Le Cancer Metabolism Research Laboratory


Publications

Corresponding author: +
  1. Metabolomics-Based Identification of Metabolic Dysfunction in Frailty.
    J Gerontol A Biol Sci Med Sci. 2021 October. Accepted.
  2. Serum and urinary metabolites discriminate disease activity in ANCA-associated glomerulonephritis. J Nephrol. 2021 Jun 28. PMID: 34181196
  3. The Limitless Applications of Single-Cell Metabolomics. Current Opinion in Biotechnology. 2021 Jul 30;71:115-122. PMID: 34339935
  4. Glucose Metabolism in Cancer: the Warburg effect and Beyond. Adv Exp Med Biol. 2021. PMID: 34014531
  5. Glutamine Metabolism in Cancer. Adv Exp Med Biol. 2021. PMID: 34014532
  6. The Heterogeneity of Lipid Metabolism in Cancer. Adv Exp Med Biol. 2021. PMID: 34014533
  7. The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions. Adv Exp Med Biol. 2021. PMID: 34014534
  8. The Intricate Metabolism of Pancreatic Cancers. Adv Exp Med Biol. 2021. PMID: 34014535
  9. The Heterogeneity of Breast Cancer Metabolism. Adv Exp Med Biol. 2021. PMID: 34014536
  10. Non-Hodgkin's Lymphoma Metabolism. Adv Exp Med Biol. 2018;1063:95-106. PMID: 29946778
  11. The Heterogeneity Metabolism of Renal Cell Carcinomas. Adv Exp Med Biol. 2021. PMID: 34014538
  12. The Heterogeneity Metabolism of Liver Cancer. Adv Exp Med Biol. 2021. PMID: 34014539
  13. Different Tumor Microenvironments Lead to Different Metabolic Phenotypes. Adv Exp Med Biol. 2021. PMID: 34014540
  14. The Intratumoral Heterogeneity of Cancer Metabolism. Adv Exp Med Biol. 2021. PMID: 34014541
  15. Cancer Stem Cells Metabolism. Adv Exp Med Biol. 2021. PMID: 34014546
  16. Metabolism of Immune Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2021. PMID: 34014546
  17. Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells. Adv Exp Med Biol. 2021. PMID: 34014544
  18. Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts. Adv Exp Med Biol. 2021. PMID: 34014545
  19. Diabetes and Cancer: the Epidemiological and Metabolic Associations. Adv Exp Med Biol. 2021. PMID: 34014546
  20. Bridging the Metabolic Parallels between Neurological Diseases and Cancer. Adv Exp Med Biol. 2021. PMID: 34014547
  21. Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy. Adv Exp Med Biol. 2021. PMID: 34014548
  22. Uncovering Metabolic Reservoir Cycles in MYC-Transformed Lymphoma B cells Using Stable Isotope Resolved Metabolomics. Anal Biochem. 2021 Apr 21;114206. PMID: 33894159
  23. Inhibition of Glutaminolysis in Combination with Other Therapies to Improve Cancer Treatment. Curr Opin Chem Biol. 2021 Mar 12;62:64-8. PMID: 33721588
  24. Therapies Targeting Glutamine Addiction in Cancer. Encyclopedia of Biochemistry 3rd Edition. 2021. https://doi.org/10.1016/B978-0-12-819460-7.00079-7
  25. The Metabolic Interplay between Cancer and Other Diseases. Trends in Cancer. 2019 Dec;5(12):809-821. PMID: 31813458
  26. Application of metabolomics technologies toward cancer prognosis and therapy. International Review of Cell and Molecular Biology. Int Rev Cell Mol Biol. 2019; 347:191-223. PMID: 31451214
  27. Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer. Proteomics. 2019 Jun 24:e1800451. PMID: 31231915
  28. Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy. Molecular & Cellular Oncology. PMID: 31528698
  29. Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. Cell Rep. 2019 Apr 9;27(2):491-501. PMID: 30970252
  30. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Aug 24. PMID: 27559084
  31. Glucose-independent Glutamine-driven TCA Cycle in Cancer Cells. Glutamine in Health and Disease. Glutamine in Clinical Nutrition, Nutrition and Health DOI 10.1007/978-1-4939-1932-1_6
  32. Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia cell cycle dual reporter. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34): 12486-12491. PMID: 25114222
  33. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012 Jan 4;15(1):110-21. PMID: 22225880

First author: +
  1. Designing a broad-spectrum integrative approach for cancer prevention and treatment (Equal contribution; authors listed alphabetically). Semin Cancer Biol. 2015 Dec;35 Suppl:S276-304. PMID: 26590477.
  2. Dysregulated Metabolism Contributes to Oncogenesis (Equal contribution; authors listed alphabetically). Semin Cancer Biol. 2015 Dec;35 Suppl:S129-50. PMID: 26454069.
  3. Studying Myc's role in metabolism regulation. Methods Mol Biol. 2013;1012:213-9. PMID: 24006067.
  4. Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors (Co-first author). Cancer Res. 2013 Jul 15;73(14):4190-5. PMID: 23722553.
  5. Conceptual framework for cutting the pancreatic cancer fuel supply. Clin Cancer Res. 2012 Aug 15;18(16):4285-90. PMID: 22896695.
  6. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA. 2010 Feb 2; 107(5):2037-42. PMID: 20133848.
  7. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med. 2009 Sep 1;180(5):396-406. PMID: 19520907.
  8. Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury. J Appl Physiol (1985). 2008 Oct;105(4):1282-90. PMID: 18669934.

Co-author: +
  1. Valsartan Nano-Filaments Alter Mitochondrial Energetics and Promote Faster Healing in Diabetic Rat Wounds. Wound Repair and Regeneration. 2021 Sep. Accepted.
  2. Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by Cardiolipin-interacting small molecules. J Biol Chem. 2021 Jul 24:101005. PMID: 34314685
  3. Mitochondrial copper depletion suppresses triple-negative breast cancer in mice. Nat Biotechnol. 2020 Oct 19. PMID: 33077961
  4. Inhibiting MYC-regulated Glutaminase Metabolic Axis is an Effective Synthetic Lethal Approach for Treating Chemoresistant Cancers. Cancer Res. 2020 Aug 28:canres.3971.2019. PMID: 32859605
  5. Kynurenines Link Chronic Inflammation to Functional Decline & Physical Frailty. JCI Insight. 2020 Aug 20;5(16):136091. PMID: 32814718
  6. Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker. Bioorganic & Medicinal Chemistry Volume 28, Issue 20, 15 October 2020, 115698
  7. Targeted Deletion of interleukin-6 in a Mouse Model of Chronic Inflammation Demonstrates Opposing Roles in Aging: Benefit and Harm. J Gerontol A Biol Sci Med Sci. 2020 Jun 26. PMID: 32585682
  8. Regulation of Mitochondrial Fragmentation in Microvascular Endothelial Cells Isolated from the Su5416/Hypoxia model of Pulmonary Arterial Hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 28. PMID: 31461316.
  9. Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation. Free Radic Biol Med. 2018 Apr 9. pii: S0891-5849(18)30174-6. PMID: 29649567.
  10. Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment. Oncogene. 2017 Sep 4. PMID: 28869602.
  11. Discovery of 6-Diazo-5-oxo-L-norleucine (DON) prodrugs with enhanced CSF delivery in monkeys a potential treatment for glioblastoma. J Med Chem. 2016 Aug 25. PMID: 27560860.
  12. Allosteric Glutaminase Inhibitors Based on a 1, 4-Di (5-amino-1, 3, 4-thiadiazol-2-yl) butane Scaffold. ACS Med Chem Lett. 2016 Mar 13;7(5):520-4. PMID: 27200176
  13. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest. 2015 Jun 1;125(6):2293-306. PMID: 25915584.
  14. Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function. Cancer Res. 2015 Aug 15;75(16):3355-64. PMID: 26113084
  15. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife. 2014 Jul 9;3. PMID: 25009227.
  16. Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung. PLoS Genet. 2013;9(2):e1003228. PMID: 23459311.
  17. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci USA. 2012 Jun 5;109(23):8983-8. PMID: 22615405.
  18. Metabolic and electrochemical mechanisms of dimeric naphthoquinones cytotoxicity in breast cancer cells. Bioorg Med Chem. 2011 Dec 1;19(23):7057-62. PMID: 22036210.
  19. Therapeutic targeting of cancer cell metabolism. J Mol Med (Berl). 2011 Mar;89(3):205-12. PMID: 21301795.
  20. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci USA. 2010 Feb 23;107(8):3534-9. PMID: 20133585.
  21. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009 Nov 1;15(21):6479-83. PMID: 19861459.
  22. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. PLoS One. 2009;4(2):e4600. PMID: 19240800.