. Pittman ME, Brunt EM. Anatomic pathology of hepatocellular carcinoma: histopathology using classic and new diagnostic tools. Clin Liver Dis. 2015 May;19(2):239-59.
  22. Pittman ME, Montgomery EA. Distinctive clinicopathologic featuresof the common myxoid soft tissue lesions. Diagnostic Histopathology 2015 Nov;21(11):438-44.
  23. Pittman ME, Voltaggio L, Bhaijee F, Robertson SA, Montgomery EA. Autoimmune metaplastic atrophic gastritis: recognizing precursor lesions for appropriate patient evaluation. Am J Surg Pathol. 2015 Dec;39(12):1611-20.
  24. Rishi A, Goggins M, Wood LD, Hruban RH. Pathological and molecular evaluation of pancreatic neoplasms. Semin Oncol. 2015 Feb;42(1):28-39.
  25. Roberts NJ, Wolfgang CL, Wood LD, Zandi PP, Goggins M, Karchin R, Eshleman JR, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH, Klein AP. Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer. Cancer Discov. 2016 Feb;6(2):166-75.
  26. Singhi AD, Ishida H, Ali SZ, Goggins M, Canto M, Wolfgang CL, Meriden Z, Roberts N, Klein AP, Hruban RH. A histomorphologic comparison of familial and sporadic pancreatic cancers. Pancreatology 2015 July-Aug;15(4):387-91.
  27. Voltaggio L, Montgomery E. Gastrointestinal tract spindle cell lesions-just like real estate, it’s all about location. Mod Pathol. 2015 Jan;28 Suppl 1:S47-66.
  28. Voltaggio L, Montgomery E. Polypoid stromal lesions of the intestines. Histopathology. 2015 Jan;66(1):88-101.
  29. Wood LD, Hruban RH. Genomic landscapes of pancreatic neoplasia. J Pathol Transl Med. 2015 Jan;49(1):13-22.
  30. Yu J, Blackford A, dal Molin M, Wolfgang CL, Goggins M. Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages. Gut. 2015 Nov;64(11):1783-9.

2014 Annual Report +
  1. Ali MA, Arnold CA, Singhi AD, Voltaggio L. Clues to uncommon and easily overlooked infectious diagnoses affecting the GI tract and distinction from their clinicopathologic mimics. Gastrointest Endosc. 2014 Oct;80(4):689-706.
  2. Chen G, Mosier S, Gocke CD, Lin MT, Eshleman JR. Cytosine deamination is a major cause of baseline noise in next-generation sequencing. Mol Diagn Ther 2014 Oct;18(5):587-93.
  3. Debeljak M, Freed DN, Welch JA, Haley L, Beierl K, Iglehart BS, Pallavajjala A, Gocke CD, Leffell MS, Lin MT, Pevsner J, Wheelan SJ, Eshleman JR. Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection. J Molec Diagn 2014 Sept;16(5):495-503.
  4. Gurda GT, Zhu Q, Bai H, Pan D, Schwarz KB, Anders RA. The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease. Hum Pathol. 2014 May;45(5):1057-64.
  5. Jiao Y, Yonescu R, Offerhaus GJ, Klimstra DS, Maitra A, Eshleman JR, Herman JG, Poh W, Pelosof L, Wolfgang CL, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N, Wood LD. Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. J Pathol 2014 Mar;232(4):428-35.
  6. Kim H, Saka B, Knight S, Borges M, Childs E, Klein AP, Wolfgang CL, Herman JM, Adsay V, Hruban RH, Goggins M. Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis. Clin Cancer Res 2014 Apr 1;20(7):1865-72.
  7. Le A, Stine ZE, Nguyen C, Afzal J, Sun P, Hamaker M, Siegel NM, Gouw AM, Kang BH, Yu SH, Cochran RL, Sailor KA, Song H, Dang CV. Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter. Proc Natl Acad Sci U S A. 2014;111(34):12486-91.
  8. Lennon AM, Wolfgang CL, Canto EK, Kamel I, Weiss MJ, Diaz LA, Papdopoulos N, Kinzler KW, Vogelstein B, Hruban RH. The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? Cancer Res July 2014;74:3381.
  9. Lin MT, Mosier SL, Thiess M, Beierl KF, Debeljak M, Tseng LH, Chen G, Yegnasubramanian S, Ho H, Cope L, Wheelan SJ, Gocke CD, Eshleman JR. Clinical Validation of KRAS, BRAF and EGFR Mutation Detection using Next Generation Sequencing. Am J Clin Pathol 2014 June;141(6):856-66.
  10. Ma C, Giardiello FM, Montgomery EA. Upper tract juvenile polyps in juvenile polyposis patients: dysplasia and malignancy are associated with foveolar, intestinal, and pyloric differentiation. Am J Surg Pathol 2014 Dec;38(12):1618-26.
  11. Ma C, Limketkai BN, Montgomery EA. Recently highlighted non-neoplastic pathologic entities of the upper GI tract and their clinical significance. Gastrointest Endosc. 2014 Dec;80(6):960-9.
  12. Matthaei H, Wu J, Dal Molin M, Shi C, Perner S, Kristiansen G, Lingohr P, Kalff JC, Wolfgang CL, Kinzler KW, Vogelstein B, Maitra A, Hruban RH. GNAS Sequencing Identifies IPMN-specific Mutations in a Subgroup of Diminutive Pancreatic Cysts Referred to as "Incipient IPMNs". Am J Surg Pathol 2014 Mar;38(3):360-3.
  13. McCall CM, Mosier S, Thiess M, Debeljak M, Pallavajjala A, Beierl K, Deak KL, Datto MB, Gocke CD, Lin MT, Eshleman JR. False positives in multiplex PCR-based next-generation sequencing have unique signatures. J Mol Diagn 2014 Sep;16(5):541-9.
  14. Montgomery E, Voltaggio L. Mesenchymal polyps. Diagn Histopathol 2014 Jan;20(1):19-29.
  15. Montgomery E, Voltaggio L, Vieth M. Inflammation, malignancy and immunology in gastrointestinal spindle cell tumors: what is beyond GIST?. Pathologe. 2014 Nov;35 Suppl 2:207-13.
  16. Piwowar-Manning E, Fogel JM, Laeyendecker O, Wolf S, Cummings V, Marzinke M, Clarke W, Breaud A, Wendel S, Wang L, Swanson P, Hackett J, Jr., Mannheimer S, del Rio C, Kuo I, Harawa NT, Koblin BA, Matthaei H, Wu J, dal Molin M, Shi C, Perner S, Kristiansen G, Lingohr P, Klaff JC, Wolfgang CL, Kinzler KW, Vogelstein B, Maitra A, Hruban RH. GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "Incipient IPMNs." Am J Surg Pathol 2014 Mar;38(3):360-3
  17. Rodriguez E, Tellschow S, Steinberg DM, Montgomery E. Cytologic findings of gastric schwannoma: a case report. Diagn Cytopathol 2014 Feb;42(2):177-80.
  18. Sadakari Y, Kanda M, Maitani K, Borges M, Canto MI, Goggins M. Mutant KRAS and GNAS DNA concentrations in secretin-stimulated pancreatic fluid collected from the pancreatic duct and the duodenal lumen. Clin Transl Gastroenterol 2014 Nov;5:e62.
  19. Singhi AD, Arnold CA, Crowder CD, Lam-Himlin DM, Voltaggio L, Montgomery EA. Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients. Modern Pathol 2014 Jan;27:38-43.
  20. Slavik T, Montgomery EA. Cronkhite-Canada syndrome six decades on: the many faces of an enigmatic disease. J Clin Pathol. 2014 Oct;67(10):891-7.
  21. Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, Chen L, Pardoll DM, Topalian SL, Anders RA. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti–PD-1 therapy. Clin Cancer Res Oct 2014;20:5064.
  22. Vieth M, Montgomery EA. Some observations on pyloric gland adenoma: an uncommon and long ignored entity! J Clin Pathol. 2014 Oct;67(10):883-90.
  23. Vieth M, Riddell RH, Montgomery EA. High-grade dysplasia versus carcinoma: east is east and west is west, but does it need to be that way? Am J Surg Pathol 2014 Nov;38(11):1453-6.
  24. Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, Van Seuningen I, Maitra A, Goggins M. Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth. Oncotarget. 2014 May 15;5(9):2575-87.
  25. Voltaggio L, Lam-Himlin D, Limketkai BN, Singhi AD, Arnold CA. Message in a bottle: decoding medication injury patterns in the gastrointestinal tract. J Clin Pathol 2014 Oct;67(10):903-12.
  26. Voltaggio L, Montgomery E. Gastric mesenchymal lesions other than gastrointestinal stromal tumor. Diagn Histopathol 2014 June;20(6):228-38.
  27. Wood LD. Update on Colorectal Polyps and Polyposis Syndromes. Diagn Histopathol. 2014 Jan;20:12-8.
  28. Wood LD, Klimstra DS. Pathology and genetics of pancreatic neoplasms with acinar differentiation. Semin Diagn Pathol. 2014 Nov;31(6):491-7.
  29. Wood LD, Salaria SN, Cruise MW, Giardiello FM, Montgomery EA. Upper GI tract lesions in familial adenomatous polyposis (FAP): enrichment of pyloric gland adenomas and other gastric and duodenal neoplasms. Am J Surg Pathol 2014 Mar;38(3):389-93.

2013 Annual Report +
  1. Dal Molin M, Matthaei H, Wu J, Blackford A, Debeljak M, Rezaee N, Wolfgang CL, Butturini G, Salvia R, Bassi C, Goggins MG, Kinzler KW, Vogelstein B, Eshleman JR, Hruban RH, Maitra A. Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Ann Surg Oncol 2013 Nov;20(12):3802-8.
  2. Harrington CT, Lin EI, Olson MT, Eshleman JR. Fundamentals of pyrosequencing. Arch Pathol Lab Med. 2013 Sep;137(9):1296-303.
  3. Jiao Y, Pawlik TM, Anders RA, Selaru FM, Streppel MM, Lucas DJ, Niknafs N, Guthrie VB, Maitra A, Argani P, Offerhaus GJA, Roa JC, Roberts LR, Gores GJ, Popescu I, Alexandrescu ST, Dima S, Fassan M, Simbolo M, Mafficini A, Capelli P, Lawlor RT, Ruzzenente A, Guglielmi A, TortoraG, de Braud F, Scarpa A, Jarnagin W, Klimstra D, Karchin R, Velculescu VE, Hruban RH, Vogelstein B, Kinzler KW, Papadopoulos N, Wood LD. Exome sequencing reveals frequent inactivating mutations in BAP1, ARID1A, and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet 2013 Dec;45(12):1470-3.
  4. Kamiyama H, Rauenzahn S, Shim JS, Karikari CA, Feldmann G, Hua L, Kamiyama M, Schuler FW, Lin MT, Beaty RM, Karanam B, Liang H, Mullendore ME, Mo G, Hidalgo M, Jaffee E, Hruban RH, Jinnah HA, Roden RB, Jimeno A, Liu JO, Maitra A, Eshleman JR. Personalized chemotherapy profiling using cancer cell lines from selectable mice. Clin Cancer Res 2013 Mar 1;19(5):1139-46.
  5. Kanda M, Knight S, Topazian M, Syngal S, Farrell J, Lee J, Kamel I, Lennon AM, Borges M, Young A, Fujiwara S, Seike J, Eshleman J, Hruban RH, Canto MI, Goggins M. Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts. Gut 2013 Jul;62(7):1024-33.
  6. Kanda M, Sadakari Y, Borges M, Topazian M, Farrell J, Syngal S, Lee J, Kamel I, Lennon AM, Knight S, Fujiwara S, Hruban RH, Canto MI, Goggins M. Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. Clin Gastroenterol Hepatol 2013 Jun;11(6):719-30.e5
  7. Le A, Dang CV. Studying Myc's role in metabolism regulation. Methods Mol Biol 2013;1012:213-9.
  8. Lewis GH, Wang H, Bellizzi AM, Klein AP, Askin FB, Schwartz LE, Schulick RD, Wolfgang CL, Cameron CL, O'Reilly EM, Yu KH, Hruban RH. Prognosis of minimally invasive carcinoma arising in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 2013 Apr;37(4):601-5.
  9. Li A, Yu J, Kim H, Wolfgang CL, Canto MI, Hruban RH, Goggins M. MicroRNA array analysis finds elevated serum miR-1290 accurately distinguishes patients with low-stage pancreatic cancer from healthy and disease controls. Clin Cancer Res 2013 Jul 1;19(13):3600-10.
  10. Lin J, Bigge J, Ulbright TM, Montgomery E. Anastomosing hemangioma of the liver and gastrointestinal tract: an unusual variant histologically mimicking angiosarcoma. Am J Surg Pathol 2013 Nov;37(11):1761-5.
  11. Macgregor-Das AM, Iacobuzio-Donahue CA. Molecular pathways in pancreatic carcinogenesis. J Surg Oncol 2013 Jan;107(1):8-14.
  12. Makohon-Moore A, Iacobuzio-Donahue CA. Considerations for sequencing analyses of pancreatic cancer progression and metastasis. Methods Mol Biol 2013;980:121-9.
  13. Matthaei H, Dal Molin M, Maitra A. Identification and analysis of precursors to invasive pancreatic cancer. Methods Mol Biol 2013;980:1-12.
  14. McCall CM, Shi C, Cornish TC, Klimstra DS, Tang LH, Basturk O, Mun LJ, Ellison TA, Wolfgang CL, Choti MA, Schulick RD, Edil BH, Hruban RH. Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate. Am J Surg Pathol 2013 Nov;37(11):1671-7.
  15. Robertson S, Hyder O, Dodson R, Nayar SK, Poling J, Beierl K, Eshleman JR, Lin MT, Pawlik TM, Anders RA. The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome. Hum Pathol 2013 Dec;44(12):2768-73.
  16. Salaria SN, Abu Alfa AK, Cruise MW, Wood LD, Montgomery EA. Lichenoid esophagitis: clinicopathologic overlap with established esophageal lichen planus. Am J Surg Pathol 2013 Dec;37(12):1889-94.
  17. Sharma P, Montgomery E. Gastrointestinal dysplasia. Pathology JRCPA Apr 2013;45(3):273-85.
  18. Singhi AD, Norwood S, Liu TC, Sharma R, Wolfgang CL, Schulick RD, Zeh HJ, Hruban RH. Acinar cell cystadenoma of the pancreas: a benign neoplasm or non-neoplastic ballooning of acinar and ductal epithelium? Am J Surg Pathol 2013 Sep;37(0):1329-35.
  19. Streppel MM, Pai S, Campbell NR, Hu C, Yabuuchi S, Canto MI, Wang JS, Montgomery EA, Maitra A. MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. Clin Cancer Res 2013 Aug 1;19(15):4067-78.
  20. Wolfgang CL, Herman JM, Laheru DA, Klein AP, Erdek MA, Fishman EK, Hruban RH. Recent progress in pancreatic cancer. CA cancer J Clin 2013 Sep;63(5):318-48.
  21. Wood LD. Pancreatic cancer genomes: toward molecular subtyping and novel approaches to diagnosis and therapy. Mol Diagn Ther 2013 Oct;17(5):287-97.
  22. Wood LD, Heaphy CM, Daniel HJ, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove D, Boitnott J, Meeker AK, Torbenson M. Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphologic and molecular features. Mod Pathol 2013 Dec; 26(12):1586-93.
  23. Yabuuchi S, Pai SG, Campbell NR, de Wilde RF, De Oliveira E, Korangath P, Streppel MM, Rasheed ZA, Hidalgo M, Maitra A, Rajeshkumar NV. Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer. Cancer Lett 2013 Jul 10;335(1):41-51.
  24. Yachida S, Iacobuzio-Donahue CA. Evolution and dynamics of pancreatic cancer progression. Oncogene. 2013 Nov 7;32(45):5253-60.
  25. Yegnasubramanian S, Maitra A. Aiming for the outliers: cancer precision medicine through targeting kinases with extreme expression. Cancer Discov 2013 Mar;3(3):252-4.

2012 Annual Report +
  1. Arnold CA, Moreira RK, Lam-Himlin D, De Petris G, Montgomery E. Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. Am J Surg Pathol 2012 Jul;36(7):1066-73.
  2. Bai H, Gayyed MF, Lam-Himlin DM, Klein AP, Nayar SK, Xu Y, Khan M, Argani P, Pan D, Anders RA. Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies. Hum Pathol 2012 Sep;43(9):1376-85.
  3. Bai H, Zhang N, Xu Y, Chen Q, Khan M, Potter JJ, Nayar SK, Cornish T, Alpini G, Bronk S, Pan D, Anders RA. Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology 2012 Sep;56(3):1097-107
  4. Brosnan JA, Iacobuzio-Donahue CA. A new branch on the tree: next-generation sequencing in the study of cancer evolution. Semin Cell Dev Biol 2012 Apr;23(2):237-42.
  5. Canto MI, Hruban RH, Fishman EK, Kamel IR, Schulick R, Zhang Z, Topazian M, Takahashi N, Fletcher J, Petersen G, Klein AP, Axilbund J, Griffin C, Syngal S, Saltzman JR, Mortele KJ, Lee J, Tamm E, Vikram R, Bhosale P, Margolis D, Farrell J, Goggins M. Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. Gastroenterology 2012 Apr;142(4):796-804.
  6. Chen G, Olson MT, O'Neill AO, Norris A, Beierl K, Harada S, Debeljak M, Rivera-Roman K, Finley S, Stafford A, Gocke CD, Lin MT, Eshleman JR. A virtual pyrogram generator to resolve complex pyrosequencing results. J Mol Diagn 2012 Mar;14:149-59.
  7. Chenna V, Hu C, Pramanik D, Aftab BT, Karikari C, Campbell NR, Hong SM, Zhao M, Rudek MA, Khan SR, Rudin CM, Maitra A. A polymeric nanoparticle encapsulated small-molecule inhibitor of hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to smoothened antagonists. Mol Cancer Ther 2012 Jan;11(1):165-73.
  8. Crane CH, Iacobuzio-Donahue CA. Keys to personalized care in pancreatic oncology. J Clin Oncol 2012 Nov 20;30(33):4049-950.
  9. Cui Y, Brosnan JA, Blackford AL, Sur S, Hruban RH, Kinzler KW, Vogelstein B, Maitra A, Diaz LA Jr, Iacobuzio-Donahue CA, Eshleman JR. Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity. Clin Cancer Res 2012 Dec 1;18(23):6519-30
  10. Fu B, Yachida S, Morgan R, Zhong Y, Montgomery EA, Iacobuzio-Donahue CA. Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon. Am J Clin Pathol 2012 Sep;138(3):356-66.
  11. Gupta S, Pramanik D, Mukherjee R, Campbell NR, Elumalai S, de Wilde RF, Hong SM, Goggins MG, De Jesus-Acosta A, Laheru D, Maitra A. Molecular determinants of retinoic acid sensitivity in pancreatic cancer. Clin Cancer Res 2012 Jan 1;18(1):280-9.
  12. Hong SM, Omura N, Vincent A, Li A, Knight S, Yu J, Hruban RH, Goggins M. Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res. 2012 Feb;18(3):700-12.
  13. Hong SM, Vincent A, Kanda M, Leclerc J, Omura N, Borges M, Klein AP, Canto MI, Hruban RH, Goggins M. Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer. Clin Cancer Res 2012 Aug 15;18(16):4303-12.
  14. Iacobuzio-Donahue CA. Personalized medicine in pancreatic cancer: prognosis and potential implications for therapy. J Gastrointest Surg 2012 Sep;16(9):1651-2.
  15. Iacobuzio-Donahue CA, Velculescu VE, Wolfgang CE, Hruban RH. Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing. Clin Cancer Res 2012 Aug 15;18(16):4257-65.
  16. Kanda M, Matthaei H, Wu J, Hong SM, Yu J, Borges M, Hruban RH, Maitra A, Kinzler K, Vogelstein B, Goggins M. Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterol 2012 Apr;142(4):730-3.
  17. Le A, Lane NA, Hamaker M, Bose S, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos R, Lorkiewicz P, Higashi RM, Fan WMT, Dang CV. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in human B lymphocytes. Cell Metab. 2012 Jan 4;15(1):110-21.
  18. Le A, Rajeshkumar NV, Maitra A, Dang CV. Conceptual framework for cutting the pancreatic cancer fuel supply. Clin Cancer Res 2012 Aug;18(16):4285-90.
  19. Liu TC, Nguyen TT, Torbenson MS. Concurrent increase in mitosis and apoptosis: a histological pattern of hepatic arterial flow abnormalities in post-transplant liver biopsies. Mod Pathol 2012 Dec;25(12):1594-8.
  20. Maitra A, Leach SD. Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia. Cancer Cell 2012 Dec;22(6):701-3.
  21. Matsukuma KE, Montgomery EA. Tubular carcinoids of the appendix: the CK7/CK20 immunophenotype can be a diagnostic pitfall. J Clin Pathol 2012 Jul;65(7):666-8
  22. Matthaei H, Norris-Kirby A, Tsiatis AC, Olino K, Hong SM, dal Molin M, Goggins M, Canto M, Horton KM, Jackson KD, Capelli P, Zamboni G, Bortesi L, Furukawa T, Egawa S, Ishida M, Ottomo S, Unno M, Motoi F, Wolfgang CL, Edil BH, Cameron JL, Eshleman JR, Schulick RD, Maitra A, Hruban RH. Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas. Ann Surg 2012 Feb;255(2):326-33.
  23. Matthaei H, Wu J, Dal Molin M, Debeljak M, Lingohr P, Katabi N, Klimstra DS, Adsay NV, Eshleman JR, Schulick RD, Kinzler KW, Vogelstein B, Hruban RH, Maitra A. GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct. HPB (Oxford) 2012 Oct;14(10):677-83.
  24. Matthaei H, Wylie D, Lloyd MB, Dal Molin M, Kemppainen J, Mayo SC, Wolfgang CL, Schulick RD, Langfield L, Andruss BF, Adai AT, Hruban RH, Szafranska-Schwarzbach AE, Maitra A. miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts. Clin Cancer Res. 2012 Sep 1;18(17):4713-24.
  25. McDonald OG, Maitra A, Hruban RH. Human correlates of provocative questions in pancreatic pathology. Adv Anat Pathol 2012 Nov;19(6):351-62.
  26. Mizuma M, Rasheed ZA, Yabuuchi S, Omura N, Campbell NR, de Wilde RF, De Oliveira E, Zhang Q, Puig O, Matsui W, Hidalgo M, Maitra A, NV RK.. The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. Mol Cancer Ther. 2012 Sep;11(9):1999-2009
  27. Montgomery E, Voltaggio L, Canto MI. Much ado about very little (lamina propria)? Gastrointest Endosc 2012 Jan;75(1):19-22.
  28. Pramanik D, Campbell NR, Das S, Gupta S, Chenna V, Bisht S, Sysa-Shah P, Bedja D, Karikari C, Steenbergen C, Gabrielson KL, Maitra A, Maitra A. A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy. Oncotarget 2012 Jul;3(6):640-50
  29. Salaria SN, Streppel MM, Lee LA, Iacobuzio-Donahue CA, Montgomery EA. Sessile serrated adenomas: high-risk lesions? Hum Pathol 2012 Nov;43(11):1808-14.
  30. Singhi AD, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson M. Reticulin loss in benign fatty liver: an important diagnostic pitfall when considering a diagnosis of hepatocellular carcinoma. Am J Surg Pathol. 2012 May;36(5):710-5.
  31. Singhi AD, Lazenby AJ, Montgomery EA. Gastric adenocarcinoma with chief cell differentiation: a proposal for reclassification as oxyntic gland polyp/adenoma. Am J Surg Pathol 2012 Jul;36(7):1030-5.
  32. Streppel MM, Vincent A, Mukherjee R, Campbell NR, Chen SH, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA. Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon. Hum Pathol 2012 Oct;43(10):1755-63.
  33. Wood LD, Hruban RH. Pathology and molecular genetics of pancreatic neoplasms. Cancer J 2012 Nov;18 (6):492-501.
  34. Xu Y, Chenna V, Hu C, Sun HX, Khan M, Bai H, Yang XR, Zhu QF, Sun YF, Maitra A, Fan J, Anders RA. Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (nanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma. Clin Cancer Res 2012 Mar 1;18(5):1291-302.
  35. Yachida S, Vakiani E, White CM, Zhong Y, Saunders T, Morgan R, de Wilde RF, Maitra A, Hicks J, Demarzo AM, Shi C, Sharma R, Laheru D, Edil BH, Wolfgang CL, Schulick RD, Hruban RH, Tang LH, Klimstra DS, Iacobuzio-Donahue CA. Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am J Surg Pathol 2012 Feb;36(2):173-84.
  36. Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, Velculescu V, Wolfgang CL, Iacobuzio-Donahue CA. Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Clin Cancer Res 2012 Nov;18(22):6339-47.
  37. Yu J, Li A, Hong SM, Hruban RH, Goggins M. MicroRNA alterations of pancreatic intraepithelial neoplasias. Clin Cancer Res 2012 Feb;18(4):981-92.
  38. Yu J, Walter K, Omura N, Hong S-M, Young A, Li A, Vincent A, Goggins M. Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2'-deoxycytidine. PLoS One 2012 Sept;7(9):e43456.

2011 Annual Report +
  1. Bisht S, Mizuma M, Feldmann G, Ottenhof NA, Hong SM, Pramanik D, Chenna V, Karikari C, Sharma R, Goggins MG, Rudek MA, Ravi R, Maitra A, Maitra A. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther 2010 Aug;9(8):2255-64.
  2. Goggins M. Markers of pancreatic cancer: working toward early detection. Clin Cancer Res 2011 Feb 15;17(4):635-7.
  3. Handra-Luca A, Montgomery E. Vascular malformations and hemangiolymphangiomas of the gastrointestinal tract: morphological features and clinical impact. Int J Clin Exp Pathol 2011 Jun 20;4(5):430-43.
  4. Hong SM, Heaphy CM, Shi C, Eo SH, Cho H, Meeker AK, Eshleman JR, Hruban RH, Goggins M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod Pathol 2011 Feb;24(2):256-66.
  5. Lam-Himlin D, Arnold CA, Montgomery EA. Histopathology of Iatrogenic injury in the colorectum. Diagnostic Histopathology 2011 Sept;17(9):404-8.
  6. Lam-Himlin D, Montgomery EA. The neoplastic appendix: a practical approach. Diagnostic Histopathology 2011;17(9):395-403.
  7. Lam-Himlin D, Tsiatis AC, Montgomery E, Pai RK, Brown JA, Razavi M, Lamps L, Eshleman JR, Bhagavan B, Anders RA. Sarcina organisms in the gastrointestinal tract: a clinicopathologic and molecular study. Am J Surg Pathol. 2011 Nov;35(11):1700-5.
  8. Matsubayashi H, Hasuike N, Onozawa Y, Knemoto H, Ono H, Hruban RH. Autoimmune pancreatitis with response to chemoradiation therapy. J Gastrointestin Liver Dis 2011 Sept;3:315-9.
  9. Matthaei H, Schulick RD, Hruban RH, Maitra A. Cystic precursors to invasive pancreatic cancer. Nat Rev Gastroenterol Hepatol 2011 Mar;8(3):141-50.
  10. Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, Schulick RD, Hruban RH. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol. 2011 Jul;35(7):981-8.
  11. Montgomery E. Pattern approach to soft tissue tumors. Clinics in Surgical Pathol 2011 Sept;4(3):ix.
  12. Pramanik D, Campbell NR, Karikari C, Chivukula R, Kent OA, Mendell JT, Maitra A. Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Mol Cancer Ther 2011 Aug;10(8):1470-80.
  13. Ross HM, Daniel HD, Vivekanandan P, Kannangai R, Yeh MM, Wu TT, Makhlouf HR, Torbenson M. Fibrolamellar carcinomas are positive for CD68. Mod Pathol 2011 Mar;24(3):390-5.
  14. Ryu JK, Matthaei H, Dal Molin M, Hong SM, Canto MI, Schulick RD, Wolfgang C, Goggins MG, Hruban RH, Cope L, Maitra A. Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma. Pancreatology 2011 Sept;11(3):343-50.
  15. Salih KH, Singhi AD, Montgomery E. Selected lesions featuring giant cells. Clinics in Surgical Pathol 2011Sept;4:887-913.
  16. Singhi AD, Maklouf HR, Mehrotra AK, Goodman ZD, Drebber U, Dienes HP, Torbenson M. Segmental atrophy of the liver: a distinctive pseudotumor of the liver with variable histologic appearances. Am J Surg Pathol 2011 Mar;35(3):364-71.
  17. Singhi AD, Montgomery EA. Gastrointestinal tract langerhans cell histiocytosis: a clinicopathologic study of 12 patients. Am J Surg Pathol 2011 Feb;35(2):305-10.
  18. Singhi AD, Montgomery E. Liposarcomas. Clinics in Surgical Pathol 2011 Sept;4:963-94.
  19. Torbenson, MS. Iron in the liver: A review for surgical pathologists. Adv Anat Pathol. 2011 Jul;18(4):306-17.
  20. Voltaggio L, Montgomery EA. Histopathology of Barrett esophagus. Diagnostic Histopathology 2011;17(2):41-9.
  21. Yachida S, Zhong Y, Patrascu R, Davis MB, Morsberger LA, Griffin CA, Hruban RH, Laheru D, Iacobuzio-Donahue CA. Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas. Pancreas 2011 Aug;40(6):905-10.
  22. Zhong Y, Wang Z, Fu B, Pan F, Yachida S, Dhara M, Albesiano E, Li L, Naito Y, Vilardell F, Cummings C, Martinelli P, Li A, Yonescu R, Ma Q, Griffin CA, Real FX, Iacobuzio-Donahue CA. GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist dickkopf-1. PLoS One 2011;6(7):e22129.
  23. Zulifqar MI, Sheikh U, Montgomery E. Myxoid neoplasms. Clinics in Surgical Pathol 2011Sept;4:843-64.

2010 Annual Report +
  1. Bisht S, Mizuma M, Feldmann G, Ottenhof NA, Hong SM, Pramanik D, Chenna V, Karikari C, Sharma R, Goggins MG, Rudek MA, Ravi R, Maitra A, Maitra A. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther 2010 Aug;9(8):2255-64.
  2. Hector A, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM, Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa JC, Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A. The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma. Cancer Biol Ther 2010 Nov 29;10(10):1009-18.
  3. Kamiyama H, Kamiyama M, Hong SM, Karikari CA, Lin MT, Borges MW, Griffith M, Young A, Norris-Kirby A, Lubek C, Mizuma M, Feldmann G, Shi C, Liang H, Goggins MG, Maitra A, Hruban RH, Eshleman JR. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab Invest. 2010 May;90(5):665-73.
  4. Lam-Himlin D, Park JY, Cornish TC, Shi C, Montgomery E. Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol 2010 Nov;34(11):1656-62.
  5. Lennon AM, Klein AP, Goggins M. ABO blood group and other genetic variants associated with pancreatic cancer. Genome Med. 2010 Jun 22;2(6):39.
  6. Li A, Omura N, Hong SM, Vincent A, Walter K, Griffith M, Borges M, Goggins M. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res 2010 Jul 1;70(13):5226-37.
  7. Maitra A. Tracking down the hedgehog's lair in the pancreas. Gastroenterology 2010 Mar;138(3):823-5.
  8. Montgomery E. Colorectal polyps: sporadic and syndromic. Int J Surg Pathol 2010 Jun;18(3 Suppl):56S-61S.
  9. Montgomery E. Small-intestinal pathology: topics and pitfalls. Int J Surg Pathol 2010 Jun;18(3 Suppl):37S-42S.
  10. Omura N, Griffith M, Vincent A, Li A, Hong SM, Walter K, Borges M, Goggins M. Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins. Mol Cancer Res 2010 Jun;8(6):821-32.
  11. Park JY, Cornish TC, Lam-Himlin D, Shi C, Montgomery E. Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am J Surg Pathol 2010 Nov;34(11):1591-8.
  12. Ryu JK, Hong SM, Karikari CA, Hruban RH, Goggins MG, Maitra A. Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology 2010 Apr;10(1):66-73.
  13. Shi C, Scudiere JR, Cornish TC, Lam-Himlin D, Park JY, Fox MR, Montgomery EA. Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. Am J Surg Pathol 2010 Sep;34(9):1344-50.
  14. Shi C, Siegelman SS, Kawamoto S, Wolfgang CL, Schulick RD, Maitra A, Hruban RH. Pancreatic duct stenosis secondary to small endocrine neoplasms: a manifestation of serotonin production? Radiology 2010 Oct;257(1):107-14.
  15. Shin DH, Lee JH, Kang HJ, Choi KU, Kim JY, Park do Y, Lee CH, Sol MY, Park JH, Kim HY, Montgomery E. Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings. J Clin Pathol 2010 Mar;63(3):270-4.
  16. Singhi AD, Montgomery EA. Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol 2010 Aug;34(8):1186-92.
  17. Yachida S, Imaida K, Yokohira M, Hashimoto N, Suzuki S, Okano K, Wakabayashi H, Maeta H, Suzuki Y. Jun activation domain binding protein 1 is overexpressed from the very early stages of hepatocarcinogenesis. Ann Surg Oncol 2010 Dec;17:3386-93.
  18. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010 Oct;467(7319):1114-7.
  19. Walter K, Omura N, Hong SM, Griffith M, Vincent A, Borges M, Goggins M. Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Clin Cancer Res 2010 Mar;16(6):1781-9.

2009 Annual Report +
  1. Anders RA, Montgomery E, Maitra A. Johns Hopkins course: 8th annual Current Topics in Gastrointestinal and Liver Pathology. Expert Rev Gastroenterol Hepatol 2009 Feb;3(1):33-7.
  2. Bisht S, Maitra A. Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Curr Drug Discov Technol 2009 Sep;6(3):192-9.
  3. Blackford A, Serrano OK, Wolfgang C, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res 2009 Jul 15;15(14):4674-9
  4. Chen ZM, Scudiere JR, Abraham SC, Montgomery E. Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. Am J Surg Pathol 2009 Feb;33(2):186-93.
  5. Chen Z, Scudiere JR, Montgomery E. Medication-induced upper gastrointestinal tract injury. J Clin Pathol 2009 Feb;62(2):113-9.
  6. Chetty R, Hafezi S, Montgomery E. An incidental enterocolic lymphocytic phlebitis pattern is seen commonly in the rectal stump of patients with diversion colitis superimposed on inflammatory bowel disease. J Clin Pathol 2009 May;62(5):464-7.
  7. Hidalgo M, Maitra A. The hedgehog pathway and pancreatic cancer. N Engl J Med 2009 Nov;361(21):2094-6.
  8. Hong SM, Pawlik TM, Cho H, Aggarwal B, Goggins M, Hruban RH, Anders RA. Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma. Surgery 2009 Aug;146(2):250-7.
  9. Hristov AC, Cope L, Reyes MD, Singh M, Iacobuzio-Donahue C, Maitra A, Resar LM. HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Mod Pathol 2009 Jan;22(1):43-9.
  10. Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol 2009 Apr 10;27(11):1806-13.
  11. Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JC, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, Kinzler KW, Vogelstein B, Eshleman JR, Klein AP*, Goggins M* (joint senior authors). Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009 Apr;324(5924):217.
  12. Klein AP, Borges M, Griffith M, Brune K, Hong SM, Omura N, Hruban RH, Goggins M. Absence of deleterious palladin mutations in patients with familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2009 Apr;18(4):1328-30.
  13. Koorstra JB, Hong SM, Shi C, Meeker AK, Ryu JK, Offerhaus GJ, Goggins MG, Hruban RH, Maitra A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod Pathol 2009 Nov;22(11):1439-45.
  14. Koorstra JB, Karikari CA, Feldmann G, Bisht S, Rojas PL, Offerhaus GJ, Alvarez H, Maitra A. The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target. Cancer Biol Ther 2009 Apr;8(7):618-26.
  15. Lee KH, Lotterman C, Karikari C, Omura N, Feldmann G, Habbe N, Goggins MG, Mendell JT, Maitra A. Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology 2009 May;9(3):293-301.
  16. Montgomery RA, Locke JE, King KE, Segev DL, Warren DS, Kraus ES, Cooper M, Simpkins CE, Singer AL, Stewart ZA, Melancon JK, Ratner L, Zachary AA, Haas M. ABO incompatible renal transplantation: a paradigm ready for broad implementation. Transplantation 2009 April;87(8):1246-55.
  17. Montgomery E, Dunbar K. A Pathologic Love Letter. AGA Perspectives 2009 April/May;5(2):10-11.
  18. Mullendore ME, Koorstra JB, Li YM, Offerhaus GJ, Fan X, Henderson CM, Matsui W, Eberhart CG, Maitra A, Feldmann G. Ligand-dependent notch signaling is involved intumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res 2009 April;15(7):2291-301.
  19. Nguyen T, Park JY, Scudiere JR, Montgomery E. Mycophenolic acid (cellcept and myofortic) induced injury of the upper GI tract. Am J Surg Pathol 2009 Sep;33(9):1355-63.
  20. Samet JD, Horton KM, Fishman EK, Iacobuzio-Donahue CA. Cronkhite-Canada Syndrome: gastric involvement diagnosed by MDCT. Case Report Med. 2009;2009:148795.
  21. Scudiere JR, Maitra A, Montgomery EA. Selected topics in the evaluation of pediatric gastrointestinal mucosal biopsies. Adv Anat Pathol 2009 May;16(3):154-60.
  22. Scudiere JR, Montgomery EA. New treatments, new challenges: pathology's perspective on esophageal carcinoma. Gastroenterol Clin North Am 2009 Mar;38(1):121-33.
  23. Shi C, Chandrasekharan A, Thuluvath PJ, Karikari C, Argani P, Goggins M, Maitra A, Eshleman JR. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Molec Diagnostics 2009 Nov;11:583-9.
  24. Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, Goggins M, Hruban RH, Eshleman JR. KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res 2009 Feb;7(2):230-6.
  25. Tumanov AV, Koroleva EP, Christiansen PA, Khan MA, Ruddy MJ, Burnette B, Papa S, Franzoso G, Nedospasov SA, Fu YX, Anders RA. T cell-derived lymphotoxin regulates liver regeneration. Gastroenterology 2009 Feb;136(2):694-704.e4.
  26. Wheeler YY, Wheeler GL, Diaz-Arias AA, Anders RA. Metastatic renal cell carcinoma within a hepatic focal nodular hyperplasia: A case report and review of the literature. Int J Clin Exp Pathol 2009;2(2):190-3.
  27. Wu JM, Alvarez H, Garcia P, Rojas PL, Wong G, Maitra A, Antonescu C, Montgomery EA. Melanoma hyperpigmentation is strongly associated with KIT protein over-expression. Am J Dermatopathol 2009 Oct;31:619-25.
  28. Yachida S, Iacobuzio-Donahue CA. The pathology and genetics of metastatic pancreatic cancer. Arch Pathol Lab Med. 2009 Mar;133(3):413-22.
  29. Yachida S, Mudali S, Martin SA, Montgomery EA, Iacobuzio-Donahue CA. Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation. Am J Surg Pathol 2009 Dec;33(12):1823-32.
  30. Yachida S, Tsutsui K, Suzuki Y. Minute gallbladder carcinoma associated with an anastomotic cholecystoduodenal fistula. Clin Gastroenterol Hepatol 2009 Feb;7(2):e6-7.
  31. Yachida S, Wakabayashi H, Okano K, SuzukiY. Prediction of posthepatectomy hepatic function reserve by serum hyaluronate. Br J Surg 2009 May;96(5):501-8.
  32. Yachida S, Wakabayashi H, Suzuki Y. Scirrhous hepatocellular carcinoma: unique computed tomography findings. Clin Gastroenterol Hepatol 2009 Jan;7(1):A28.
  33. Zou GM, Karikari C, Kabe Y, Handa H, Anders RA, Maitra A. The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis. J Cell Physiol 2009 Apr;219(1):209-18.

2008 Annual Report +
  1. Alvarez H, Corvalan A, Roa JC, Argani P, Murillo F, Edwards J, Beaty R, Feldmann G, Hong SM, Mullendore M, Roa I, Ibañez L, Pimentel F, Diaz A, Riggins GJ, Maitra A. Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer. Clin Cancer Res 2008 May 1;14(9):2631-8.
  2. Alvarez H, Leal Rojas P, Yong K-T, Ding H, Xu G, Prasad PN, Wang J, Canto M, Eshleman JR, Montgomery EA, Maitra A. Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: Translational implications for diagnosis and therapy. Nanomedicine 2008 Dec;4(4):295-301.
  3. Alvarez H, Koorstra J-BM, Hong S-M, Boonstra JJ, Dinjens WNM, Forastiere AA, Wu T-T, Montgomery E, Eshleman JR, Maitra A. Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line. Cancer Biol Ther 2008 Nov;7(11); 1753-5.
  4. Bisht S, Feldmann G, Koorstra JB, Mullendore M, Alvarez H, Karikari C, Rudek MA, Lee CK, Maitra Sr, A, Maitra A. In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities. Mol Cancer Ther 2008 Dec; 7(12):3878-88.
  5. Brune K, Hong SM, Li A, Yachida S, Abe T, Griffith M, Yang D, Omura N, Eshleman J, Canto M, Schulick R, Klein AP, Hruban RH, Iacobuzio-Donohue C, Goggins M. Genetic and epigenetic alterations of familial pancreatic cancers. Cancer Epidemiol Biomarkers Prev 2008 Dec;17(12):3536-42.
  6. Campagna D, Cope L, Lakkur SS, Henderson C, Laheru D, Iacobuzio-Donahue CA. Gene expression profiles associated with advanced pancreatic cancer. IJCEP 2008 Jan; 1(1):32-43.
  7. Chen TS, Montgomery EA. Are tumefactive lesions classified as sclerosing mesenteritis a subset of IgG4-related sclerosing disorders? J Clin Pathol 2008 Oct;61(10):1093-7.
  8. Cheung W, Darfler MM, Alvarez H, Hood BL, Conrads TP, Habbe N, Krizman DB, Mollenhauer J, Feldmann G, Maitra A. Application of a global proteomic approach to archival precursor lesions: deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancer precursors. Pancreatology 2008 Oct;8(6):608-16.
  9. Daniels JA, Gibson MK, Xu L, Sun S, Canto MI, Heath E, Wang J, Brock M, Montgomery E. Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect. Am J Surg Pathol 2008 Mar;32(3):473-7.
  10. Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, Koorstra JB, Habbe N, Karikari C, Mullendore M, Gabrielson KL, Sharma R, Matsui W, Maitra A. An orally bioavailable small-molecule inhibitor of hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther 2008 Sep;7(9):2725-35.
  11. Feldman G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C, Bardeesy N, Oullette MM, Yu W, Maitra A. Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut 2008 Oct;57:1420-30.
  12. Feldmann G, Maitra A. Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts. J Mol Diagn 2008 Mar;10(2):111-22.
  13. Fendrich V, Esni F, Garay V, Feldmann G, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD, Maitra A. Loss of acinar Hedgehog signaling impairs epithelial regeneration following exocrine pancreatic injury. Gastroenterology 2008 Aug;135(2):621-31.
  14. Fu B, Luo M, Lakkur S, Lucito R, Iacobuzio-Donahue CA. Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma. Cancer Biol Ther 2008 Oct;7(10):1593-601.
  15. Guler ML, Daniels JA, Abraham SC, Montgomery EA. Expression of melanoma antigens in epithelioid gastrointestinal stromal tumors: a potential diagnostic pitfall. Arch Pathol Lab Med 2008 Aug;132(8):1302-6.
  16. Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci USA 2008 Dec;105(48):18913-8.
  17. Hong SM, Kelly D, Griffith M, Omura N, Li A, Li CP, Hruban RH, Goggins M. Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas. Mod Pathol 2008 Dec;21(12):1499-507.
  18. Karanjawala ZE, Illei PB, Ashfaq R, Infante JR, Murphy K, Pandey A, Schulick R, Winter J, Sharma R, Maitra A, Goggins M, Hruban RH. New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8. Am J Surg Path 2008 Feb;32(2):188-96.
  19. Koorstra JB, Feldmann G, Habbe N, Maitra A. Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs). Langenbecks Arch Surg 2008 July;393:561-70.
  20. Koorstra JB, Hustinx SR, Offerhaus GJ, Maitra A. Pancreatic carcinogenesis. Pancreatology 2008 May;8(2):110-25.
  21. Laffan TA, Horton KM, Klein AP, Fishman EK, Johnson PT, Hruban RH. Prevalence of unsuspected pancreatic cysts on MDCT. AJR Am J Roentgenol 2008 Sep;191(3):802-7.
  22. Micchelli ST, Thomas D, Boitnott JK, Torbenson M. Hepatic giant cells in hepatitis C virus (HCV) mono-infection and HCV/HIV co-infection. J Clin Pathol 2008 Sep;61(9):1058-61.
  23. Micchelli ST, Vivekanandan P, Boitnott JK, Pawlik TM, Choti MA, Torbenson M. Malignant transformation of hepatic adenomas. Mod Pathol. 2008 Apr;21(4):491-7.
  24. Omura N, Li CP, Li A, Hong SM, Walter K, Jimeno A, Hidalgo M, Goggins M. Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma. Cancer Biol Ther 2008 Jul;7:1146-56.
  25. Parsi MA, Li A, Li CP, Goggins M. DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease. Clin Gastroenterol Hepatol 2008 Nov;6(11):1270-8.
  26. Qiu X, Montgomery E. Expression of EGFR in gastric stromal tumors: a clinicopathologic study. Appl Immunohistochem Mol Morphol 2008 Jul;16(4):310-5.
  27. Riddell R, Montgomery E. Burning issues in the stomach [Editorial]. Pathology Case Reviews 2008 Sept/Oct;13:155-6.
  28. Sato N, Fukushima N, Hruban RH, Goggins M. CpG island methylation profile of pancreatic intraepithelial neoplasia. Mod Pathol. 2008 Mar;21(3):238-44.
  29. Scudiere JR, Chen Z-M, Montgomery E. When sarcomas break the rules: evaluation of the CD117-negative gastrointestinal stromal tumor. Pathology Case Reviews 2008 Sept/Oct;13(5):203-9.
  30. Vivekanandan P, Kannangai R, Ray SC, Thomas DL, Torbenson M. Comprehensive genetic and epigenetic analysis of occult hepatitis B from liver tissue samples. Clin Infect Dis 2008 Apr ;46(8):1227-36.
  31. Vivekanandan P, Thomas D, Torbenson M. Hepatitis B viral DNA is methylated in liver tissues. J Viral Hepat. 2008 Feb;15(2):103-7.
  32. Vivekanandan P, Torbenson M. Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. Mod Pathol. 2008 Jun;21(6):670-5.
  33. Walter K, Omura N, Hong SM, Griffith M, Goggins M. Pancreatic cancer associated fibroblasts display normal allelotypes. Cancer Biol Ther 2008 June;7(6):882-8.
  34. Winter JM, Ting AH, Vilardell F, Gallmeier E, Baylin SB, Hruban RH, Kern SE, Iacobuzio-Donahue CA. Absence of e-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res 2008 Jan;14(2):412-8.v
  35. Witkiewicz AK, Kennedy EP, Kennyon L, Yeo CJ, Hruban RH. Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature. Hum Pathol 2008 Oct;39(10):1548-51.
  36. Wu JM, Montgomery E. Soft tissue sarcomas; Classification and pathology. Surg Clin North Am 2008 Jun;88(3):483-520.
  37. Wu JM, Montgomery EA, Iacobuzio-Donahue CA. Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential. Am J Clin Pathol 2008 Mar;129(3):416-23.
  38. Yachida S, Sakamoto M, Imaida K, Yokohira M, Saoo K, Okano K, Wakabayshi H, Maeta H, Suzuki Y. p27Kip1 is overexpressed in very early stages of hepatocarcinogenesis. Cancer Sci 2008 Nov;99(11):2152-9.
  39. Zou GM, Karikari C, Kabe Y, Handa H, Anders RA, Maitra A. The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor angiogenesis. J Cell Physiol. 2008 Dec 18; 219(1):209-18.
  40. Zou GM, Maitra A. Small molecule inhibitor of the APE1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration. Mol Cancer Ther 2008 Jul;7(7):2012-21.

2004-2005 Annual Report +
  1. Albores-Saavedra J, Wu J, Crook T, Amirkhan RH, Jones L, Hruban RH. Intestinal and oncocytic variants of pancreatic intraepithelial neoplasia. A morphologic and immunohistochemical study. Ann. Diagn. Pathol. 2005 Apr;9:69-76.
  2. Bhattacharya B, Dilworth HP, Iacobuzio-Donahue C, Ricci F, Weber K, Furlong MA, Fisher C, Montgomery E. Nuclear beta-Catenin Expression Distinguishes Deep Fibromatosis From Other Benign and Malignant Fibroblastic and Myofibroblastic Lesions. Am J Surg Pathol. 2005 May;29(5):653-659.
  3. Brosens LA, Iacobuzio-Donahue CA, Keller JJ, Hustinx SR, Carvalho R, Morsink FH, Hylind LM, Offerhaus GJ, Giardiello FM, Goggins M. Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism. Clin Cancer Res. 2005 Jun 1;11(11):4090-6.
  4. Cao D, Maitra A, Saavedra J, Klimstra DS, Adsay NV, Hruban RH. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. Mod Pathol. Jun 18(6):752-61, 2005.
  5. Canto MI, Goggins M, Yeo CJ, Griffin C, Axilbund JE, Brune K, Ali SZ, Jagannath S, Petersen GM, Fishman EK, Piantadosi S, Giardiello FM, Hruban RH. Screening for pancreatic neoplasia in high-risk individuals: An EUS-based neoplasia. Clin Gastroenterol Hepatol. 2(7):606-621, 2004.
  6. Fukushima N, Sato N, Prasad N, Leach SD, Hruban RH, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 2004 Dec 2;23(56):9042-51
  7. Fukushima N, Koopmann J, Sato N, Prasad N, Carvalho R, Leach SD, Hruban RH, Goggins M. Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma. Mod Pathol. 2005 Jun;18(6):779-87.
  8. Hansel DE, Rahman A, House M, Ashfaq R, Berg K, Yeo CJ, Maitra A. Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Clin Cancer Res. 2004 Sep 15;10(18):6152-8.
  9. Hansel DE, Ashfaq R, Rahman A, Wanzer D, Yeo CJ, Wilentz RE, Maitra A. A subset of pancreatic adenocarcinomas demonstrates co-amplification of Topoisomerase II Alpha and HER2/NEU; use of immunolabeling and multi-color FISH for potential patient screening and treatment. Am J Clin Pathol 2005 Jan;123:1-8.
  10. Hansel DE, Dhara S, Huang RC, Ashfaq R, Deasel M, Shimada Y, Bernstein HS, Harmon J, Brock M, Forastiere A, Washington MK, Maitra A, Montgomery E. CDC2/CDK1 Expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Am J Surg Pathol. 2005 Mar;29(3):390-399.
  11. Hansel DE, Maitra A, Lin JW, Goggins M, Argani P, Yeo CJ, Piantadosi S, Leach SD, Biankin AV. Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. J Clin Oncol. 2005 Mar 20;23(9):1811-8.
  12. Hansel DE, Rahman A, Wilentz RE, Shih IeM, McMaster MT, Yeo CJ, Maitra A. HLA-G Upregulation in Pre-Malignant and Malignant Lesions of the Gastrointestinal Tract. Int J Gastrointest Cancer. 2005 Feb;35(1):15-24.
  13. Hariri A, Siegelman SS, Hruban RH. Duodenal diverticulum mimicking a cystic pancreatic neoplasm. Br J Radiol. 2005 Jun;78(930):562-4.
  14. Hruban RH, Takaori K, Klimstra DS, Adsay NV, Albores-Saavedra J, Biankin AV, Biankin SA, Compton C, Fukushima N, Furukawa T, Goggins M, Kato Y, Kloppel G, Longnecker DS, Luttges J, Maitra A, Offerhaus GJ, Shimizu M, Yonezawa S. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004 Aug;28(8):977-87.
  15. Hruban RH, Wilentz RE, Maitra A. Identification and Analysis of Precursors to Invasive Pancreatic Cancer. In Pancreatic Cancer: Methods and Protocols. Su GH ed. Humana Press, Chapter 1, 2004.
  16. Hustinx SR, Cao D, Maitra A, Sato N, Martin ST, Sudhir D, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Kern SE, Goggins M, Mollenhauer J, Pandey A, Hruban RH. Differentially Expressed Genes in Pancreatic Ductal Adenocarcinomas Identified through serial analysis of gene expression. Cancer Biol Ther. 2004 Dec 14;3(12):1254-1261.
  17. Hustinx SR, Fukushima N, Zahurak ML, Riall TS, Maitra A, Brosens L, Cameron JL, Yeo CJ, Offerhaus GJ, Hruban RH, Goggins M. Expression and Prognostic Significance of 14-3-3sigma and ERM Family Protein Expression in Periampullary Neoplasms. Cancer Biol Ther. 2005 May 13;4(5):596-601.
  18. Ji H, Yardley JH. Iron medication-associated gastric mucosal injury. Arch Pathol Lab Med 2004 Jul;128(7):821-822.
  19. Maitra A, Fukushima N, Takaori K, Hruban RH. Precursors to invasive pancreatic cancer. Adv Anat Pathol. 2005 Mar;12(2):81-91.
  20. Martin ST, Matsubayashi H, Rogers CD, Philips J, Couch FJ, Brune K, Yeo CJ, Kern SE, Hruban RH, Goggins M. Increased prevalence of the BRCA2 polymorphic stop codon K3326X among individuals with familial pancreatic cancer.Oncogene. Oncogene. 2005 May 19;24(22):3652-6.
  21. Matsubayashi H, Fujiwara S, Kobayashi Y, Iiri T, Mitra A, Goggins M, Hruban RH, Moriyasu F. A small cell carcinoma of the pancreas with a high level of serum ProGRP. J Clin Gastroenterol. 2004 Oct;38(9):834-5.
  22. Montgomery E, Riddell RH. Spindle cell tumors of the gastrointestinal tract. Pathology Case Reviews 2004 Jul/Aug;9(4):142-146.
  23. Montgomery E. Is there a way for pathologists to decrease interobserver variability in the diagnosis of dysplasia? Arch Pathol Lab Med. 2005 Feb;129(2):174-6.
  24. Riddell RH, Montgomery E. Neoplastic diseases of the lower gastrointestinal tract. Pathology Case Reviews 2004 Jul/Aug;9(4):133-134 [editorial].
  25. Rogers CD, Couch FJ, Brune K, Martin ST, Philips J, Murphy KM, Petersen G, Yeo CJ, Hruban RH, Goggins M. Genetics of the FANCA gene in familial pancreatic cancer. J Med Genet. 2004 Dec;41(12):e126.
  26. Sato N, Maehara N, Goggins M. Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res. 2004 Oct 1;64(19):6950-6.
  27. Sato N, Parker AR, Fukushima N, Miyagi Y, Iacobuzio-Donahue C, Eshleman JR, Goggins M. Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. Oncogene 2005 Jan;24:850-8.
  28. Shi C, Eshleman SH, Jones D, Fukushima N, Hua L, Parker AR, Yeo CJ, Hruban RH, Goggins MG, Eshleman JR. LigAmp for Sensitive Detection of Single Nucleotide Differences. Nature Methods 2004 Nov;1(2):141-147.
  29. Van Heek NT, Maitra A., Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay V, Ashfaq R, Yeo CJ, Cameron JL, Offerhaus JA, Hruban RH, Berg KD, Goggins M. Gene expression profiling identifies markers of ampullary adenocarcinoma. Cancer Biol Ther. 2004 Jul 9;3(7) 651-656.

2003 Annual Report +
  1. Abraham SC, Leach S, Yeo CJ, Cameron JL, Murakata LA, Boitnott JK, Albores-Saavedra J, Hruban RH. Eosinophilic pancreatitis and increased eosinophils in the pancreas. Am J Surg Pathol. 2003; 27:334-42.
  2. Abraham SC, Wilentz RE, Yeo CJ, Sohn TA, Cameron JL, Boitnott JK, Hruban RH. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they all 'chronic pancreatitis'? Am J Surg Pathol. 2003 Jan;27(1):110-20.
  3. Atassi T, Montgomery E. Kaposi's sarcoma. Images in Medicine. NEJM 2003: 349; 2340.
  4. Fukushima N, Sato N, Sahin F, GH, Hruban R, Goggins M. Aberrant methylation of suppressor of cytokine signaling (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer 2003 Jul;89;338-43.
  5. Fukushima N, Walter K, Ueki T, Sato N, Matsubayashi H, Cameron, J. Hruban, R. H, Canto M, Yeo CJ, Goggins M. Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice. Cancer Biology and Therapy 2003 Jan/Feb;2:159;1-159/6.
  6. Hansel DE, Rahman A, Hidalgo M, Thuluvath PJ, Lillemoe KD, Shulick R, Ku JL, Park JG, Miyazaki K, Ashfaq R, Wistuba II, Varma R, Hawthorne L, Geradts J, Argani P, Maitra A. Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol 2003 Jul;163(1):217-29.
  7. Hansel DE, Kern SE, Hruban RH. Molecular pathogenesis of pancreatic cancer. Annu Rev Genomics Hum Genet 2003 Sep;4:237-256.
  8. Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ, Maitra A. Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res. 2003 Nov 1;63(21):7032-7.
  9. Hoofring A, Boitnott J, Torbenson M. Three-Dimensional Reconstruction of Hepatic Bridging Fibrosis. J Hepatol. 2003 Nov;39(5):738-41.
  10. Iacobuzio-Donahue CA, Maitra A, Olsen M, Lowe AW, van Heek T, Rosty C, Parker A, Ashfaq R, Jaffee E, Ryu B, Jones J, Eshleman JR, Yeo, CJ, Cameron, JL, Kern SE, Hruban, R. H, Brown PO, Goggins M. Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol 2003;162:1151-62.
  11. Iacobuzio-Donahue CA, Hruban RH. Gene expression in neoplasms of the pancreas: applications to diagnostic pathology. Adv Anat Pathol 2003 May;10(3):125-134.
  12. Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SC, Goggins M, Hruban RH. Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res. 2003 Dec 15;63(24):8614-8622.
  13. Iacobuzio-Donahue CA and Maitra A, et al Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol 2003 Apr;162(4):1151-62.
  14. Koteish A, Kannangai R, Abraham S, Torbenson M. Colonic Spirochetosis in Children and Adults. Am J Clin Pathol. 2003 Dec;120(6):828-32.
  15. Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron JL, Yeo CJ, Hruban RH. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray.Mod Pathol. 2003 Sep;16(9):902-12.
  16. Matsubayashi H, Sato N, Fukushima N, Yeo CJ, Walter KM, Brune K, Sahin F, Hruban RH, Goggins M. Methylation of Cyclin D2 is Frequently Observed in Pancreatic Cancer but is also an Age-related Phenomenon in Gastrointestinal Tissues. Clin Cancer Res 2003;9:1446-52.
  17. Matsubayashi H, Fukushima N, Sato N, Brune K, Canto M, Yeo CJ, Hruban RH, Kern SE, Goggins M. Polymorphisms of SPINK1 N34S and CFTR in Patients with Sporadic and Familial Pancreatic Cancer. Cancer Biol Ther. 2003 Nov/Dec;2(6):e1-e4.
  18. Montgomery E, Fisher C. Paratesticular liposarcoma: a clinicopathologic study. Am J Surg Pathol 2003 Jan;27(1):40-7.
  19. Parker AR and Eshleman JR. Human MutY: Gene structure, protein functions and interactions, and role in carcinogenesis. Cellular and Molecular Life Sciences 2003 Oct;60(10):2064-83.
  20. Parker AR, O'Meally RN, Sahin F, Su GH, Racke FK, Nelson WG, DeWeese TL, Eshleman JR. Defective Human MutY Phosphorylation Exists in Colorectal Cancer Cell Lines With Wild-Type MutY Alleles. J Biol Chem 2003 Nov;278(48):47937-45.
  21. Petersen GM, Hruban RH. Familial pancreatic cancer: Where are we in 2003? J Natl Cancer Inst. 2003 Feb 5;95(3):180-1.
  22. Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, Cameron JL, Yeo CJ, Hruban RH, Goggins M. p16 Inactivation in Pancreatic Intraepithelial Neoplasias (PanINs) Arising in Patients with Chronic Pancreatitis. Am J Surg Pathol. 2003 Dec; 27(12):1495-501.
  23. Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E, Goggins M, Hruban RH, Su GH. Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol. 2003 Jul;16(7):686-91.
  24. Sato N, Fukushima N, Anirban Maitra, Matsubayashi M, Yeo CJ, Cameron JL, Hruban R, Goggins M. Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res 2003 Jul;63:3735-42.
  25. Sato N, Maitra A, Fukushima N, Matsubayashi M, Van Heek NT, Iacobuzio-Donahue C, Rosty C, Goggins M. Frequent Hypomethylation of Multiple Genes Overexpressed in Pancreatic Ductal Adenocarcinoma. Cancer Res 2003 Jul;63:4158-66.
  26. Sato N, Fukushima N, Maehara N, Matsubayashi H, Koopmann J, Su GH, Hruban RH, Goggins M. SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene 2003 Aug;22(32):5021-5030.
  27. Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E, Goggins M, Hruban RH, Su GH. Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol. 2003 Jul;16(7):686-91.
  28. Sato N, Maehara N, Su GH, Goggins M. Up-regulation of Matrix Metalloproteinases and Increased Invasiveness in Pancreatic Cancer Cells by the Demethylating Agent 5-Aza-2'-deoxycytidine. J Natl Cancer Institute 2003 Feb:95:327-330.
  29. Torbenson M, Wang J, Abraham S, Maitra A, Boitnott J. Bile Ducts and Ductules are Positive for CD6 (N-CAM) in Most Cases of Extrahepatic biliary atresia. Am J Surg Pathol. 2003 Nov;27(11):1454-7.